Case report: A case of primary cardiac malignant mesothelioma

Primary cardiac malignant tumors are extremely rare, making up about 10% of all primary cardiac tumors. Most of these tumors are primary sarcomas, with primary mesothelioma being even less common. This report details a 53-year-old male patient diagnosed with primary cardiac malignant mesothelioma. The patient had symptoms of chest pain and difficulty breathing. A CT scan showed an enlarged heart, fluid around the heart, and irregular thickening of the pericardium. Diagnosis was confirmed through a surgical biopsy, which showed the presence of malignant mesothelioma. After the procedure, the patient received appropriate cardiac support. Although stable at discharge, the patient unfortunately died three months later due to severe wheezing. There may be a potential link between exposure to radioactive iodine treatment and this outcome. This case highlights the diagnostic and treatment challenges of primary cardiac malignant tumors and reminds physicians to consider this rare disease when evaluating patients with similar symptoms

Ultrasonic Extraction of Tropane Alkaloids from Radix physochlainae Using as Extractant an Ionic Liquid with Similar Structure

In this research, tropane alkaloids in Radix physochlainae were extracted by tropine-type ionic liquid (IL) aqueous solutions under ultrasound assistance, and N-propyltropine hexafluorophosphate ([C3Tr][PF6]) was found to be the most ideal IL in this extraction mode after comprehensive screening. When 0.03 mol/L [C3Tr][PF6] aqueous solution was chosen as the extraction solvent, the solid-liquid ratio of raw material powders and ionic liquid aqueous solution was 1:20 (g/mL), ultrasonic power was 90 W and extraction time was 30 min, the extraction efficiency of tropane alkaloids has reached 121.3%. Compared with common heating extraction, it can further shorten the extraction time, improve extraction efficiency and decrease IL consumption. Furthermore, extraction mechanism together with potential toxicity of IL have been explored and discussed

Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder mainly in middle-elderly population, which represents diverse nonmotor symptoms (NMS) besides such well-documented motor symptoms as bradykinesia, resting tremor, rigidity, and postural instability. With the advancement of aging trend worldwide, the global prevalence of PD is mounting up year after year. Nowadays, accumulating lines of studies have given a comprehensive and thorough coverage of motor symptoms in PD. Yet much less attention as compared has been paid to the nonmotor symptoms of PD, such as cognition deficits. Of note, a patient with PD who suffers from cognitive impairment may harbour a statistically significantly higher risk of progressing toward dementia, which negatively affects their life expectancy and daily functioning and overall lowers the global quality of life. Furthermore, it is a widely held view that cognitive dysfunction does not just occur in the late stage of PD. On the basis of numerous studies, mild cognitive impairment (MCI) is a harbinger of dementia in PD, which is observed as an intermediate state with considerable variability; some patients remain stable and some even revert to normal cognition. Considered that the timing, profile, and rate of cognitive impairment vary greatly among PD individuals, it is extremely urgent for researchers and clinicians alike to identify and predict future cognitive decline in this population. Simultaneously, early screening and canonical management of PD with cognitive deficits are very imperative to postpone the disease progression and improve the prognosis of patients. In our review, we focus on a description of cognitive decline in PD, expound emphatically the pathological mechanisms underlying cognition deficits in PD, then give a comprehensive overview of specific therapeutic strategies, and finally dissect what fresh insights may bring new exciting prospect for the subfield

Mathematical Physics Modelling and Prediction of Oil Spill Trajectory for a Catenary Anchor Leg Mooring (CALM) System

The catenary anchor leg mooring (CALM) system usually moored a heavy oil tanker; due to its complex working mechanism and special working environment, oil spill accidents are easy to happen. Once the oil spill accident happens, it not only causes huge economic loss, but also kills the marine ecological environment. Oil spill trajectory model considers almost all weathering processes including evaporation, emulsification, dispersion, dissolution, photooxidation, sedimentation, and biodegradation. Model simulations indicated that both tidal currents and wind drag force have significant effect in oil spill movement. The dominant wind in the area is South-westerly wind during the summer monsoon and North-easterly wind during the winter monsoon, but South-westerly wind is far stronger and last longer than the North-easterly wind. As a result, oil spill trajectory is most likely towards offshore to North-east during the summer period (April to September). During the winter period (November–January), oil spill would move towards shore under North-westerly winds. Once oil reaches shore, it would stay at shore permanently and eventually sink to seabed or beach in the simulation. Although the model does not consider longshore drift by waves, oil movement along shore by waves would be a slow process. Therefore, the impact of oil spill during the winter monsoon would be limited to local area around Ras Markaz

Design of embedded chain inverse catenary of deepwater FPSO mooring suction pile

FPSO is the main development model of deepwater oil field in South China Sea, and it has high requirements for the reliability of single-point mooring system. Therefore, the design investigation of inverse catenary of deepwater FPSO mooring suction pile was conducted. Meanwhile, a complete mathematical model for inverse catenary of suction pile was established based on the characteristics and mechanics of seabed soil, and a calculation method for the slack of inverse catenary was proposed. Besides, taking a deepwater FPSO project in the South China Sea as the research object, analysis on mooring under the designed survival condition (1 000-yr-RP) and the designed extreme condition (100-yr-RP) was performed based on the mooring load conditions required by classification societies to obtain the seabed mooring load. As shown by the evaluation results on design of embedded chain inverse catenary and its slack, the tension range of the embedded chain inverse catenary for suction pile of this FPSO mooring is 10 254 kN to14 075 kN, the load angle range is 16.2° to 30.1°, and the horizontal projection distance of the embedded chain is 47.33 m to 80.30 m. Further, the results based on different rules are close to each other for mutual verification. The final results of analysis and design could provide experience for similar FPSO projects

Data from: Structural modification of isomorphous SO42−-doped K2FeO4 for remediating the stability and enhancing the discharge of super-iron battery

In the paper, the isomorphous SO42- doped K2FeO4, aimed at the remediation of the discharge and stability of the super-iron battery, was first synthesized for doping and reforming the K2FeO4 crystalline structure via a facile coprecipitation and mechanochemistry. Afterward, the compared cathodes were assembled by the undoped and doped K2FeO4 for an evaluation of the discharge and stability in the AAA super-iron battery system. The results show that the small amounts of K2SO4 were doped into the K2FeO4 in the calculated form of K2Fe1-xSxO4 by the isomorphous substitution. The doped K2FeO4 cathodes/batteries exhibited an excellent discharge with a normal discharge profile. The cathodes doped by two techniques had significantly enhanced the discharge capacity of the super-iron battery with an increase of 10-30% compared to the undoped K2FeO4. Moreover, the stability of the K2FeO4 cathodes was obviously remediated by the isomorphous SO42- doping. The shelf time of the doped K2FeO4 cathodes was prolonged by an increase of about 10% in comparison of the undoped K2FeO4 cathode. The desirable enhancements could be attributed to doping and reforming the similar building block and isomorphous SO42- into the FeO42- tetrahedral and crystalline in the form of the isomorphous substitution and filling vacancies

Data for the figures

Data for the figure