Thyroid disorders in pregnancy: prevalence and its fetomaternal outcome in a tertiary hospital of Delhi, India

Background: This study was conducted to determine the feto maternal outcome in pregnant women with thyroid disorders. The prevalence of thyroid disorders in present study was 15.75%.Methods: This was a prospective observational study carried out in all pregnant women irrespective of their parity, who attended ANC clinic in department of obstetrics and gynaecology in a tertiary care hospital over a period of 2 years. After registering, the patients were followed up with routine antenatal visits up to delivery and records were reviewed for development of abortion, PIH, preterm delivery, GDM, anemia, placental abruption, still birth, anomalies, fetal distress, meconium stained liquor, low birth weight and neonatal outcome by neonate Apgar score and TSH value.Results: Mean age group in our study was 27.61±3.14. Family history was present in 8% of study group versus 0% in control group which was statistically significant (p=0.028). Eighteen percent of preeclampsia was diagnosed in study group as compared to 4% in control group which was statistically significant (p-value= 0.005). Fourteen percent patients had preterm labour in study group as compared to 6.7% in control group which was statistically significant (p value= 0.047). Increased neonatal TSH was found in study group (61.3%) as compared to control group (32%), this difference was statistically significant (p-value <0.001). There was increased importance of measuring TSH in first trimester as it was statistically significant in study group (p-value <0.001).Conclusions: All pregnant women should be screened for hypothyroidism as early as possible or before conception to prevent any fetomaternal complications

The Role and Impact of ATMs in reducing Regional Disparities to Enhance Competitive Edge for the Indian Economy

Every nation runs its economic chariot through the guidance of the banking sector. The policy makers work on the twin objectives of removing regional imbalances across the length and breadth of the country and to reach out to the underprivileged masses of the society in our country. To serve objectives with such lofty ideals, not only does profit making take a back seat, it also calls in for investment in infrastructure to enhance competitive edge to the entire sector.&nbsp; The power of nationalization was seen as it emerged to shift focus from ―Class Banking‖ to ―Mass banking‖, from ―Profit Banking‖ to ―Social Banking‖ and from ―Elite Banking‖ to ―Every body‘s Banking.&nbsp; Automated Teller Machines (ATM), Telephonic Customer Service (TCS), online banking and mobile banking are the most prominent ones amongst banking technological advances. Yet, has it really touched the heart and soul of the country? The measurable progress with its impressive numbers, guided by policy making at the centre, has churned out progress year after year and managed to hide a growing hole called the disparity in banking services between the urban and rural masses

Using the Advantages of NOSQL: A Case Study on MongoDB

With such a big volume of data growing tremendously every day, the storage of information, support and maintenance have become difficult. A further level of difficulty is added by the variety of data being captured. The data stored and updated on daily bases is in the form of logs, audio, video, sensor data and so on, which is not easy to be stored and queried using relational database. The paper gives the overview of NOSQL databases which provide more scalability and efficiency in storage and access of the data. A case study on MongoDB is done as to show the representational format and querying process of NOSQL database. The concepts of MongoDB are compared to the relational databases

Degradation of acidic Orange G dye using UV-H2O2 in batch photoreactor

Degradation of Orange G dye has been investigated using UV irradiation with hydrogen peroxide (H2O2) in a batch photoreactor. UV irradiation and H2O2 resulted in significant photodegradation of the dye although the effect individual reaction was very little. The degradation was studied to elucidate the effect of various process parameters such as pH, concentration of dye, dose of H2O2, TiO2 and light intensity/light source with reflecting or non reflecting surface of photoreactor. Results showed the efficient degradation of Orange G for typical process conditions.Keywords: Orange G, UV/H2O2, photoreactor, degradation, process parameters

Osteosarcoma of jaw, common entity at an uncommon site: a rare case report

Osteosarcoma is the most common primary malignant bone tumor. Jaw is an uncommon site. The etiopathogenesis is still unknown. We present a case of 47-year-old female who underwent left partial maxillectomy as the lesion increased in size over one month after removal of a tooth. Prior to the surgery, computed tomography (CT) scan was suggestive of left maxillary sinus carcinoma and biopsy report was suggestive of spindle cell lesion. Partial maxillectomy specimen received in which size of the tumor was 5.5×5.5×4 cm with a pearly-white, solid, homogenous cut surface with gritty sensation on cutting. On histopathology it turned out to be osteosarcoma of the jaw. Mouse double minute 2 homolog (MDM2) and special AT-rich sequence-binding protein 2 (SATB2) was done to confirm the diagnosis of osteosarcoma. The patient was given chemotherapy after the confirmation and at present the patient is doing well

Targeting NSP-13 protein of SARS CoV-2 with selected natural compounds: An in-silico approach

SARS-CoV-2 swiftly spread in Wuhan, China, leading to a pandemic crisis worldwide. Genome sequence analysis of this virus revealed a close analogy with its closely related strains, SARS-COV and MERS-COV. In the case of SARS-CoV-2, Nonstructural protein 13 (NSP13), also known as helicase, has been identified as a target for reducing the severity of infection due to its high sequence conservation and essential role in viral replication. NSP13 helicase structure in SARS-CoV-2 differs only by one amino acid from the SARS-CoV helicase structure. Targeting NSP13 with natural compounds holds significant potential for developing safe and effective antiviral therapies utilizing advanced computational approaches. The properties of 8 different natural compounds, i.e. Imidazole, Pyrrole, Tropolone, Benzotriazole, Imidazodiazepine, Phenothiazine, Acridone and Bananin were screened by applying Lipinski’s rule of five, ADME (absorption, distribution, metabolism, and excretion) properties, and Radar plots to discover their drug efficacy at a target site, safety, and absorption. Docking studies confirmed Bananin with a binding affinity of -7 kcal/mol as a potential inhibitor of NSP13 of SARS-CoV-2 with better pharmacokinetics, drug likeliness, and oral bioavailability. Based on the in silico study, it is suggested that Bananin shows promising effects against NSP13 protein, forming a maximum number of hydrogen bonds exhibiting higher binding affinity. This stronger affinity indicates a stronger interaction between the compound and its target, potentially leading to enhanced biological activity and therapeutic efficacy. This novel study has unlocked the door for a prospective SARS-CoV-2 inhibition strategy and developing antiviral interventions targeting NSP13 based on molecular docking.

Precision Agriculture and Financial Management: A Profitable Synergy

This comprehensive study explores the dynamic interplay between Precision Agriculture and Financial Management, shedding light on their pivotal roles in the contemporary agricultural landscape. Precision Agriculture, underpinned by cutting-edge technologies and tools, delivers a host of compelling benefits, including amplified crop yields, judicious resource allocation, and robust environmental stewardship. Financial Management in agriculture anchors its foundations on two critical pillars: the pursuit of financial sustainability and the proficient utilization of financial metrics and analysis. These multifaceted domains are instrumental in ensuring the enduring viability of farming operations, underscoring their intrinsic value in agricultural practices. The symphony between Precision Agriculture and Financial Management significantly amplifies the financial dynamics of farming. Their convergence cultivates an environment that nurtures profitability, upholds cost-efficiency, and champions ecological responsibility. This confluence is poised to address the burgeoning global food demand, charting a course toward optimal resource utilization, sustainable agricultural practices, and the safeguarding of the environment. This chapterembarks on a comprehensive exploration of this synergistic relationship, elucidating the profound impact of data-driven decision-making, advanced technology integration, and meticulous resource management on the farm's bottom line. The outcome of this partnership holds the potential to redefine the agricultural landscape, ensuring not only the prosperity of farming operations but also the responsible stewardship of the earth's resources

Cerebral pilocytic astrocytoma with spontaneous intratumoral haemorrhage in the elderly - a rare entity: A case report and review of the literature

Pilocytic astrocytomas (PA) are histologically are low-grade tumours, commonly found in the paediatric and young adult population. Although cases of adult and elderly pilocytic astrocytomas are described in the literature, they are quite uncommon. The rate of PAs with spontaneous bleeding is very less, with a high occurrence in children than in adults, moreover, that is in cerebellar PAs. Cerebral PAs with intratumoral haemorrhage in the older age group is extremely rare. We present a case of a 60-year female presenting with acute neurological compromise resulting from an acutely haemorrhagic Left temporal pilocytic astrocytoma. She was managed surgically with evacuation of tumoral haemorrhages, as well as resection of the tumour. Postoperatively the patient made a remarkable recovery