381 research outputs found
Key Issues in the Modes of Action and Effects of Trichloroethylene Metabolites for Liver and Kidney Tumorigenesis
Trichloroethylene (TCE) exposure has been associated with increased risk of liver and kidney cancer in both laboratory animal and epidemiologic studies. The U.S. Environmental Protection Agency 2001 draft TCE risk assessment concluded that it is difficult to determine which TCE metabolites may be responsible for these effects, the key events involved in their modes of action (MOAs), and the relevance of these MOAs to humans. In this article, which is part of a mini-monograph on key issues in the health risk assessment of TCE, we present a review of recently published scientific literature examining the effects of TCE metabolites in the context of the preceding questions. Studies of the TCE metabolites dichloroacetic acid (DCA), trichloroacetic acid (TCA), and chloral hydrate suggest that both DCA and TCA are involved in TCE-induced liver tumorigenesis and that many DCA effects are consistent with conditions that increase the risk of liver cancer in humans. Studies of S-(1,2-dichlorovinyl)-l-cysteine have revealed a number of different possible cell signaling effects that may be related to kidney tumorigenesis at lower concentrations than those leading to cytotoxicity. Recent studies of trichloroethanol exploring an alternative hypothesis for kidney tumorigenesis have failed to establish the formation of formate as a key event for TCE-induced kidney tumors. Overall, although MOAs and key events for TCE-induced liver and kidney tumors have yet to be definitively established, these results support the likelihood that toxicity is due to multiple metabolites through several MOAs, none of which appear to be irrelevant to humans
Creating Non-Maxwellian Velocity Distributions in Ultracold Plasmas
We present techniques to perturb, measure and model the ion velocity
distribution in an ultracold neutral plasma produced by photoionization of
strontium atoms. By optical pumping with circularly polarized light we promote
ions with certain velocities to a different spin ground state, and probe the
resulting perturbed velocity distribution through laser-induced fluorescence
spectroscopy. We discuss various approaches to extract the velocity
distribution from our measured spectra, and assess their quality through
comparisons with molecular dynamic simulationsComment: 13 pages, 8 figure
Velocity Relaxation in a Strongly Coupled Plasma
Collisional relaxation of Coulomb systems is studied in the strongly coupled
regime. We use an optical pump-probe approach to manipulate and monitor the
dynamics of ions in an ultracold neutral plasma, which allows direct
measurement of relaxation rates in a regime where common Landau-Spitzer theory
breaks down. Numerical simulations confirm the experimental results and display
non-Markovian dynamics at early times.Comment: 5 pages, 5 figure
Classical and quantum anisotropic Heisenberg antiferromagnets
We study classical and quantum Heisenberg antiferromagnets with exchange
anisotropy of XXZ-type and crystal field single-ion terms of quadratic and
cubic form in a field. The magnets display a variety of phases, including the
spin-flop (or, in the quantum case, spin-liquid) and biconical (corresponding,
in the quantum lattice gas description, to supersolid) phases. Applying
ground-state considerations, Monte Carlo and density matrix renormalization
group methods, the impact of quantum effects and lattice dimension is analysed.
Interesting critical and multicritical behaviour may occur at quantum and
thermal phase transitions.Comment: 13 pages, 14 figures, conferenc
Flipper-bands on penguins: what is the cost of a life-long commitment?
The individual marking of flying and flightless birds has a long history in ornithology. It is
the only technique which is cheap, simple and effective, yielding results on bird migration, age-specific annual survival and recruitment. Consequently, hundreds of thousands of birds are annually ringed worldwide. Unfortunately, researchers all too often tend to neglect problems associated with rings and tags. In Antarctic penguins, flipper bands have been used extensively by a variety of nations, and banding is an integral part of the Council for the Conservation of Antarctic Marine Living Resources' (CCAMLR) monitoring programme (Standard method A4). This programme suggests that mortality in penguins wearing bands can be attributed to either (a) prey species availability, (b) predation, (c) weather conditions or (d) other. In this paper, we have attempted to quantify energetic costs associated
with wearing a flipper band. For that purpose, freshly caught Adelie penguins (n = 7) were introduced, in Antarctica, into a 21 m long still-water tunnel, where their behaviour and energy consumption were determined via observation and gas respirometry. Birds were either immediately marked with a flipper band and tested in the tunnel for ca 2 h, and then taken out and tested again after removal of the band, or vice-versa. Flipper bands significantly (ANOVA, p = 0.006) increased the power input of Adelie penguins during swimming by 24 % over the speed range of 1.4 to 2.2 m S-', from 17 W
kg-' to 21.1 W kg-' (n = 115 and 157 measurements, respectively). The implications of banding on foraging performance and sunival of penguins are discussed. Implantable passive transponders could help overcome such problems
Microheterogeneity of cytosolic and membrane-bound hexokinase II in Morris hepatoma 3924A
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