Percepcija vršnjačkog nasilja nad djecom s teškoćama u realnom i virtualnom svijetu

Cilj je ovog rada produbljivanje spoznaja o fenomenu nasilja nad djecom s teškoćama u realnom i virtualnom svijetu. U istraživanju su sudjelovala djeca i mladi s različitim teškoćama (N=20) i njihovi roditelji (N=40). Podatci su prikupljeni u fokus grupama s djecom i mladima te polustrukturiranim intervjuima s roditeljima. Prema iskazima sudionika djeca s teškoćama izložena su verbalnom (uvrede i ponižavanja na temelju njihove teškoće), relacijskom (odbacivanje, izoliranje) i fizičkom nasilju (povlačenje, guranje, izbacivanja iz kolica), kao i seksualnom uznemiravanju. Isto tako doživljavaju i elektroničko nasilje. Utvrđeno je da su dominantni osjećaji žrtava: tuga, ljutnja, strah, bespomoćnost. Svi sudionici smatraju da je vršnjačko nasilje za djecu s teškoćama bolno iskustvo i ozbiljan problem, pa traže primjerenu zaštitu i kvalitetnije preventivne aktivnosti

Trefoil Factor 3 Deficiency Affects Liver Lipid Metabolism

Background/Aims: Tff3 protein plays a well recognized role in the protection of gastrointestinal mucosa. The role of Tff3 in the metabolism is a new aspect of its function. Tff3 is one of the most affected liver genes in early diabetes and fatty liver rodent models. The aim of this study was to investigate the effect of Tff3 deficiency on lipid and carbohydrate metabolism and on markers of oxidative stress that accompanies metabolic deregulation. Methods: Specific markers of health status were determined in sera of Tff3 deficient mice, including glucose level, functional glucose and insulin tolerance. Composition of fatty acids (FAs) was determined in liver and blood serum by using gas chromatography. Oxidative stress parameters were determined: lipid peroxidation level via determination of lipid hydroperoxide and thiobarbituric acid reactive substances (TBARS), antioxidative capacity (FRAP) and specific antioxidative enzyme activity. The expression of several genes and proteins related to the metabolism of lipids, carbohydrates and oxidative stress (CAT, GPx1, SOD2, PPARα, PPARγ, PPARδ, HNF4α and SIRT1) was determined. Results: Tff3 deficient mice showed better glucose utilization in the glucose and insulin test. Liver lipid metabolism is affected and increased formation of small lipid vesicles is noticed. Formation of lipid droplets is not accompanied by increased liver oxidative stress, although expression/activity of monitored enzymes is deregulated when compared with wild type mice. Tff3 deficient mice exhibit reduced expression of metabolism relevant SIRT1 and PPARγ genes. Conclusion: Tff3 deficiency affects the profile and accumulation of FAs in the liver, with no obvious oxidative stress increase, although expression/activity of monitored enzymes is changed as well as the level of SIRT1 and PPARγ protein. Considering the strong downregulation of liver Tff3 in diabetic/obese mice, presence in circulation and regulation by food/insulin, Tff3 is an interesting novel candidate in metabolism relevant conditions

Design and Synthesis of New Macrocyclic Cyclophanes Using 1,3-Dioxane Units as Bridges: A Molecular “Rocking Chair”

International audienc

Electro-reduction of diazonium salts on gold: why do we observe multi-peaks ?

International audienceMulti-peaks have been observed when reducing diazonium salts by cyclic voltammetry (CV). In order to explain that behavior, we studied the electrochemical properties of a fluorinated diazonium salt that exhibits a strongly passivating behavior on various micro-crystalline gold electrodes. We propose here that each sub-peak observed in CV corresponds to the reduction of the compound on a distinct crystallographic sit

Fluorinated functionnalized EDOT-based conducting films

International audienceThree ethylenedioxithiophene (EDOT) derivatives bearing either perfluoro- or ether perfluoro-alkyl chains were synthesized with the objective to prepare films with dry and chemically immobilized lubrication properties. The corresponding fluorinated PEDOT films were deposited on platinum surface by electropolymerization. Cyclic voltammetry (CV) and electrochemical quartz crystal microbalance (EQCM) analyses (both quartz resonant frequency and resonant admittance) of the growing steps are described. The electroactive behavior of the films versus their doping level was followed by electrochemical impedance spectroscopy (EIS) through equivalent circuit fitting procedure and compared to their CV responses. Hysteresis in fit parameters corresponding to capacity and film resistance between the forward and the backward scans are observed and discussed. Control of the chemical structures and charge effects on PEDOT chains are followed by an XPS analysis. From these analyses, it appears that the fluorinated side-arm does not alter both the growing and the electrical properties of the films in respect to the pristine PEDOT taken as referenc

Assessment of Limestone Waste Addition for Fired Clay Bricks

Our aim was to investigate the feasibility of using limestone waste resulting from stone processing for the manufacturing of fired clay bricks. Waste materials were considered as a partial replacement for clays to reduce the exploitation of natural resources and as a response to the climate neutrality commitments. The samples were prepared to have a waste content of up to 15% and were fired at a temperature of 900 °C. The chemical and mineralogical composition and the physical analysis of raw materials were investigated by using SEM–EDS and XRD diffraction. The result showed an increase in CaO in the clay mixture due to the presence of limestone, which reduced the shrinkage of the products’ compressive strength, up to 55% for samples with a higher content of limestone (15 wt.%), and influenced the samples’ color by making them lighter than the reference sample

Exciton spectroscopy of red polydiacetylene chains in single crystals

International audienceThe absorption and emission properties of excitons are investigated in a pure “red” phase of luminescent polydiacetylene wires. The values of the binding energy (Eb = 0.556 eV) and Bohr radius (r ~ 14 Å) make the “red” exciton similar to the one of the extensively studied “blue” phase, so the conformational modifications which lead to a reordering of excited states and luminescent emission do not strongly affect the exciton structure. The opening of a thermally activated non radiative channel leads to an efficient quenching of the intense luminescence observed at low temperature