88 research outputs found
Feasibility of undertaking off-site infant eye-tracking assessments of neuro-cognitive functioning in early-intervention centres
Recent work suggests that differences in functional brain development are already identifiable in 6- to 9-month-old infants from low socio-economic status (SES) backgrounds. Investigation of early SES-related differences in neuro-cognitive functioning requires the recruitment of large and diverse samples of infants, yet it is often difficult to persuade low-SES parents to come to a university setting. One solution is to recruit infants through early intervention children’s centres (CCs). These are often located in areas of high relative deprivation to support young children. Given the increasing portability of eye-tracking equipment, assessment of large clusters of infants could be undertaken in centres by suitably trained early intervention staff. Here we report on a study involving 174 infants and their parents, carried out in partnership with CCs, exploring the feasibility of this approach, We report the processes of setting up the project and participant recruitment. We report the diversity of sample obtained on the engagement of CC staff in training and the process of assessment itself. We report the quality of the data obtained, and the levels of engagement of parents, and infants. We conclude that this approach has great potential for recruiting large and diverse samples worldwide, provides sufficiently reliable data, and is engaging to staff, parents and infants
Efficiency of scanning and attention to faces in infancy independently predict language development in a multiethnic and bilingual sample of 2-year-olds
Efficient visual exploration in infancy is essential for cognitive and language development. It allows infants to participate in social interactions by attending to faces and learning about objects of interest. Visual scanning of scenes depends on a number of factors and early differences in efficiency are likely contributing to differences in learning and language development during subsequent years. Predicting language development in diverse samples is particularly challenging, as additional multiple sources of variability affect infant performance. In this study we tested how the complexity of visual scanning in the presence or absence of a face at 6-7 months of age is related to language development at 2 years of age in a multi-ethnic and predominantly bilingual sample from diverse socio-economic backgrounds. We used Recurrence Quantification Analysis to measure the temporal and spatial distribution of fixations recurring in the same area of a visual scene. We found that in the absence of a face the temporal distribution of re-fixations on selected objects of interest (but not all) significantly predicted both receptive and expressive language scores, explaining 16 - 20% of the variance. Also, lower rate of re-fixations recurring in the presence of a face predicted higher receptive language scores, suggesting larger vocabulary in infants that effectively disengage from faces. Altogether, our results suggest that dynamic measures, which quantify the complexity of visual scanning can reliably and robustly predict language development in highly diverse samples. They suggest that selective attending to objects predicts language independently of attention to faces. As eye-tracking and language assessments were carried out in early intervention centres, our study demonstrates the utility of mobile eye-tracking setups for early detection of risk in attention and language development
Feasibility of Undertaking Off-Site Infant Eye-Tracking Assessments of Neuro-Cognitive Functioning in Early-Intervention Centres
Recent work suggests that differences in functional brain development
are already identifiable in 6- to 9-month-old infants from low
socio-economic status (SES) backgrounds. Investigation of early
SES-related differences in neuro-cognitive functioning requires
the recruitment of large and diverse samples of infants, yet it is
often difficult to persuade low-SES parents to come to a university
setting. One solution is to recruit infants through early intervention
children’s centres (CCs). These are often located in areas of
high relative deprivation to support young children. Given the
increasing portability of eye-tracking equipment, assessment of
large clusters of infants could be undertaken in centres by suitably
trained early intervention staff. Here, we report on a study involving
174 infants and their parents, carried out in partnership with
CCs, exploring the feasibility of this approach. We report the
processes of setting up the project and participant recruitment.
We report the diversity of sample obtained on the engagement of
CC staff in training and the process of assessment itself.We report
the quality of the data obtained, and the levels of engagement of
parents and infants. We conclude that this approach has great
potential for recruiting large and diverse samples worldwide,
provides sufficiently reliable data and is engaging to staff, parents
and infants
Brain responses and looking behavior during audiovisual speech integration in infants predict auditory speech comprehension in the second year of life
The use of visual cues during the processing of audiovisual (AV) speech is known to be less efficient in children and adults with language difficulties and difficulties are known to be more prevalent in children from low-income populations. In the present study, we followed an economically diverse group of thirty-seven infants longitudinally from 6–9 months to 14–16 months of age. We used eye-tracking to examine whether individual differences in visual attention during AV processing of speech in 6–9 month old infants, particularly when processing congruent and incongruent auditory and visual speech cues, might be indicative of their later language development. Twenty-two of these 6–9 month old infants also participated in an event-related potential (ERP) AV task within the same experimental session. Language development was then followed-up at the age of 14–16 months, using two measures of language development, the Preschool Language Scale and the Oxford Communicative Development Inventory. The results show that those infants who were less efficient in auditory speech processing at the age of 6–9 months had lower receptive language scores at 14–16 months. A correlational analysis revealed that the pattern of face scanning and ERP responses to audiovisually incongruent stimuli at 6–9 months were both significantly associated with language development at 14–16 months. These findings add to the understanding of individual differences in neural signatures of AV processing and associated looking behavior in infants
Beyond fixation durations: Recurrence quantification analysis reveals spatiotemporal dynamics of infant visual scanning
Standard looking-duration measures in eye-tracking data provide only general quantitative indices, while details of the spatiotemporal structuring of fixation sequences are lost. To overcome this, various tools have been developed to measure the dynamics of fixations. However, these analyses are only useful when stimuli have high perceptual similarity and they require the previous definition of areas of interest (AOIs). Although these methods have been widely applied in adult studies, relatively little is known about the temporal structuring of infant gaze-foraging behaviors such as variability of scanning over time or individual scanning patterns. Thus, to shed more light on the spatiotemporal characteristics of infant fixation sequences we apply for the first time a new methodology for nonlinear time-series analysis—the
recurrence quantification analysis (RQA). We present how the dynamics of infant scanning varies depending on the scene content during a "pop-out" search task. Moreover, we show how the normalization of RQA measures with average fixation durations provides a more detailed account of the dynamics of fixation sequences. Finally, we link the RQA measures of temporal dynamics of scanning with the spatial information about the stimuli using heat maps of recurrences without the need for defining a priori AOIs and present how infants’ foraging strategies are driven by the image content. We conclude from our findings that the RQA methodology has potential applications in the analysis of the temporal dynamics of infant visual foraging offering advantages over existing
methods
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Get a Grip: Variation in Human Hand Grip Strength and Implications for Human Evolution
Although hand grip strength is critical to the daily lives of humans and our arboreal great ape relatives, the human hand has changed in form and function throughout our evolution due to terrestrial bipedalism, tool use, and directional asymmetry (DA) such as handedness. Here we investigate how hand form and function interact in modern humans to gain an insight into our evolutionary past. We measured grip strength in a heterogeneous, cross-sectional sample of human participants (n = 662, 17 to 83 years old) to test the potential effects of age, sex, asymmetry (hand dominance and handedness), hand shape, occupation, and practice of sports and musical instruments that involve the hand(s). We found a significant effect of sex and hand dominance on grip strength, but not of handedness, while hand shape and age had a greater influence on female grip strength. Females were significantly weaker with age, but grip strength in females with large hands was less affected than those with long hands. Frequent engagement in hand sports significantly increased grip strength in the non-dominant hand in both sexes, while only males showed a significant effect of occupation, indicating different patterns of hand dominance asymmetries and hand function. These results improve our understanding of the link between form and function in both hands and offer an insight into the evolution of human laterality and dexterity
Exploring early developmental changes in face scanning patterns during the perception of audiovisual mismatch of speech cues
Young infants are capable of integrating auditory and visual information and their speech perception can be influenced by visual cues, while 5-month-olds detect mismatch between mouth articulations and speech sounds. From 6 months of age, infants gradually shift their attention away from eyes and towards the mouth in articulating faces, potentially to benefit from intersensory redundancy of audiovisual (AV) cues. Using eye tracking, we investigated whether 6- to 9-month-olds showed a similar age-related increase of looking to the mouth, while observing congruent and/or redundant versus mismatched and non-redundant speech cues. Participants distinguished between congruent and incongruent AV cues as reflected by the amount of looking to the mouth. They showed an age-related increase in attention to the mouth, but only for non-redundant, mismatched AV speech cues. Our results highlight the role of intersensory redundancy and audiovisual mismatch mechanisms in facilitating the development of speech processing in infants under 12 months of age
The Precision of the Human Hand: Variability in Pinch Strength and Manual Dexterity
Changes in hand morphology throughout human evolution have facilitated the use of forceful pad-to-pad precision grips, contributing to the development of fine motor movement and dexterous manipulation typical of modern humans. Today, variation in human hand function may be affected by demographic and/or lifestyle factors, but these remain largely unexplored. We measured pinch grip strength and dexterity in a heterogeneous cross-sectional sample of human participants (n = 556) to test for the potential effects of sex, age, hand asymmetries, hand morphology, and frequently practiced manual activities across the lifespan. We found a significant effect of sex on pinch strength, dexterity, and different directional asymmetries, with the practice of manual musical instruments, significantly increasing female dexterity for both hands. Males and females with wider hands were also stronger, but not more precise, than those with longer hands, while the thumb-index ratio had no effect. Hand dominance asymmetry further had a significant effect on dexterity but not on pinch strength. These results indicate that different patterns of hand asymmetries and hand function are influenced in part by life experiences, improving our understanding of the link between hand form and function and offering a referential context for interpreting the evolution of human dexterity
Familial longevity is associated with an attenuated thyroidal response to recombinant human thyroid stimulating hormone
Context: Longevity is associated with higher circulating levels of TSH in the absence of differences in circulating thyroid hormones (TH), as previously observed in F2 members of long-lived families (F2-LLS) and their partners (F2-Con). The mechanism underlying this observed difference remains unknown.Objective: We hypothesized that the thyroid gland of members from long-lived families are less responsive to TSH stimulation, thereby requiring higher circulating TSH levels to maintain adequate TH levels.Methods: We performed a case-control intervention study with a single intramuscular (gluteal) injection with 0.1 mg recombinant human TSH in a subgroup of 14 F2-LLS and 15 similarly aged F2-Con. They were followed for 4 days. No serious adverse events were reported. For analyses, we compared time trajectories of TSH and TH, and the ratio of TH to TSH using area under the curve (AUC) calculations.Results: The AUC free T4/AUC TSH ratio was significantly lower in F2-LLS than in F2-Con (estimated mean [95% confidence interval] 1.6 [1.2-1.9] and 2.2 [1.9-2.6], respectively, P = 0.01). The AUC thyroglobulin/AUCTSH ratio was also lower in F2-LLS than in F2-Con (median [interquartile range] 2.1 [1.4-3.6] and 3.2 [2.7-7.4], respectively, P = 0.04). We observed the same trend with the AUC free T3/AUC TSH ratio, although the difference was not statistically significant (estimated mean [95% confidence interval] 0.6 [0.4-0.7] and 0.7 [0.6-0.8], respectively, P = 0.07).Conclusions: The present findings show that members of long-living families have a lower thyroid responsivity to TSH compared with their partners.Diabetes mellitus: pathophysiological changes and therap
At the end of cosmic noon: Short gas depletion times in unobscured quasars at 1
Unobscured quasars (QSOs) are predicted to be the final stage in the
evolutionary sequence from gas-rich mergers to gas-depleted, quenched galaxies.
Studies of this population, however, find a high incidence of
far-infrared-luminous sources -suggesting significant dust-obscured star
formation-but direct observations of the cold molecular gas fuelling this star
formation are still necessary. We present a NOEMA study of CO(2-1) emission,
tracing the cold molecular gas, in ten lensed z=1-1.5 unobscured QSOs. We
detected CO(2-1) in seven of our targets, four of which also show continuum
emission (\lambda_rest = 1.3mm). After subtracting the foreground galaxy
contribution to the photometry, spectral energy distribution fitting yielded
stellar masses of 10^9-11 M_\odot, with star formation rates of 25-160 M_\odot
yr^-1 for the host galaxies. These QSOs have lower than
star-forming galaxies with the same L_IR, and show depletion times spanning a
large range (50-900 Myr), but with a median of just 90 Myr. We find molecular
gas masses in the range 2-40 x 10^9(alpha_CO/4) M_\odot, which suggest gas
fractions above ~50% for most of the targets. Despite the presence of an
unobscured QSO, the host galaxies are able to retain significant amounts of
cold gas. However, with a median depletion time of ~90 Myr, the intense burst
of star formation taking place in these targets will quickly deplete their
molecular gas reservoirs in the absence of gas replenishment, resulting in a
quiescent host galaxy. The non-detected QSOs are three of the four radio-loud
QSOs in the sample, and their properties indicate that they are likely already
transitioning into quiescence. Recent cosmological simulations tend to
overestimate the depletion times expected for these z~1 QSO-host galaxies,
which is likely linked to their difficulty producing starbursts across the
general high-redshift galaxy population.Comment: 20 pages. Accepted for publication in A&
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