I Genovesi e la conquista turca di Costantinopoli (1453). Note su Tommaso Spinola e la sua famiglia

The Liguria sources in the Genoese archive, drawn up by notaries in the Genoese settlements along the Black Sea coasts during the last centuries of the Middle Ages have striking relevance for our knowledge of social, economic, political, administrative, juridical, religious, cultural, town planning and everyday life history. In the present study we review the so far published sources concerning Caffa, Solgat in Crimea, Pera located on the Gold Horn in front of Constantinople, Chilia and Licostomo on the West coast of the Black Sea as well as places along the South coast such as Trebizond. Ultimately, in order to obtain a comprehensive view of lacking sources it will be worthy either a systematic work in the notary archive and the publication to completion of still unpublished notary sources.The Liguria sources in the Genoese archive, drawn up by notaries in the Genoese settlements along the Black Sea coasts during the last centuries of the Middle Ages have striking relevance for our knowledge of social, economic, political, administrative, juridical, religious, cultural, town planning and everyday life history. In the present study we review the so far published sources concerning Caffa, Solgat in Crimea, Pera located on the Gold Horn in front of Constantinople, Chilia and Licostomo on the West coast of the Black Sea as well as places along the South coast such as Trebizond. Ultimately, in order to obtain a comprehensive view of lacking sources it will be worthy either a systematic work in the notary archive and the publication to completion of still unpublished notary sources

Multivitamin Usage and Anemia in College Students

Multivitamin usage has been shown to be significantly prevalent in the United States amongst adult populations. Recent data suggests that women are more likely than men to regularly consume a multivitamin, and that physically active individuals are more likely to take a multivitamin than those who live sedentary lifestyles. However, there are important, documented behavioral tendencies exhibited by college students that set them apart from the general adult population in terms of dietary intake. College students often partake in poor eating habits such as regularly skipping meals, eating out frequently, eating at fast food restaurants, and snacking on processed foods. These eating behaviors predispose college adults to a variety of nutritional deficiencies. Anemia can be caused by many different factors, but some of the most common causes are a lack of iron, vitamin B12 and/or folate in the diet. These nutrients can be obtained through a variety of foods, but the inadequate eating habits found in college students may place this demographic group at an increased risk for nutritional anemia. This research project aims to evaluate sociological and behavioral differences in college students and determine whether or not these observed differences are associated with the likelihood that students choose to take a multivitamin, as well as whether or not multivitamin intake is associated with a decreased prevalence of anemia

Adenovirus infection in adult patients undergoing allogeneic hematopoietic stem cell transplant: incidence, clinical management and outcome.

ABSTRACT Adenovirus infection (ADVi) is an emergent complication in adult patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT) yet associated with poor outcome. Available data are scarce with respect to risk factors and proper management of ADVi in adults allo-HSCT, and recommendations on monitoring and preemptive therapy are consequently based on low levels of evidence. The primary aim of the study was to describe incidence of ADVi at day + 180 post-transplant in adult patients who underwent allo-HSCT in our Centre. Secondary objectives were to describe timing, clinical presentation, management and outcome of ADVi and to identify risk factors for ADVi and ADV-related mortality. In our study we analysed a large cohort of 445 adult patients undergoing allo-HSCT. Incidence at day + 180 post-transplant was: ADVi 9% (39/445), ADV viremia (ADVv) 5% (24/445) and ADVv with maximum viral load (VL max) > 10^3 cp/mL 3% (12/445). The median time to ADVi was 65 (IQR 19; 94) days. All patients with ADV VL max > 10^5 cp/mL developed disease and 50 % died. In contrast, no patients with ADV VL < 10^5 cp/mL died with/for ADVi. Overall ADVi related mortality was 1.4% (6/445) in the whole cohort, 18% (6/33) for those with ADVv and 50% (6/12) for ADVv with VL max > 10^5 cp/mL. Conclusion: in our experience ADVi was more frequent than in other cohorts and VL max > 10^5 cp/mL was associated with unfavourable outcome, so careful monitoring and early initiation of treatment are advisable

Relationship between Quarry Activity and Municipal Spatial Planning: A Possible Mediation for the Case of Sardinia, Italy

Despite its economic importance, quarrying activity for the production of natural aggregates (sand, gravel, and crushed stone) can result in overexploitation of the natural environment. This paper investigates the current state of natural and recycled aggregates in Sardinia Italy and how to limit the production of natural aggregates (NA) and increase the use of recycled aggregates (RA). The municipalities of Cagliari, Sant’Antioco and Tortolì of Sardinia, Italy, were chosen as case studies because they fall within a particular territorial context. Owing to its geographic condition, the island of Sardinia must produce its own raw materials. The results of this research show how the combined use of NA and RA can help meet local and regional demand for aggregates. This proposal is derived from a needs assessment of NA based on urban masterplans for each municipality. Possible strategies for limiting the consumption of NA, as well as the use of RA, are also described

ICCSA 2022

Producción CientíficaThe process of economic, social, and cultural development leads to relevant changes in urban areas. Urban transformations usually generate a series of public and private real estate compounds which constitute real obstacles to urban walkability. The growing attention towards the sustainable development goals established on a global scale introduced new contents in urban redevelopment policies, aimed at favoring higher levels of accessibility in the consolidated fabric, particularly that of the pedestrian type. In addition, the recent pandemic has recently reassessed the role of pedestrian mobility as a primary way of moving instead of using other means of transport. As a result, urban walkability has moved at the core of the sustainable city paradigm. More precisely, issues related to accessibility and walkability should be considered when addressing the obstacle generated by those sites that can be properly defined ‘urban enclaves’, especially when abandoned or under redevelopment. These conditions may encourage the gradual reopening of these areas for citizens. Within this framework, the Sustainable Urban Mobility Plan (SUMP) can represent a strategic tool for identifying the critical aspects to face for the creation of a new network of pedestrian routes aimed at improving urban walkability. The objective of this study is to define a set of principles and criteria, both tangible and intangible, for calculating the proximity index (PI). The PI may consequently drive urban regeneration projects also through the design of new paths for crossing the enclaves to improve urban permeability and, therefore, the level of walkabilitySardinia Foundation (CUP F74I19001040007

Smart City and Well-Being: Opinions by the Guest Editors

As with technology, the concept of the Smart City has evolved over time in line with digitisation processes and the changing needs of cities and their inhabitants. Indeed, it was in the early 1980s when discussions first arose regarding the role that information technology would play in the development of conventional urban activities [1–3]. Some thirty years later, in 2009, the concept of the Smart City was first defined when, in Rio de Janeiro, a plan came into effect that employed technological innovation and waste management to improve the quality of life in the city by minimizing wastage [4]. This is a true evolution in which the vision of the traditional city is superseded by a more modern urban reality creating an ideal, highly automated ecosystem in which Information and Communication Technologies (ICT) take on the role of the core infrastructure of a Smart City [5–7]. The technological and techno-centric revolution, currently dictated by the market, may, however, result in a decrease in inclusivity and at the same time an increase in the digital divide. Moreover, a Smart City that is too heavily based on technological solutions runs the risk of becoming disconnected from policies with a real impact on urban contexts [8]. The term ‘Smart City’ encapsulates a conception of urban reality that transcends technological boundaries and aims to raise the standards of sustainability, liveability and economic dynamism of the cities of the future [9,10]