1,139 research outputs found

    Markov, fractal, diffusion, and related models of ion channel gating. A comparison with experimental data from two ion channels

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    The gating kinetics of single-ion channels are generally modeled in terms of Markov processes with relatively small numbers of channel states. More recently, fractal (Liebovitch et al. 1987. Math. Biosci. 84:37–68) and diffusion (Millhauser et al. 1988. Proc. Natl. Acad. Sci. USA. 85:1502–1507) models of channel gating have been proposed. These models propose the existence of many similar conformational substrates of the channel protein, all of which contribute to the observed gating kinetics. It is important to determine whether or not Markov models provide the most accurate description of channel kinetics if progress is to be made in understanding the molecular events of channel gating. In this study six alternative classes of gating model are tested against experimental single-channel data. The single-channel data employed are from (a) delayed rectifier K+ channels of NG 108–15 cells and (b) locust muscle glutamate receptor channels. The models tested are (a) Markov, (b) fractal, (c) one-dimensional diffusion, (d) three-dimensional diffusion, (e) stretched exponential, and (f) expo-exponential. The models are compared by fitting the predicted distributions of channel open and closed times to those observed experimentally. The models are ranked in order of goodness-of-fit using a boot-strap resampling procedure. The results suggest that Markov models provide a markedly better description of the observed open and closed time distributions for both types of channel. This provides justification for the continued use of Markov models to explore channel gating mechanisms

    On the class SI of J-contractive functions intertwining solutions of linear differential equations

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    In the PhD thesis of the second author under the supervision of the third author was defined the class SI of J-contractive functions, depending on a parameter and arising as transfer functions of overdetermined conservative 2D systems invariant in one direction. In this paper we extend and solve in the class SI, a number of problems originally set for the class SC of functions contractive in the open right-half plane, and unitary on the imaginary line with respect to some preassigned signature matrix J. The problems we consider include the Schur algorithm, the partial realization problem and the Nevanlinna-Pick interpolation problem. The arguments rely on a correspondence between elements in a given subclass of SI and elements in SC. Another important tool in the arguments is a new result pertaining to the classical tangential Schur algorithm.Comment: 46 page

    Whirl mappings on generalised annuli and the incompressible symmetric equilibria of the dirichlet energy

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    In this paper we show a striking contrast in the symmetries of equilibria and extremisers of the total elastic energy of a hyperelastic incompressible annulus subject to pure displacement boundary conditions.Indeed upon considering the equilibrium equations, here, the nonlinear second order elliptic system formulated for the deformation u=(u1,…,uN) : EL[u,X]=⎧⎩⎨⎪⎪Δu=div(P(x)cof∇u)det∇u=1u≡φinX,inX,on∂X, where X is a finite, open, symmetric N -annulus (with N≥2 ), P=P(x) is an unknown hydrostatic pressure field and φ is the identity mapping, we prove that, despite the inherent rotational symmetry in the system, when N=3 , the problem possesses no non-trivial symmetric equilibria whereas in sharp contrast, when N=2 , the problem possesses an infinite family of symmetric and topologically distinct equilibria. We extend and prove the counterparts of these results in higher dimensions by way of showing that a similar dichotomy persists between all odd vs. even dimensions N≥4 and discuss a number of closely related issues

    Twist-3 Distribute Amplitude of the Pion in QCD Sum Rules

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    We apply the background field method to calculate the moments of the pion two-particles twist-3 distribution amplitude (DA) ϕp(ξ)\phi_p(\xi) in QCD sum rules. In this paper,we do not use the equation of motion for the quarks inside the pion since they are not on shell and introduce a new parameter m0pm_0^p to be determined. We get the parameter m0p≈1.30GeVm_0^p\approx1.30GeV in this approach. If assuming the expansion of ϕp(ξ)\phi_p(\xi) in the series in Gegenbauer polynomials Cn1/2(ξ)C_n^{1/2}(\xi), one can obtain its approximate expression which can be determined by its first few moments.Comment: 12 pages, 3 figure

    Rare Kaon Decays in the 1/Nc1/N_c-Expansion

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    We study the unknown coupling constants that appear at order p4p^4 in the Chiral Perturbation Theory analysis of K→πγ∗→πl+l−K \to \pi \gamma^* \to \pi l^+ l^-, K+−→π+−γγK^{+-} \to \pi^{+-} \gamma \gamma and K→ππγK \to \pi \pi \gamma decays. To that end, we compute the chiral realization of the ΔS = 1\Delta S \, = \, 1 Hamiltonian in the framework of the 1/Nc1/N_c-expansion of the low-energy action. The phenomenological implications are also discussed.Comment: 18 pages, LaTeX, CPT-92/P.279

    On Two-Body Decays of A Scalar Glueball

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    We study two body decays of a scalar glueball. We show that in QCD a spin-0 pure glueball (a state only with gluons) cannot decay into a pair of light quarks if chiral symmetry holds exactly, i.e., the decay amplitude is chirally suppressed. However, this chiral suppression does not materialize itself at the hadron level such as in decays into π+π−\pi^+\pi^- and K+K−K^+K^-, because in perturbative QCD the glueball couples to two (but not one) light quark pairs that hadronize to two mesons. Using QCD factorization based on an effective Lagrangian, we show that the difference of hadronization into ππ\pi\pi and KKKK already leads to a large difference between Br(π+π−){\rm Br} (\pi^+\pi^-) and Br(K+K−){\rm Br}(K^+K^-), even the decay amplitude is not chirally suppressed. Moreover, the small ratio of R=Br(ππ)/Br(KKˉ)R={\rm Br}(\pi\pi)/{\rm Br}(K\bar K) of f0(1710)f_0(1710) measured in experiment does not imply f0(1710)f_0(1710) to be a pure glueball. With our results it is helpful to understand the partonic contents if Br(ππ){\rm Br}(\pi\pi) or Br(KKˉ){\rm Br}(K\bar K) is measured reliably.Comment: revised versio

    Survey of nucleon electromagnetic form factors

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    A dressed-quark core contribution to nucleon electromagnetic form factors is calculated. It is defined by the solution of a Poincare' covariant Faddeev equation in which dressed-quarks provide the elementary degree of freedom and correlations between them are expressed via diquarks. The nucleon-photon vertex involves a single parameter; i.e., a diquark charge radius. It is argued to be commensurate with the pion's charge radius. A comprehensive analysis and explanation of the form factors is built upon this foundation. A particular feature of the study is a separation of form factor contributions into those from different diagram types and correlation sectors, and subsequently a flavour separation for each of these. Amongst the extensive body of results that one could highlight are: r_1^{n,u}>r_1^{n,d}, owing to the presence of axial-vector quark-quark correlations; and for both the neutron and proton the ratio of Sachs electric and magnetic form factors possesses a zero.Comment: 43 pages, 17 figures, 12 tables, 5 appendice

    Schur functions and their realizations in the slice hyperholomorphic setting

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    we start the study of Schur analysis in the quaternionic setting using the theory of slice hyperholomorphic functions. The novelty of our approach is that slice hyperholomorphic functions allows to write realizations in terms of a suitable resolvent, the so called S-resolvent operator and to extend several results that hold in the complex case to the quaternionic case. We discuss reproducing kernels, positive definite functions in this setting and we show how they can be obtained in our setting using the extension operator and the slice regular product. We define Schur multipliers, and find their co-isometric realization in terms of the associated de Branges-Rovnyak space
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