Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function

We thank Andres Aguilera for providing the pCYC-LacZ plasmid for the GLRO experiments, and Szilvia Minorits for technical assistance. This work was also supported by grants from the National Research, Development and Innovation Office: GINOP-2.3.2-15-2016-00001 and GINOP-2.3.2-15-2016-00024.Peer reviewedPublisher PD

Tremor in motor neuron disease may be central rather than peripheral in origin

BACKGROUND AND PURPOSE: Motor neuron disease (MND) refers to a spectrum of degenerative diseases affecting motor neurons. Recent clinical and post-mortem observations have revealed considerable variability in the phenotype. Rhythmic involuntary oscillations of the hands during action, resembling tremor, can occur in MND, but their pathophysiology has not yet been investigated. METHODS: A total of 120 consecutive patients with MND were screened for tremor. Twelve patients with action tremor and no other movement disorders were found. Ten took part in the study. Tremor was recorded bilaterally using surface electromyography (EMG) and triaxial accelerometer, with and without a variable weight load. Power spectra of rectified EMG and accelerometric signal were calculated. To investigate a possible cerebellar involvement, eyeblink classic conditioning was performed in five patients. RESULTS: Action tremor was present in about 10% of our population. All patients showed distal postural tremor of low amplitude and constant frequency, bilateral with a small degree of asymmetry. Two also showed simple kinetic tremor. A peak at the EMG and accelerometric recordings ranging from 4 to 12 Hz was found in all patients. Loading did not change peak frequency in either the electromyographic or accelerometric power spectra. Compared with healthy volunteers, patients had a smaller number of conditioned responses during eyeblink classic conditioning. CONCLUSIONS: Our data suggest that patients with MND can present with action tremor of a central origin, possibly due to a cerebellar dysfunction. This evidence supports the novel idea of MND as a multisystem neurodegenerative disease and that action tremor can be part of this condition

QCD thermodynamics with continuum extrapolated Wilson fermions II

We continue our investigation of 2+1 flavor QCD thermodynamics using dynamical Wilson fermions in the fixed scale approach. Two additional pion masses, approximately 440 MeV and 285 MeV, are added to our previous work at 545 MeV. The simulations were performed at 3 or 4 lattice spacings at each pion mass. The renormalized chiral condensate, strange quark number susceptibility and Polyakov loop is obtained as a function of the temperature and we observe a decrease in the light chiral pseudo-critical temperature as the pion mass is lowered while the pseudo-critical temperature associated with the strange quark number susceptibility or the Polyakov loop is only mildly sensitive to the pion mass. These findings are in agreement with previous continuum results obtained in the staggered formulation.Comment: 19 pages, 13 figures, published versio

Chiral damping of magnetic domain walls

Structural symmetry breaking in magnetic materials is responsible for a variety of outstanding physical phenomena. Examples range from the existence of multiferroics, to current induced spin orbit torques (SOT) and the formation of topological magnetic structures. In this letter we bring into light a novel effect of the structural inversion asymmetry (SIA): a chiral damping mechanism. This phenomenon is evidenced by measuring the field driven domain wall (DW) motion in perpendicularly magnetized asymmetric Pt/Co/Pt trilayers. The difficulty in evidencing the chiral damping is that the ensuing DW dynamics exhibit identical spatial symmetry to those expected from the Dzyaloshinskii-Moriya interaction (DMI). Despite this fundamental resemblance, the two scenarios are differentiated by their time reversal properties: while DMI is a conservative effect that can be modeled by an effective field, the chiral damping is purely dissipative and has no influence on the equilibrium magnetic texture. When the DW motion is modulated by an in-plane magnetic field, it reveals the structure of the internal fields experienced by the DWs, allowing to distinguish the physical mechanism. The observation of the chiral damping, not only enriches the spectrum of physical phenomena engendered by the SIA, but since it can coexists with DMI it is essential for conceiving DW and skyrmion devices

Charmonium spectral functions from 2+1 flavour lattice QCD

Finite temperature charmonium spectral functions in the pseudoscalar and vector channels are studied in lattice QCD with 2+1 flavours of dynamical Wilson quarks, on fine isotropic lattices (with a lattice spacing of 0.057 fm), with a non-physical pion mass of $m_{\pi} \approx$ 545 MeV. The highest temperature studied is approximately $1.4 T_c$. Up to this temperature no significant variation of the spectral function is seen in the pseudoscalar channel. The vector channel shows some temperature dependence, which seems to be consistent with a temperature dependent low frequency peak related to heavy quark transport, plus a temperature independent term at \omega>0. These results are in accord with previous calculations using the quenched approximation.Comment: 17 pages, 9 figures, 2 table

Causal links between external contingencies of self-worth and mindfulness

Outcome research confirming the salutary effects of mindfulness-based interventions has proliferated in the last fifteen years. In contrast, there has been very little research into intra-individual factors that may enhance or inhibit mindfulness. The present study examined a proposal by Brown, Ryan and Creswell (2007a) that external contingent self-worth may act as an inhibiting factor of mindfulness. Undergraduate participants performed two reading tasks; one under neutral conditions and one under the influence of an academic ego-threat. Momentary mindfulness levels were measured retrospectively following both reading tasks. It was expected that levels of academic competence contingent self-worth would predict changes in momentary mindfulness levels between the ego-threat and neutral condition, and, in addition, that worry would mediate the relationship. The study findings supported both hypotheses. The theoretical implications of the study are discussed in relation to the salience of self-investment in present moment events as a controlling variable of levels of momentary mindfulness

Antibody-related movement disorders - a comprehensive review of phenotype-autoantibody correlations and a guide to testing

Background: Over the past decade increasing scientific progress in the field of autoantibody–mediated neurological diseases was achieved. Movement disorders are a frequent and often prominent feature in such diseases which are potentially treatable. Main body: Antibody-mediated movement disorders encompass a large clinical spectrum of diverse neurologic disorders occurring either in isolation or accompanying more complex autoimmune encephalopathic diseases. Since autoimmune movement disorders can easily be misdiagnosed as neurodegenerative or metabolic conditions, appropriate immunotherapy can be delayed or even missed. Recognition of typical clinical patterns is important to reach the correct diagnosis. Conclusion: There is a growing number of newly discovered antibodies which can cause movement disorders. Several antibodies can cause distinctive phenotypes of movement disorders which are important to be aware of. Early diagnosis is important because immunotherapy can result in major improvement. In this review article we summarize the current knowledge of autoimmune movement disorders from a point of view focused on clinical syndromes. We discuss associated clinical phenomenology and antineuronal antibodies together with alternative etiologies with the aim of providing a diagnostic framework for clinicians considering underlying autoimmunity in patients with movement disorders