The local functors of points of Supermanifolds

We study the local functor of points (which we call the Weil-Berezin functor) for smooth supermanifolds, providing a characterization, representability theorems and applications to differential calculus

A phase II study of primary dose-dense sequential doxorubicin plus cyclophosphamide and docetaxel in cT4 breast cancer

Background: Dose-dense chemotherapy with anthracyclines and taxanes has improved either disease free survival or overall survival in high risk patients with early breast cancer. Patients and Methods: The activity and safety of a dose-dense schedule (q14 days) of adriamycin 60 mg/sqm and cyclophosphamide 600 mg/sqm (AC) x 4 cycles followed by docetaxel 75 mg/sqm for 4 cycles with hematopoietic support in patients with stage IIIB breast cancer was explored. Patients with ER >= 10% tumors received concomitant endocrine therapy with 3-month triptorelin and letrozole. Results: Fifteen patients with histologically proven cT4b (three patients) and cT4d (twelve patients) MO breast cancer were enrolled. Median age was 48 years (range 25-66). Eight clinical responses including one pathological complete remission (pCR), three stable disease (including minor responses) and four progression of disease, one during AC and three during taxotere, were observed. Four patients had grade 3-4 non hematological toxicities and all except one discontinued treatment. Conclusion: Due to the high rate of progressive disease, this schedule should not represent a standard option in cT4 breast cancer

Approche empirique des difficultés de compréhension en traduction, mises en évidence par la méthode d'observation du raisonnement á voix haute (Protocole Verbal - PV)

Le présent travail a pour objet, premièrement, de mieux interpréter le processus de compréhension, et, deuxièmement, de prendre conscience des difficultés de compréhension, ce qui, ultérieurement, permettra de résoudre des ambiguïtés au moyen de différentes stratégies.Departamento de Lenguas y Literaturas Moderna

Approche empirique des difficultés de compréhension en traduction, mises en évidence par la méthode d'observation du raisonnement á voix haute (Protocole Verbal - PV)

Le présent travail a pour objet, premièrement, de mieux interpréter le processus de compréhension, et, deuxièmement, de prendre conscience des difficultés de compréhension, ce qui, ultérieurement, permettra de résoudre des ambiguïtés au moyen de différentes stratégies.Departamento de Lenguas y Literaturas Moderna

On the influence of virtual camber effect on airfoil polars for use in simulations of Darrieus wind turbines

Darrieus vertical-axis wind turbines are experiencing renewed interest from researchers and manufacturers, though their efficiencies still lag those of horizontal-axis wind turbines. A better understanding of their aerodynamics is required to improve on designs, for example through the development of more accurate low-order (e.g. blade element momentum) models. Many of these models neglect the impact of the curved paths that are followed by blades on their performance. It has been theorized that the curved streamlines of the flow impart a virtual camber and incidence on them, giving a performance analogous to a cambered blade in a rectilinear flow. To test the extent of this effect, wind tunnel experiments have been conducted in a rectilinear flow to obtain lift and drag for three airfoils: a NACA 0018 and two conformal transforms of the profile. The transformed airfoils exhibit the virtual camber that the theory predicts is imparted to a NACA 0018 when used in a Darrieus turbine with blade chord-to-turbine radius ratios, c/R, of 0.114 and 0.25. A parallel computational fluid dynamics campaign has been conducted to study the aerodynamic behavior of the same blades in curvilinear flow in Darrieus-like motion with c/R = 0.114 and 0.25, at tip-speed ratios of 2.1 and 3.1, using novel techniques to obtain blade effective angles of attack. The analysis confirms that the theory holds, with the wind tunnel results for the NACA 0018 being analogous to numerical results for the relevant cambered airfoils. In addition, turbine performance is calculated using computational fluid dynamics and a blade element momentum code, for each of the blades in turn. The computational fluid dynamics results for the NACA 0018 agree closely to blade element momentum results for the equivalent cambered airfoil where c/R = 0.25, for both turbine power and blade tangential forces. Agreement between the two methods using geometrically identical blades is poor at both the blade and turbine level for c/R = 0.25. It is concluded that when modeling a Darrieus rotor using blade element momentum methods, applying experimental data for the profile used in the turbine will yield inaccurate results if the c/R ratio is high, in such cases it is necessary to select a profile based on the virtual shape of the blades