Identification of a Common Pharmacophore for Binding to MMP2 and RGD Integrin: Towards a Multitarget Approach to Inhibit Cancer Angiogenesis and Metastasis

During tumor angiogenesis different growth factors, cytokines and other molecules interact closely with each other to facilitate tumor cell invasion and metastatic diffusion. The most intensively studied as molecular targets in anti-angiogenic therapies are vascular endothelial growth factor (VEGF) and related receptors, integrin receptors and matrix metalloproteinases (MMPs). Considering the poor efficacy of cancer angiogenesis monotherapies, we reasoned combining the inhibition of α(v)β(3) and MMP2 as a multitarget approach to deliver a synergistic blockade of tumor cell migration, invasion and metastasis. Accordingly, we identified a common pharmacophore in the binding cavity of MMP2 and α(v)β(3), demonstrating such approach with the design, synthesis and bioassays of tyrosine-derived peptidomimetics carrying the necessary functional groups to bind to key pharmacophoric elements of MMP2 and α(v)β(3) RGD integrin

What Is Street Art?

What is street art? This paper offers a definition of street art as an art kind or art form based on its essential value: its subversiveness. It argues that street art is essentially subversive in virtue of using public space as a technical resource. By hijacking a portion of the urban landscape with its colourful forms and witty designs, street art challenges familiar ways of practising the city, while creating a ‘temporary autonomous zone’ of free expression. There, corporate control over the city’s visible surfaces is ridiculed and people reclaim their right to use the city. In this sense, street art functions as a carnivalesque tactic of social resistance, favouring the emergence of alternative ways to imagine our urban life and our uses of public space. By considering its subversiveness, one can also explain how street art (i) significantly differs from official public art; (ii) includes graffiti as its original and most radical style.12

Radically Rethinking Copyright in the Arts: A Philosophical Approach by James O. Young

A book review of James O. Young, Radically Rethinking Copyright in the Arts: A Philosophical Approach. New York: Routledge, 2021, 184 pp. ISBN 978-0-367–52183–7.757

Thermodynamic Assessment on the Integration of Thermo-Electric Modules in a Wood Fireplace

The growing demand for electricity produced from renewable sources and the development of new technologies for the combustion of biomass, arose a growing interest on the possible coupling of thermoelectric modules with stove-fireplaces. The current thermoelectric generators have a solid structure, do not produce noise, do not require maintenance and can be used for the recovery of waste heat or excess, at the same time they hold a very low conversion efficiency and they need an adequate cooling system. Nevertheless, they still hold a cost, which is still too high to make them attractive. Nonetheless, if the modules are applied to a heat source which otherwise would be wasted, the attractiveness of the solution certainly rises. In this study, a thermodynamic analysis of a stove-fireplace is presented, considering both combustion process and the flame – walls heat transfer of the. A design solution for a concentrator device to funnel the wasted heat from the fireplace to the thermo-electric modules is also presented

Foot Orthosis and Sensorized House Slipper by 3D Printing

In clinical practice, specific customization is needed to address foot pathology, which must be disease and patient-specific. To date, the traditional methods for manufacturing custom functional Foot Orthoses (FO) are based on plaster casting and manual manufacturing, hence orthotic therapy depends entirely on the skills and expertise of individual practitioners. This makes the procedures difficult to standardize and replicate, as well as expensive, time-consuming and material-wasting, as well as difficult to standardize and replicate. 3D printing offers new perspectives in the development of patient-specific orthoses, as it permits addressing all the limitations of currently available technologies, but has been so far scarcely explored for the podiatric field, so many aspects remain unmet, especially for what regards customization, which requires the definition of a protocol that entails all stages from patient scanning to manufacturing

New development: Directly elected mayors in Italy: creating a strong leader doesn’t mean creating strong leadership

More than 20 years after their introduction, directly elected mayors are key players in Italian urban governance. This article explains the main effects of this reform on local government systems and provides lessons for other countries considering directly elected mayors

Association between adverse childhood experiences and suicidal behavior in schizophrenia spectrum disorders: A systematic review and meta-analysis

Assessing and managing suicide behaviors is highly relevant to individuals with schizophrenia spectrum disorders. Our study aims to assess the association between adverse childhood experiences and suicidal behaviors in individuals with schizophrenia spectrum disorders. We included observational studies comparing the probability of suicide behaviors in adults with schizophrenia spectrum disorders exposed and unexposed to adverse childhood experiences. Odds ratio estimates were obtained by pooling data using a random-effects pairwise meta-analysis. Standardized criteria were used to assess the strength of the association of the pooled estimate. We found 21 eligible studies reporting outcomes for 6257 individuals from 11 countries. The primary outcome revealed an association between any suicidal behavior and adverse childhood experiences, which resulted "highly suggestive" according to validated Umbrella Criteria. Similarly, a positive association was confirmed for suicidal ideation and suicide attempt and for any subtype of adverse childhood experience. This meta-analysis showed that exposure to adverse childhood experiences strongly increases the probability of suicide behaviors in people with schizophrenia spectrum disorders

Haptic Glove and Platform with Gestural Control For Neuromorphic Tactile Sensory Feedback In Medical Telepresence

Advancements in the study of the human sense of touch are fueling the field of haptics. This is paving the way for augmenting sensory perception during object palpation in tele-surgery and reproducing the sensed information through tactile feedback. Here, we present a novel tele-palpation apparatus that enables the user to detect nodules with various distinct stiffness buried in an ad-hoc polymeric phantom. The contact force measured by the platform was encoded using a neuromorphic model and reproduced on the index fingertip of a remote user through a haptic glove embedding a piezoelectric disk. We assessed the effectiveness of this feedback in allowing nodule identification under two experimental conditions of real-time telepresence: In Line of Sight (ILS), where the platform was placed in the visible range of a user; and the more demanding Not In Line of Sight (NILS), with the platform and the user being 50 km apart. We found that the entailed percentage of identification was higher for stiffer inclusions with respect to the softer ones (average of 74% within the duration of the task), in both telepresence conditions evaluated. These promising results call for further exploration of tactile augmentation technology for telepresence in medical interventions

Determinación de la densidad de potencia irradiada por estaciones bases GSM 1900 mediante la transformada discreta wavelet

Para conocer el nivel de energía electromagnética o específicamente la densidad de potencia que irradian distintas fuentes de emisión de radio frecuencia, y determinar si cumplen con la normativa vigente, se efectúan mediciones con distintas técnicas tanto en banda angosta como en banda ancha. Muchas señales de interés como las de telefónía móvil poseen características no estacionarias o transitorias como derivas, tendencias y cambios abruptos; siendo éstas a menudo la parte más importante de la señal. Nuestra línea de trabajo analiza diferentes tipos de modulación (tanto analógica como digital) para determinar la densidad de potencia irradiada por diferentes emisores individualmente y simultáneamente. El interés se centra en las emisiones de una Estación Base de Telefonía Móvil basada en el estándar GSM (Glogal System for Mobile Communication) 1900, empleando la Transformada Discreta Wavelet (TDW). La Transformada Discreta Wavelet resulta ser una aproximación más flexible que la Transformada Discreta de Fourier, para determinar con mayor exactitud el tiempo y la frecuencia por medio de la variación del tamaño de las ventanas. El análisis de la señal adquirida empleando la TDW nos permite determinar tiempo, frecuencia y niveles de energía en dicho ancho de banda.Eje: Procesamiento de señales y sistemas en tiempo realRed de Universidades con Carreras en Informática (RedUNCI