Importance of screening for urinary tract infection in African Black diabetics

Urinary tract infections are common and often latent in diabetic patients. The objective of this study was to determinethe frequency of urinary tract infections and the organisms responsible.This is a descriptive type prospective study conducted in the Endocrinology and Diabetology ward of Donka UniversityHospital. All diabetic patients hospitalised from January 3rd to April 4th 2013 were included in the study.Two hundred and sixty-two diabetics had been screened, 64 (24.42%) had a urinary tract infection 41 women (64%)and 23 men (36%). The average age was 56.48 16.3 years with a range of 20-90 years. Urinary tract infections weremore frequent between the ages of 45 and 74 (67.20%). Sixty patients were married, four were single. Fifty-six patientswere type 2 diabetes against eight type I diabetes. Urine test strips showed 60 cases of pyuria, 36 cases of nitruria, 21cases of proteinuria and three cases of hematuria. Organisms identified were: Escherichia coli in 31 cases (48.43%): 25women and six men; Klebsiella pneumoniae in 14 cases (21.87%): nine women and five men; Staphylococcus aureusin 11 cases (17.18%): six women and five men; and Proteus mirabilis in eight cases (12.51%): two women and six men.The clinical manifestations were: asymptomatic bacteriuria in 57 cases (89.06%); acute cystitis in five cases (7.81%); andacute urethritis in two cases (3.13%).Urinary infection in African diabetics is very common. It requires a systematic screening with urine test strips becauseasymptomatic types are by far the most common. This would allow early treatment and avoid serious complications

Propagation du Lyssavirus chez les petits mammifères (Muridae et Soricidae) dans la Préfecture de Kindia, République de Guinée (Basse Guinée)

L’étude porte sur la propagation du Lyssavirus chez les petits mammifères dans la Préfecture de Kindia (Basse Guinée) a été réalisée entre avril 2015 et mars 2016 dans les différents biotopes (Maisons habitées, Forêts-Buissons, Champs agricoles, Entrepôts et Berges) et qui a pour objectif: Contribuée à l’amélioration de l’état de santé de la population. Pendant cette période d’étude, 412 rongeurs repartis en 12 espèces ont été capturées à savoir le rat d’herbe-Arvicanthis rufinus, les rats-Cricetomys gambianus, les rats-Crocidurinae spp., les souris rayées-Lemniscomys striatus, Lophuromys ansorgei, Lophuromys sikapusi, le rat à mamelles multiples-Mastomys spp., souris de maison-Mus musculus, Pelomys fallax, le rat de forêt-Praomys rostratus, le rat noir-Rattus rattus et le Malacomys edyardsi spp. Les plus répandus sont les Mastomys, Rattus rattus, Mus musculus et Cricetomys gambianus. En saison sèche, le nombre de rongeurs capturés dans la préfecture de Kindia a atteint 292 (71%) contre 120 (29%) rongeurs en saison pluvieuse. Pour des fins de recherches virologiques, le cerveau de 221 rongeurs a été prélevé et analysé parmi eux, 18 (8%) ont été trouvé porteurs de l’ARN de Lyssavirus. English title: Spread of Lyssavirus among small mammals (Muridae and Soricidae) in Kindia prefecture, Republic of Guinea (Lower Guinea) The study focuses on the spread of Lyssavirus among small mammals in the Prefecture of Kindia (Lower Guinea) was carried out between April 2015 and March 2016 in the different biotopes (inhabited houses, Forests-Bushes, Agricultural fields, Warehouses and Banks) and which has for objective: Contributed to the improvement of the state of health of the population. During this period, 412 rodents were caught in 12 species including the grass rat-Arvicanthis rufinus, the Cricetomys gambianus-rats, the Crocidurinae spp rats, striped mice Lemniscomys striatus, Lophuromys ansorgei, Lophuromys sikapusi, the multiple-teat rat-Mastomys spp., house mouse-Mus musculus, Pelomys fallax, forest rat-Praomys rostratus, black rat-Rattus rattus, and Malacomys edwardsi spp. The most common are: Mastomys spp., Rattus rattus, Mus musculus and Cricetomys gambianus. In the dry season, the number of rodents caught in the prefecture of Kindia reached 292 (71%) against 120 (29%) rodents caught during the rainy season. For virological research purposes, the brain of 221 rodents was collected and analyzed among them 18 rodents (8%) were found to carry Lyssavirus RNA

Kidney failure screening in the general population of rural Africa

Kidney failure is a silently progressive disease too often unknown to the patients. The objective of this study was to assess the impact of kidney disease in Conakry so as to develop strategies for early detection and prevention.This was a descriptive-type prospective study carried out over six months, from January 31 to July 31, 2012. The study was carried out in two areas: In health facilities where the population were at a higher risk of developing kidney disease (diabetes, uropathies, infectious diseases and HIV, hypertension and cardiovascular disease), and in an apparently healthy population. In the study we included black subjects hospitalised in different targeted wards, as well as fully active apparently healthy subjects of the general population. Renal function was assessed with the simplified MDRD formula. Data collection included clinical parameters: Blood pressure, weight, height and blood laboratory parameters (creatinine, glucose) and urine (urine dipstick, 24h quantitative proteinuria).One hundred and ninety-nine patients were selected for the study: 117 men and 82 women ageing from 20 to 90 years. The prevalence of renal failure was 59% in the population at risk, with 53.3% of men and 16% in apparently healthy population with 60% of men with a statistically significant difference: p = 0.00000001. Proteinuria was observed in 86 patients in the population at risk against 19 in the healthy population

Epidemiology of chronic kidney diseases in the Republic of Guinea; future dialysis needs

Background: Chronic kidney disease (CKD) is increasing worldwide and can lead to end-stage renal disease (ESRD). Objectives: Because few patients with ESRD in the Republic of Guinea have access to haemodialysis, we retrospectively evaluated the prevalence of CKD, ESRD and access to supportive therapies. Patients and Methods: 579 CKD patients (304 males; mean age: 44 ± 16 years) were admitted into Conakry nephrology department, the only centre in the Republic of Guinea, between 2009 and 2013. Most patients (63%) resided within Conakry (the capital), 12.5% came from lower Guinea, 11.7% from middle Guinea, 7.9% from upper Guinea and 4.8% from forest Guinea. Results: Reasons for referral were increased serum creatinine (49.5%), hypertension (27%) and diffuse edema (17%). Also, 11% were diabetic, 12.5% were smokers, 17% were HIV-positive, 8.3% were HBV-positive and 15% were HCV-positive. The most frequent symptom at admission was nausea/vomiting (56%). Upon admission, 70.5% of patients already had ESRD. Although no kidney biopsies were performed it was assumed that 34% and 27% of patients had vascular nephropathy and chronic glomerulonephritis, respectively. Of the 385 ESRD patients, only 140 (36.3%) had access to haemodialysis (two sessions/week, 4 hours each). Most patients that received haemodialysis resided within the Conakry region (P < 0.0001). There were significant associations between mortality and (i) terminal stage of CKD (P = 0.0005), (ii) vascular nephropathy (P = 0.002), and (iii) nephropathies of unknown origin (P = 0.0001). Conclusions: A fourfold increase in haemodialysis machines is needed in Conakry, plus four new nephrology/haemodialysis centres within the Republic of Guinea, each holding ≥30 haemodialysis machines

Modélisation du potentiel éolien et choisir les éoliennes optimales les plus productives au site de Télico – Mamou, République de Guinée

International audienceThis work concerns the modeling of the wind potential of the site of Télico-Mamou. This research allowed us to determine the wind roses during the two seasons and to choose the most adapted wind for the site of Télico. Thus, during the dry season the wind blows from the North-East and the rainy season comes from the South-West. The analysis of the wind data during the 30 years shows that the wind speed from 1981 is higher than 2m/s, except for the years 1990 to 1998 and 2006 to 2008. Thus, the Weibull distribution showed that the wind potential during the dry season (24W/m² K=2.66 A=3.3m/s and Vmoy = 2.98 at 20m) is higher than the wind potential during the rainy season (11W/m² K=2.88 A=2.6 and Vmoy = 2.36m/s at 20m). We used two methods to select the appropriate wind turbine for the site, namely: the method of calculating the power output of a wind turbine and the method using RETScreen. The results all showed that the adapted high power (S.64/1000) and low power (STE/500W) wind turbines correspond to those with lower starting and rated speeds.Ce travail porte sur la modélisation du potentiel éolien du site de Télico- Mamou. Cette recherche nous a permis de déterminer des roses de vent pendant les deux saisons et de choisir l’éolien le plus adapté au site de Télico. Ainsi, pendant la saison sèche le vent souffle du Nord-Est et celle pluvieuse provient du Sud-Ouest. L’analyse des données du vent durant les 30 ans montre que la vitesse du vent à partir de 1981 est supérieure à 2m/s, exception faite pour les années 1990 à 1998 et de 2006 à 2008. Ainsi, la distribution de Weibull a montré que le potentiel éolien pendant la saison sèche (24W/m² K=2,66 A=3,3m/s et Vmoy = 2,98 à 20m) est supérieur au potentiel éolien pendant la saison des pluies (11W/m² K=2,88 A=2,6 et Vmoy = 2,36m/s à 20m). Nous avons utilisé deux méthodes de choix de l’éolienne adaptée au site, à savoir: la méthode de calcul de la puissance à la sortie d’une éolienne et la méthode utilisant RETScreen. Les résultats ont tous montré que les éoliennes de grande puissance (S.64/1000) et celles de petite puissance (STE/500W) adaptées correspondent à celles qui ont des vitesses de démarrage et nominales plus faibles

Quality of life of patients with end-stage renal disease in Guinea

This questionnaire-based study included 69 patients from the Republic of Guinea with end-stage renal disease (ESRD) and was conducted over 12 months. The factors that affected their quality of life (QoL) were determined. The included ESRD patients had an estimated creatinine clearance (CCr) of <15 mL/minute using MDRD formula. We used the SF36 question-naire and classified the results into two groups: Scores <50/100 as poor QoL and scores 50/100 as good QoL. Factors that determined the QoL were cessation of all activities and additional effort required, severe or mild pain, good or bad health, and reduced or not reduced social and physical activities. Of the 69 patients, 32 (46.3%) had a good QoL and 37 (53.7%) had a poor QoL. The estimated CCr was similar in both groups. The average age of the poor QoL group was 54 ± 4 years, the good-QoL group′s average age was of 47.6 ± 4 years (P = 0.01). Patients with a good QoL had better overall health, but this was not statistically significant [OR = 0.42 (0.14-1.28); P = 0.14]. Patients with a poor QoL had more severe pain (P = 0.002); however, good QoL did not protect against mental problems [OR = 46.67 (8.18-351.97); P = 0.0001]. Mental status (P = 0.01) and social activities (P = 0.001) were reduced, and there were more comorbidities in the poor-QoL group (29.7%, with >4, P = 0.01). Good QoL was associated with younger age, fewer comorbidities, less severe physical pain, and fewer physical or social limitations. QoL could be increased by improving comorbidity treatments, giving more effective pain control, and providing more assistance for social and physical limitations