Indice dei manoscritti

Indice dei manoscritti del volume I "Sonetti et canzoni" di Iacopo Sannazaro (Gargnano del Garda, 20-21 settembre 2018), a cura di Gabriele Baldassari e Michele Comelli, 202

Le ecfrasi encomiastiche nella storia dell’“Inamoramento de Orlando” di Boiardo

The essay focuses on the two dynastic ecphrases in Boiardo's poem (II XXV and XXVII), highlighting some aspects of the way in which they are structured, with the intention of better understanding their porpose, their possible chronological placement and their relationship to the compositional events of the poem. According to the interpretation proposed, the ecphrasis of Canto XXV aims not only at correcting the historical errors in the genealogy that concludes Canto XXI, but at the primary intent of glorifying the Este white eagle and its role as a historical ally of the Church, probably at a time of difficulty in relations with Pope Sixtus IV, which could coincide with the early 1480s, not necessarily with the outbreak of war with Venice. It is suggested that this ecphrasis was conceived together with that of Canto XXVII, which exalts the dynasty of the Aragonese, and in particular the figure of Alfonso, Duke of Calabria, identified since the formation of the League among Milan, Florence and Naples as a key figure in the preservation of the Estense State. Thus it is discussed the possibility that the first version of the Inamoramento included the so-called octave II XXVII 56bis, extolling Alfonso's military exploits, contrary to the opinion of prominent Boiardists, and in particular Antonia Tissoni Benvenuti and Cristina Montagnani, but according to Tiziano Zanato.Il contributo si concentra sulle due ecfrasi dinastiche nel poema di Boiardo (II XXV e XXVII), mettendo in rilievo alcuni aspetti del modo in cui sono costruite, con l’intento di comprendere meglio la loro funzione, la loro possibile collocazione cronologica e il loro rapporto con le vicende compositive del poema. Secondo la lettura proposta, l’ecfrasi del canto XXV non risponde solo alla necessità di correggere gli errori storici presenti nella genealogia che chiude il canto xxi, ma all’intento primario di glorificare l’aquila bianca estense e il suo ruolo di storico alleato della Chiesa, probabilmente in un momento di difficoltà nei rapporti con papa Sisto IV, che può essere fatto coincidere con i primi anni Ottanta, non necessariamente con lo scoppio della guerra con Venezia. Si propone l’ipotesi che questa ecfrasi sia stata concepita insieme a quella del canto XXVII che esalta la dinastia degli Aragonesi, e in particolare la figura di Alfonso duca di Calabria, individuato fin dalla formazione della Lega tra Milano, Firenze e Napoli come personaggio fondamentale per la salvaguardia dello Stato estense. Si discute così la possibilità che nella prima versione dell’Inamoramento fosse presente la cosiddetta ottava II XXVII 56bis, che esalta le imprese militari di Alfonso, di contro all’opinione di autorevoli boiardisti, e in particolare di Antonia Tissoni Benvenuti e Cristina Montagnani, e in accordo invece con Tiziano Zanato

Ipotesi su Dino Frescobaldi lettore della 'Commedia'

L’articolo si sofferma inizialmente sulle differenti versioni del famoso racconto di Boccaccio sui sette canti dell’Inferno, con l’obiettivo di mettere in luce come elementi di realtà siano rielaborati e mescolati per accreditare l’ipotesi di una genesi fiorentina della Commedia. Successivamente viene esaminata la canzone di Dino Frescobaldi Voi che piangete nello stato amaro, confermando che il testo è influenzato dai primi canti dell’Inferno, ma che ne rovescia volutamente la situazione, rispondendo forse a un invio da parte di Dante stesso.The article deals with the different versions of Boccaccio’s famous tale of the seven cantos of the Inferno, with the aim of highlighting how elements of reality are rearranged and mixed in order to accredit the idea of a Florentine genesis of the Divine Comedy. Subsequently, the paper provides a new reading of Dino Frescobaldi’s canzone Voi che piangete nello stato amaro, confirming that the text is influenced by the first cantos of the Inferno, but that it deliberately reverses the situation, perhaps responding to Dante, who would have sent the first cantos to Florence

Introduzione

Introduzione al volume I "Sonetti et canzoni" di Iacopo Sannazaro (Gargnano del Garda 20-21 settembre 2018), a cura di Gabriele Baldassari e Michele Comelli, 202

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

Ellagic acid, a polyphenolic compound present in fruit and berries, has recently been the object of extensive research for its antioxidant activity, which might be useful for the prevention and treatment of cancer, cardiovascular pathologies, and neurodegenerative disorders. Its protective role justifies numerous attempts to include it in functional food preparations and in dietary supplements, and not only to limit the unpleasant collateral effects of chemotherapy. However, ellagic acid use as a chemopreventive agent has been debated because of its poor bioavailability associated with low solubility, limited permeability, first pass effect, and interindividual variability in gut microbial transformations. To overcome these drawbacks, various strategies for oral administration including solid dispersions, micro and nanoparticles, inclusion complexes, self-emulsifying systems, and polymorphs were proposed. Here, we listed an updated description of pursued micro and nanotechnological approaches focusing on the fabrication processes and the features of the obtained products, as well as on the positive results yielded by in vitro and in vivo studies in comparison to the raw material. The micro and nanosized formulations here described might be exploited for pharmaceutical delivery of this active, as well as for the production of nutritional supplements or for the enrichment of novel foods

A new microdispersed albumin derivative potentially useful for radio-guided surgery of occult breast cancer lesions

This paper describes a new nuclear imaging agent, 2-(4-isothiocyanatobenzyl) 121,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid of human albumin (HAC), potentially suitable for application in the Radio-guided Occult Lesion Localization (ROLL) of non-palpable mammalian cancerous lesions, as a tool to overtake the short radio-signal half-life of the technetium-99m based radiopharmaceutical currently used. This conjugate is a microsized powder aggregate, water-insoluble between pH 3 and 8.5, obtained by conjugating the protein with the macrocyclic chelating agent DOTA through a one-pot reaction in aqueous medium. The product has been fully characterized and is stable to the thermal conditions adopted for labeling; after radiolabeling with longer half-life radionuclides such as 177 Lu or 111 In, it has shown radiochemical purity (RCP) >90% and resulted stable when stored in saline or plasma for 6 days at 37 \ub0C. A \u3bcPET/CT study, performed in vivo on adult female rats, showed that the radioactivity of HAC labeled with 64 Cu remained located in the mammary glands for at least 40 h, without diffusion or drainage in healthy tissues or in the lymphatic circulation. This new imaging agent might make the ROLL procedure more accessible, safe and flexible, promoting a significant time and cost reduction of this intervention. Moreover, HAC might also be used in other radio-guided surgical procedures in oncology

Da Boiardo a Bembo. Saggi sulla lirica settentrionale nel Quattrocento

Il volume raccoglie 23 saggi di Tiziano Zanato dedicati alla lirica volgare quattrocentesca, da Boiardo a Bembo, rappresentando una riedizione, parzialmente aggiornata, di studi che si sviluppano nell'arco di un ventennio