Laboratory information management system study & development of LIMS web platform application for CTCV - Coimbra

The World Wide Web not only changes the process but also improves the user experience. Also, it dramatically changes how the computer software is built. This profound evolution of software development has caused developers in the software industry to change their way of developing software. In this project, the Laboratory Information Management System (LIMS) for Staff and Users of small business have been designed and developed using Throwaway Prototyping methodology with the web architecture. Different types of development platforms are available in the market to develop this application, but as per the company requirements, this application was developed with the .net framework. This web application allows us to access application data on different devices like a tablet, a desktop, a smartphone from the remote location all over the world. The main feature of this application offers to monitor the application activity like which activity was performed by the user with the corresponding date, time and short description. Therefore, this software uses an industry standard relational database management system (RDBMS) combined with a platform-independent web browser interface for data entry and the retrieval. (The 3-tier technology) The laboratory workflow steps facilitate the management and tracking of all test and test results, which ensures that the right information is available at the right time to a right person. This system will produce an efficient process in the laboratory which leads to faster work, fewer errors, and smoother workflow for an organization. Keywords IndustryN/

Rajonivruti (Menopause) - Ayurvedic point of view

Men and women reach old age with different prospects for older age. Aging is a real challenge for women. Life span of every individual is divided into three Avastha (stages) as Bala, Madhya and Vriddha in our classics. Kapha, Pitta and Vata Dosha dominate Bala, Madhya and Vriddhawastha respectively. This phase of life is more vulnerable for women, as along with aging, she suffers from inevitable scars of menopause. With increasing life expectancy, women spend one third of her lifetime under postmenopausal period. Menopause is a natural process in which menstruation definitively ceases, signalling the end of a woman’s reproductive life and it’s a natural process, not an illness, but a variety of disturbing symptoms can appear during this transition. Menopause usually occurs around the average age of 45. In women, reproductive period is controlled by Pitta Dosha. In Vriddhawastha, where Rajonivritti is a major event, Vata is the leading Dosha. In modern context, estrogen governs the reproductive period and its deficiency manifests as menopause. Hence, change in level of hormones marks puberty and menopause, where as in Ayurvedic classics change in status of Dosha and Dhatu marks onset of Raja and Rajonivritti. Rajonivritti is a marker of aging in women

Ethyl 2-[(Z)-3-chloro­benzyl­idene]-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-1,3-thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate

In the title compound, C23H19ClN2O3S, the central pyrimidine ring is significantly puckered, assuming almost a screw boat conformation. In addition to the usual inter­molecular C—H⋯O hydrogen bonding, short intra­molecular C—H⋯S contacts and π–π stacking inter­actions [centroid–centroid distance = 3.762 (2) Å] contribute to the crystal packing

Ethyl 2-(2-acetoxy­benzyl­idene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-1,3-thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate1

In the title mol­ecule, C25H22N2O5S, the atoms of the thia­zolopyrimidine ring system, with the exception of the phenyl-bearing C atom [deviation = 0.177 (2) Å], are essentially planar [r.m.s deviation = 0.100 (2) °] and the mean plane of these atoms forms dihedral angles of 89.86 (10) and 7.97 (8)° with the phenyl and benzene rings, respectively. In the crystal, co-operative C—H⋯O and C—H⋯π inter­actions lead to a supra­molecular chain along the a axis. These chains are connected via π–π inter­actions [centroid–centroid = 3.7523 (13) Å]

Ethyl (2Z)-2-(3-methoxy­benzyl­idene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-1,3-thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate

In the title compound, C24H22N2O4S, the central pyrimidine ring is significantly puckered, assuming a conformation inter­mediate between a boat and a screw boat. The nearly planar thia­zole ring (r.m.s. deviation = 0.0258 Å) is fused with the pyriamidine ring, making a dihedral angle of 9.83 (7)°. The carboxyl group is in an extended conformation with an anti-periplanar orientation with respect to the dihydropyrimidine ring. The benzene ring linked at the chiral C atom is perpendicular to the pyrimidine ring [dihedral angle = 85.21 (8)°] whereas the phenyl ring is nearly coplanar, making a dihedral angle of 13.20 (8)°. An intra­molecular C—H⋯S hydrogen bond is observed. The crystal packing is influenced by weak inter­molecular C—H⋯π inter­actions and π–π stacking between the thia­zole and phenyl rings [centroid–centroid distance = 3.9656 (10) Å], which stack the mol­ecules along the c axis

N-(2-Oxo-2H-chromen-3-yl)benzamide

The phenyl ring in title mol­ecule, C16H11NO3, forms a dihedral angle of 7.69 (6)° with the fused ring system. The observed conformation is stabilized by intra­molecular N—H⋯O and C—H⋯O inter­actions. In the crystal, supra­molecular chains are formed along the b axis which are mediated by π–π inter­actions [centroid–centroid distance = 3.614 (2) Å]

4-{[(4Z)-5-Oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-yl­idene]meth­yl}phenyl acetate

The title mol­ecule, C18H13NO4, shows a dihedral angle between the terminal acetyl group (r.m.s. deviation = 0.0081 Å) and remaining non-H atoms (r.m.s. = 0.0734 Å) of 53.45 (7)°. The configuration about the central olefinic bond is Z and overall the mol­ecule has a U-shaped conformation. Supra­molecular chains along the b-axis direction are found in the crystal structure. These are stabilized by (C=O)⋯π(ring centroid of the 1,3-oxazole ring) inter­actions [3.370 (2) Å]

A study of effect of intra umbilical oxytocin in active management of third stage of labour

Background: Postpartum haemorrhage is a single major and leading cause of maternal morbidity and mortality. PPH is the loss of more than 500 ml blood following vaginal delivery or 1000 ml blood following caesarean section. India has a maternal mortality ratio of 167 per 1 lakh live births. The most common cause of maternal mortality is haemorrhage which accounts for 25-30% of maternal mortality of which PPH is a significant cause. Methods: 200 patients were included in this prospective observational study and divided into two groups, group A, underwent only active management of third stage of labour and group B received intra umbilical oxytocin administration in addition to AMTSL. The maternal and neonatal outcome was observed between the two and the difference was noted. Results: Mean duration of third stage of labour of group A patients was 3.89±0.89 minutes and Mean blood loss was 386±85.30 ml and that of group B patients was 1.96±0.68 minutes and 235±72.99 ml respectively. These were found to be statistically significant among all the other parameters. Conclusions: The duration of third stage of labour and the amount of postpartum blood loss was significantly less when intra umbilical injection of oxytocin was used in addition to AMTSL. So, to conclude intra umbilical vein oxytocin injection should be used routinely in addition to AMTSL in order to prevent PPH

N-(3,4-Dichloro­phen­yl)-3-oxo­butanamide

In the title compound. C10H9Cl2NO2, the acetamide residue is twisted out of the phenyl ring plane by 25.40 (9)°. An intra­molecular C—H⋯O close contact is observed. The N atom of the butanamide unit forms an inter­molecular N—H⋯O hydrogen bond with the symmetry-related carbonyl O atom, inter­linking mol­ecules into a C(4) chain along [100]. Additional C—H⋯O inter­molecular inter­actions and Cl⋯Cl contacts [3.4364 (8) Å] contribute to the stability of the crystal packing