Meeting Minutes of the Committee in Detroit

Minutes of the committee in Detroit, which was organized to support Albertus C. Van Raalte and his people in making a settlement in Michigan. The meeting was held in the Presbyterian Church. Seven people were appointed to the committee: Theodore Romeyn, Shubael Conant, Rev. George Duffield, E. C. Seaman, A. S. Porter, E. P. Hastings, and J. W. Brooks. Other people in the state were designated to assist Van Raalte as needed such as Rev. O. P. Hoyt, the Hon. N. A. Balch, of the Senate, in Kalamazoo; George Young in Grand Rapids; Rev. Wm. M. Ferry and Henry Pennoyer in Grand Haven; and J. R. Kellogg and E. B. Bassett of Allegan and others. Rev. Van Raalte, in a most touching and impressive manner, expressed his gratitude for the sympathy and aid proffered to his countrymen, and his gratification at having advanced thus far in the preparatory steps for the settlement in a land where labor would meet with its reward, and civil and religious freedom be secure. S. Conant was chair of the meeting and N. A. Balch, secretary.https://digitalcommons.hope.edu/vrp_1840s/1116/thumbnail.jp

Laboratory observations of midwater spawning by Illex illecebrosus

Visual observations and video-tape records were made for the first time of mid-water spawning by Illex illecebrosus in the Aquatron Laboratory pool tank. Coupled with data on the density of egg masses, they allow some conclusions to be drawn concerning possible mid-water spawning sites in nature

Helicopter tail rotor thrust and main rotor wake coupling in crosswind flight

The tail rotor of a helicopter with a single main rotor configuration can experience a significant reduction in thrust when the aircraft operates in crosswind flight. Brown’s vorticity transport model has been used to simulate a main rotor and tail rotor system translating at a sideslip angle that causes the tail rotor to interact with the main rotor tip vortices as they propagate downstream at the lateral extremities of the wake. The tail rotor is shown to exhibit a distinct directionally dependent mode during which tail rotors that are configured so that the blades travel forward at the top of the disk develop less thrust than tail rotors with the reverse sense of rotation. The range of flight speeds over which this mode exists is shown to vary considerably with the vertical location of the tail rotor. At low flight speeds, the directionally dependent mode occurs because the tail rotor is immersed within not only the downwash from the main rotor but also the rotational flow associated with clusters of largely disorganized vorticity within the main rotor wake. At higher flight speeds, however, the tail rotor is immersed within a coherent supervortex that strongly influences the velocity field surrounding the tail rotor

Properties of IIlex illecebrosus Egg Masses Potentially Influencing larval Oceanographic Distribution

Visual observations and video-tape records of the spawning of captive IIlex illecebrosus show that this species can produce gelatinous egg masses 50 cm or larger in diameter while swimming in open water. Measurements of the density of the eggs and the changes in water density which are necessary to lift egg masses indicate that the masses have densities about 0.005% greater than the water used to make the gel, whereas the eggs are more than 5% denser than typical seawater. The gel thus appears to function as a buoyancy mechanism which prevents eggs from sinking. Measurements of rates of temperature equilibration between egg masses and the surrounding water indicate that complete density equilibration requires many days under most conditions. If spawning occurs pelagically, common oceanographic situations where density increases with depth, due either to decreasing temperature (e.g. North Atlantic Central Water) or increasing salinity (e.g. the Gulf Stream), could allow the egg masses to be suspended in the mesopelagic zone. Such a mechanism, which could retain pelagically-spawned eggs of IIlex and other oegopsids, particularly ommastrephids, in a zone where temperatures are adequate to allow embryonic development, helps to explain why there are so few records of ommastrephid eggs in nature

Thick primary melanoma has a heterogeneous tumor biology: an institutional series

<p>Abstract</p> <p>Background</p> <p>Thick melanomas (TM) ≥4 mm have a high risk for nodal and distant metastases. Optimal surgical management, prognostic significance of sentinel node biopsy (SLNB), and benefits of interferon (IFN) for these patients are unclear. As a continuum of increasing tumor thickness is placed into a single TM group, differences in biologic and clinical behavior may be lost. The purpose of this study was to better characterize the diverse biology in TM, including the value of increasing thickness and nodal status information, potentially identifying high risk TM subgroups that may warrant more aggressive treatment/follow up.</p> <p>Methods</p> <p>155 consecutive TM patients treated at a single institution between 1971 and 2007 were retrospectively reviewed. Patient, disease and treatment features were analyzed with respect to disease-free (DFS) and overall survival (OS).</p> <p>Results</p> <p>Median patient age was 66 years and 68% of patients were men. The trunk was the most common TM location (35%), followed by the head and neck (29%) and lower extremities (20%). Median thickness was 6 mm and 61% were ulcerated. 6% patients had stage IV disease, 12% had clinical nodal metastases. Clinically negative lymph node basins were treated by observation (22 patients - 15.4%), elective lymph node dissection (ELND) (24 patients - 17.6%) or SLNB (91 patients - 67%). 75% of ELND's and 53% of SLNB's were positive. Completion node dissection was performed in 38 SLNB+ patients and 22% had additional positive nodes. 17% of the study patients received IFN. At median follow up of 26 months, 5 year DFS and OS were 42% and 43.6%. For SLNB positive vs negative, median DFS were 22 vs 111 months (p = 0.006) and median OS were 41 vs 111 months (p = 0.006). When stratified by tumor thickness ≤ vs > 6 mm, 5 year DFS was 58.3% vs 20% (p < 0.0001) and OS was 62% vs 20% (P < 0.0001). IFN had no impact on DFS or OS (p = 0.98 and 0.8 respectively).</p> <p>Conclusion</p> <p>Within the high risk group of patients with TM, cases with tumor thickness > 6 mm or a positive SLNB had a significantly worse DFS and OS (p < .0001, <.0001 and .006, .006).</p

Primary cutaneous melanoma of the breast: A case report

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background: Primary cutaneous melanoma of the breast is a very rare tumour, accounting for &lt; 5 % of all malignant melanomas. Case presentation: A young lady was seen in the breast clinic for a skin lesion in the right breast. Clinical examination and investigations confirmed a diagnosis of a primary cutaneous melanoma of the breast. The lesion was excised and the patient made good recovery. She has shown no signs of local recurrence and is under regular follow-up in the dermatology clinic. Conclusion: This case is educational as it shows that the treatment of breast cutaneous melanoma is similar to that for any skin parts with surgery remaining the main therapeutic option. It also shows that mastectomy is unnecessary as it does not improve the results obtained by wide local excision of melanoma. Background Primary cutaneous melanoma rarely affects the breast, accounting for less than 5 % of all malignant melanomas

Prognosis of Sentinel Node Staged Patients with Primary Cutaneous Melanoma

Background: This study investigated survival probabilities and prognostic factors in sentinel lymph node biopsy (SLNB) staged patients with cutaneous melanoma (CM) with the aim of defining subgroups of patients who are at higher risk for recurrences and who should be considered for adjuvant clinical trials.\ud \ud Methods: Patients with primary CM who underwent SLNB in the Department of Dermatology, University of Tuebingen, Germany, between 1996 and 2009 were included into this study. Survival probabilities and prognostic factors were evaluated by Kaplan-Meier and multivariate Cox proportional hazard models.\ud \ud Results: 1909 SLNB staged patients were evaluated. Median follow-up time was 44 months. Median tumor thickness was 1.8 mm, ulceration was present in 31.8% of cases. The 5-year Overall Survival (OS) was 90.3% in SLNB negative patients (IB 96.2%, IIA 87.0%, IIB 78.1%, IIC 72.6%). Patients with micrometastases (stage IIIA/B) had a 5-year OS rate of 70.9% which was clearly less favorable than for stages I–II. Multivariate analysis revealed tumor thickness, ulceration, body site, histopathologic subtype and SLNB status as independent significant prognostic factors.\ud \ud Conclusion: Survival rates of patients with primary CM in stages I–II were shown to be much more favorable than previously reported from non sentinel node staged collectives. For future clinical trials, sample size calculations should be adapted using survival probabilities based on sentinel node staging

Segmentation of Skin Lesions Using Level Set Method

Diagnosis of skin cancers with dermoscopy has been widely accepted as a clinical routine. However, the diagnostic accuracy using dermoscopy relies on the subjective judgment of the dermatologist. To solve this problem, a computer-aided diagnosis system is demanded. Here, we propose a level set method to fulfill the segmentation of skin lesions presented in dermoscopic images. The differences between normal skin and skin lesions in the color channels are combined to define the speed function, with which the evolving curve can be guided to reach the boundary of skin lesions. The proposed algorithm is robust against the influences of noise, hair, and skin textures, and provides a flexible way for segmentation. Numerical experiments demonstrated the effectiveness of the novel algorithm