Dating the Media:Participation, Voice, and Ritual Logic in the Disability Dating Show The Undateables

Interventional television formats centering around the ritual transformation of “ordinary people” are not only followed by sizable audiences worldwide but also attract large numbers of aspiring candidates. Although the benefits and consequences of participating in such shows have long been debated within academia and beyond, research into actual experiences of participating in such television productions remains scarce. Based on in-depth interviews with participants of the disability dating show The Undateables, this article focuses on how contributors deal with their position in the production and how their experiences reflect the emancipatory claims of the program. By presenting the production process through the story and from the perspective of three participants, different modes of participation will be discussed, revealing how instances of submission, appropriation, and contestation of the production logic are linked to ideals of representation, notions about empowerment and voice, and to strategies of negotiating normalcy and difference.</p

Dating the Media:Participation, Voice, and Ritual Logic in the Disability Dating Show The Undateables

Interventional television formats centering around the ritual transformation of “ordinary people” are not only followed by sizable audiences worldwide but also attract large numbers of aspiring candidates. Although the benefits and consequences of participating in such shows have long been debated within academia and beyond, research into actual experiences of participating in such television productions remains scarce. Based on in-depth interviews with participants of the disability dating show The Undateables, this article focuses on how contributors deal with their position in the production and how their experiences reflect the emancipatory claims of the program. By presenting the production process through the story and from the perspective of three participants, different modes of participation will be discussed, revealing how instances of submission, appropriation, and contestation of the production logic are linked to ideals of representation, notions about empowerment and voice, and to strategies of negotiating normalcy and difference.</p

No Evidence That Protein Noise-Induced Epigenetic Epistasis Constrains Gene Expression Evolution

Changes in gene expression can affect phenotypes and therefore both its level and stochastic variability are frequently under selection. It has recently been proposed that epistatic interactions influence gene expression evolution: gene pairs where simultaneous knockout is more deleterious than expected should evolve reduced expression noise to avoid concurrent low expression of both proteins. In apparent support, yeast genes with many epistatic partners have low expression variation both among isogenic individuals and between species. However, the specific predictions and basic assumptions of this verbal model remain untested. Using bioinformatics analysis, we first demonstrate that the model's predictions are unsupported by available large-scale data. Based on quantitative biochemical modeling, we then show that epistasis between expression reductions (epigenetic epistasis) is not expected to aggravate the fitness cost of stochastic expression, which is in sharp contrast to the verbal argument. This nonintuitive result can be readily explained by the typical diminishing return of fitness on gene activity and by the fact that expression noise not only decreases but also increases the abundance of proteins. Overall, we conclude that stochastic variation in epistatic partners is unlikely to drive noise minimization or constrain gene expression divergence on a genomic scale

Dating the Media: Participation, Voice, and Ritual Logic in the Disability Dating Show The Undateables

Interventional television formats centering around the ritual transformation of “ordinary people” are not only followed by sizable audiences worldwide but also attract large numbers of aspiring candidates. Although the benefits and consequences of participating in such shows have long been debated within academia and beyond, research into actual experiences of participating in such television productions remains scarce. Based on in-depth interviews with participants of the disability dating show The Undateables, this article focuses on how contributors deal with their position in the production and how their experiences reflect the emancipatory claims of the program. By presenting the production process through the story and from the perspective of three participants, different modes of participation will be discussed, revealing how instances of submission, appropriation, and contestation of the production logic are linked to ideals of representation, notions about empowerment and voice, and to strategies of negotiating normalcy and difference

‘These cameras are here for a reason’- media coming out, symbolic power and the value of ‘participation'

This article addresses the increasing popularity of coming out as mediatized practice, by focusing on the example of the internationally successful Dutch television programme Uit de Kast (‘Out of the Closet’). While the choice of coming out in front of the cameras is often received controversially both by the public and the protagonists’ immediate environment, youngsters keep applying to participate in the programme. To understand the continuous appeal of this form of self-disclosure, in-depth interviews were conducted with 10 participants from different seasons about their motivations, experiences and evaluations of ta

The Genomic Landscape of Compensatory Evolution

Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes. This process can potentially influence directions of adaptive evolution by enabling evolutionary routes that are otherwise inaccessible. Therefore, the extent to which compensatory mutations shape genomic evolution is of central importance. Here, we studied the capacity of the baker's yeast genome to compensate the complete loss of genes during evolution, and explored the long-term consequences of this process. We initiated laboratory evolutionary experiments with over 180 haploid baker's yeast genotypes, all of which initially displayed slow growth owing to the deletion of a single gene. Compensatory evolution following gene loss was rapid and pervasive: 68% of the genotypes reached near wild-type fitness through accumulation of adaptive mutations elsewhere in the genome. As compensatory mutations have associated fitness costs, genotypes with especially low fitnesses were more likely to be subjects of compensatory evolution. Genomic analysis revealed that as compensatory mutations were generally specific to the functional defect incurred, convergent evolution at the molecular level was extremely rare. Moreover, the majority of the gene expression changes due to gene deletion remained unrestored. Accordingly, compensatory evolution promoted genomic divergence of parallel evolving populations. However, these different evolutionary outcomes are not phenotypically equivalent, as they generated diverse growth phenotypes across environments. Taken together, these results indicate that gene loss initiates adaptive genomic changes that rapidly restores fitness, but this process has substantial pleiotropic effects on cellular physiology and evolvability upon environmental change. Our work also implies that gene content variation across species could be partly due to the action of compensatory evolution rather than the passive loss of genes

Orvostanhallgatók mentális egészségfejlesztése

Balázs Bianka, Boross Katalin, Debreceni Dorottya, Nagy Boglárka, Petes Cintia, Rajhóczki Álmos Péte

Sources of variation in haematocrit in the Collared Flycatcher (Ficedula albicollis)

The haematocrit rate of the blood shows the individual physiological state. As the haematocrit grows, the higher erythrocyte number results in more efficient oxygen uptake capacity which can lead to better performance and probably a better survival rate of an individual. Hence we assume that the high value of haematocrit reflects good health state. Altogether 308 blood samples were collected from a wild population of Collared Flycatchers (Ficedula albicollis) in two breeding stages during a period of 2008–2010. We tried to elucidate the relationship between condition and haematocrit level of an individual and studied the haematocrit changes of an individual between years. The haematocrit values differed between years. Females had higher haematocrit values than males in 2010 but not in 2009. At courtship the haematocrit level of males was higher, than during nestling care. The different environmental effects and energy demands of the individuals may be the driving force behind the observed changes in haematocrit level. Analysing the changes between two years, there was a positive correlation between changes in condition index and haematocrit of individuals. The haematocrit values of an individual were repeatable between years. This finding suggests that haematocrit can be informative about the individual’s general health state