Osteomyelitis of the mandible in the patient with plasmocytoma – case report

Osteomyelitis is an infection of bone which may be caused by infection carried to the bone via the bloodstream or from surrounding tissue. Treatment of osteomyelitis of the mandible is extremely difficult because of oral environment and teeth presence. Management often involves both debridement and antibiotic selection. Despite this, aggressive surgical interventions and conservative therapy are most important aspects of treatment.Medication-related osteonecrosis of the jaw (MRONJ) is an avascular necrosis related to osteomyelitis and characterized by necrotic bone in the maxillofacial region. The prevalence of this is associated with treatment with high-potency bisphosphonates or denosumab and it seems to be getting increasingly frequent. Due to lack of prospective studies with long-term follow-up there are no recommendation for treatment of MRNOJ. The main aim of treatment of patients with MRNOJ is to continue and to support oncological treatment as well as to provide patient education, comfort to life, control of pain and to prevent from secondary infection and development of new areas of necrosis

Non symptomatic atrial septal defect venosus type IVC – SV coexistent with non-obstructed foramen ovale in 78 years old patient – a case report

Topyła Weronika Sandra, Krasuska Beata, Bal Wioletta Anna, Bąk Tomasz Krzysztof, Staciwa Agnieszka Zofia. Non symptomatic atrial septal defect venosus type IVC – SV coexistent with non-obstructed foramen ovale in 78 years old patient – a case report. Journal of Education, Health and Sport. 2017;7(12):40-44. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1095604 http://ojs.ukw.edu.pl/index.php/johs/article/view/5098 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.11.2017. Revised: 15.11.2017. Accepted: 09.12.2017. Non symptomatic atrial septal defect venosus type IVC – SV coexistent with non-obstructed foramen ovale in 78 years old patient – a case report Weronika Sandra Topyła http://orcid.org/0000-0002-3997-9952 https://orcid.org/0000-0002-3997-9952 Medical University of Lublin Poland Beata Krasuska http://orcid.org/0000-0001-8010-1642 https://orcid.org/0000-0001-8010-1642 Medical University of Lublin Poland Wioletta Anna Bal http://orcid.org/0000-0003-4992-5322 https://orcid.org/0000-0003-4992-5322 Medical University of Lublin Poland Tomasz Krzysztof Bąk http://orcid.org/0000-0002-6062-0848 https://orcid.org/0000-0002-6062-0848 Medical University of Lublin Poland Agnieszka Zofia Staciwa http://orcid.org/0000-0003-4784-4772 https://orcid.org/0000-0003-4784-4772 Medical University of Lublin Poland ABSTRACT Atrial septal defect may be seen under few forms. The most common is ASD secundarum – about 70% of defects. Coexistent non-obstructed foramen ovale with atrial septal defect venosus type IVC – SV is very rare. Untreated atrial septal defect can be associated with numerous complications and with significantly shortened life expectancy. Patients with the increased left-to-right shunting may occasionally present congestive heart failure with pulmonary hypertension in their fourth to sixth decades of life. Late problems in untreated patients also include the risk of paradoxical embolus as well as atrial fibrillation, pulmonary hypertension and right heart failure. The presented medical case is an example of a very rare clinical disease in which a complex heart defect within the atrial septum is asymptomatic, does not give any complications and does not require treatment

Echocardiographic assessment of mediastinal tumor - a case report

The mediastinum is the central area of the thoracic cavity which is divided into anterior, middle and posterior section. Medisatinal masses are usually asymptomatic. They can be detected accidentally in planned imaging studies. Echocardiography is safe, cheap, quick and non-invasive investigation, which can be useful in the diagnosis of this type of changes

Tracheal stenosis as a late complication of cardiac arrest- a case report

A sudden cardiac arrest (SCA) and cardiopulmonary resuscitation (CPR) could be associated with numerous acute complications, including rib fractures, sternal fractures, bleeding in the anterior mediastinum. Some of late complications are associated with mechanical ventilation. They include: stenosis, tracheomalacia or tracheoinnominate-artery fistula. These complications can be subclinical or may present as failure to wean from the ventilator, failure to decannulate, or may manifest as upper-airway obstruction with respiratory failure

First familial cases of type 2 congenital erythrocytosis (ECYT2) with a Chuvash pathogenic variant in gene in Poland: example of the clinical utility of next-generation sequencing in diagnostics of orphan diseases

In this article, we report familial cases of type 2 congenital erythrocytosis (ECYT2) in two siblings, a 2-year-old boy and his younger sister. Both patients were diagnosed based on laboratory findings including erythrocytosis, elevated hemoglobin levels, and hematocrit. Acquired erythrocytosis was excluded based on the clinical features and genetic analysis of genes. Next-generation sequencing was employed for older brother revealing NM_000551.4: c.598C>T, p.Arg200Trp homozygous variant in the gene, the similar variant was detected in the younger sibling. Sequencing analysis confirmed the c.598C>T heterozygous variant in both parents. To the best of our knowledge, these are the first confirmed cases of familial erythrocytosis type 2, also known as Chuvash type, in Poland

Late cardiac tamponade after pacemaker implantation in patient with third degree atrio-ventricular block - a case report

Patients suffering from third degree atrio-ventricular block need emergency treatment. Permanent cardiac pacing is the therapy of choice in third degree atrio-ventricular block. The incidence of complications following pacemaker implantation is low. The treatment is relatively safe. We present a case, which is an example of a very rare complication of cardiac pacing

Total 36 tooth reinclusion in a 7-year old patient

The phenomenon of permanent teeth reinclusion is an extremely rare occurrence both in clinical cases of patients and in literature descriptions. Untreated process may lead to many pathological consequences, such as: formation of abscesses, fistulas or, as in the case of the patient described, perforation of the buccal’s bone plate covering the 36 tooth. The article describes a very rare case of complete reinclusion of tooth 36 in a 7-year-old patient. Taking into account the risk of surgical complications, it was decided to perform the procedure in a hospital’s conditions

COVID-19 in pediatric cancer patients is associated with treatment interruptions but not with short-term mortality : a Polish national study

Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently constitutes the leading and overwhelming health issue worldwide. In comparison with adults, children present milder symptoms, with most having an asymptomatic course. We hypothesized that COVID-19 infection has a negative impact on the continuation of chemotherapy and increases nonrelapse mortality. Material and methods This study was performed to assess the course of SARS-CoV-2 among children with hematological or oncological malignancies and its impact on cancer therapy. Records of SARS-CoV-2 infection in 155 children with malignancies from 14 Polish centers for pediatric hematology and oncology were collected and analyzed. Results SARS-CoV-2 replication was observed in 155 patients. Forty-nine patients were symptomatic, with the following being the most common manifestations: fever (31 patients), gastrointestinal symptoms (10), coryza (13), cough (13) and headache (8). In children who were retested, the median time of a positive PCR result was 16 days (range 1–70 days), but 12.7% of patients were positive beyond day + 20. The length of viral PCR positivity correlated with the absolute neutrophil count at diagnosis. Seventy-six patients did not undergo further SARS-CoV-2 testing and were considered convalescents after completion of isolation. Antibiotic therapy was administered in 15 children, remdesivir in 6, convalescent plasma in 4, oxygen therapy in 3 (1—mechanical ventilation), steroids in 2, intravenous immunoglobulins in 2, and heparin in 4. Eighty patients were treated with chemotherapy within 30 days after SARS-CoV-2 infection diagnosis or were diagnosed with SARS-CoV-2 infection during 30 days of chemotherapy administration. Respiratory symptoms associated with COVID-19 and associated with oxygen therapy were present in 4 patients in the study population, and four deaths were recorded (2 due to COVID-19 and 2 due to progressive malignancy). The probability of 100-day overall survival was 97.3% (95% CI 92.9–99%). Delay in the next chemotherapy cycle occurred in 91 of 156 cases, with a median of 14 days (range 2–105 days). Conclusions For the majority of pediatric cancer patients, SARS-CoV-2 infection does not result in a severe, life-threatening course. Our data show that interruptions in therapy are common and can result in suboptimal therapy