Psychogenic non epileptic seizures : towards an integration of psychogenic, cognitive and neurobiological aspects

Psychogenic Non Epileptic Seizures (PNES) are defined as paroxysmal involuntary behavioral patterns that mimic epileptic events –covering the full range of hypo-motor events to hyper-motor manifestations– but that lack ictal epileptiform activity in the brain. PNES cannot be fully explained by any known neurological or other somatic diseases and are thought to be mediated by psychological factors (WHO, 1993; APA, 1994). PNES are characterized by a sudden and time-limited alteration of consciousness and are associated with a disturbance in controlling cognitive, behavioral and/or emotional functions (Kuyk et al., 1999)LEI Universiteit LeidenFSW - Self-regulation models for health behavior and psychopathology - ou

Basal cortisol is positively correlated to threat vigilance in patients with

Wetensch. publ. refereedFaculteit der Sociale Wetenschappe

Basal cortisol is positively correlated to threat vigilance in patients with psychogenic nonepileptic seizures.

FSW - Self-regulation models for health behavior and Psychopathology - Ou

Trauma, stress, and preconscious threat processing in patients with psychogenic nonepileptic seizures.

FSW - Self-regulation models for health behavior and Psychopathology - Ou

The effects of social stress and cortisol responses on the preconscious selective attention to social threat.

CKC

Instances and connectors : issues for a second generation process language

This work is supported by UK EPSRC grants GR/L34433 and GR/L32699Over the past decade a variety of process languages have been defined, used and evaluated. It is now possible to consider second generation languages based on this experience. Rather than develop a second generation wish list this position paper explores two issues: instances and connectors. Instances relate to the relationship between a process model as a description and the, possibly multiple, enacting instances which are created from it. Connectors refers to the issue of concurrency control and achieving a higher level of abstraction in how parts of a model interact. We believe that these issues are key to developing systems which can effectively support business processes, and that they have not received sufficient attention within the process modelling community. Through exploring these issues we also illustrate our approach to designing a second generation process language.Postprin

Re-visiting Meltsner: Policy Advice Systems and the Multi-Dimensional Nature of Professional Policy Analysis

10.2139/ssrn.15462511-2

The STRESS-NL database: A resource for human acute stress studies across the Netherlands

Stress initiates a cascade of (neuro)biological, physiological, and behavioral changes, allowing us to respond to a challenging environment. The human response to acute stress can be studied in detail in controlled settings, usually in a laboratory environment. To this end, many studies employ acute stress paradigms to probe stress-related outcomes in healthy and patient populations. Though valuable, these studies in themselves often have relatively limited sample sizes. We established a data-sharing and collaborative interdisciplinary initiative, the STRESS-NL database, which combines (neuro)biological, physiological, and behavioral data across many acute stress studies in order to accelerate our understanding of the human acute stress response in health and disease (www.stressdatabase.eu). Researchers in the stress field from 12 Dutch research groups of 6 Dutch universities created a database to achieve an accurate inventory of (neuro)biological, physiological, and behavioral data from laboratory-based human studies that used acute stress tests. Currently, the STRESS-NL database consists of information on 5529 individual participants (2281 females and 3348 males, age range 6-99 years, mean age 27.7 ± 16 years) stemming from 57 experiments described in 42 independent studies. Studies often did not use the same stress paradigm; outcomes were different and measured at different time points. All studies currently included in the database assessed cortisol levels before, during and after experimental stress, but cortisol measurement will not be a strict requirement for future study inclusion. Here, we report on the creation of the STRESS-NL database and infrastructure to illustrate the potential of accumulating and combining existing data to allow meta-analytical, proof-of-principle analyses. The STRESS-NL database creates a framework that enables human stress research to take new avenues in explorative and hypothesis-driven data analyses with high statistical power. Future steps could be to incorporate new studies beyond the borders of the Netherlands; or build similar databases for experimental stress studies in rodents. In our view, there are major scientific benefits in initiating and maintaining such international efforts