Discrimination of prostate cancer cells and non-malignant cells using secondary ion mass spectrometry

This communication utilises Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) combined with multivariate analysis to obtain spectra from the surfaces of three closely related cell lines allowing their discrimination based upon mass spectral ions

Homeless People Need Stable Employment and Coordinated Services to Climb Out of Poverty

Before any successful employment, the homeless need stable and secure housing. Employment programs for the homeless should be designed to help with all of the barriers that homeless people face in getting a stable job. The focus needs to be on securing long-term employment for the homeless instead of short-term jobs. Education and skills training is crucial to getting long-term well paying employment with benefits.York's Knowledge Mobilization Unit provides services and funding for faculty, graduate students, and community organizations seeking to maximize the impact of academic research and expertise on public policy, social programming, and professional practice. It is supported by SSHRC and CIHR grants, and by the Office of the Vice-President Research & Innovation. [email protected] www.researchimpact.c

Dielectric Resonator Method for Measuring the Electrical Conductivity of Carbon Nanotubes from Microwave to Millimeter Frequencies

We describe a dielectric resonator-based measurement method for determining the electrical conductivity of carbon nanotubes at microwave to millimeter frequencies. This measurement method is not limited by the metal conductor contact resistances or impedance mismatch commonly encountered in the measurement of single nanotubes. The measurement of carbon nanotubes yielded conductivities of approximately 0.08×107 S/m

RNAi-induced silencing of embryonic tryptophan oxygenase in the Pyralid moth, Plodia interpunctella

Gene silencing through the introduction of double-stranded RNA (RNA interference, RNAi) provides a powerful tool for the elucidation of gene function in many systems, including those where genomics and proteomics are incomplete. The use of RNAi technology for gene silencing in Lepidoptera has lacked significant attention compared to other systems. To demonstrate that RNAi can be utilized in the lepidopteran, Plodia interpunctella, we cloned a cDNA for tryptophan oxygenase, and showed that silencing of tryptophan oxygenase through RNAi during embryonic development resulted in loss of eye-color pigmentation. The complete amino acid sequence of Plodia tryptophan oxygenase can be accessed through NCBI Protein Database under NCBI Accession # AY427951. Abbreviation / RNAi: RNA interference PCR: polymerase chain reaction RT-PCR: reverse transcription-PC

Binary black hole merger dynamics and waveforms

We study dynamics and radiation generation in the last few orbits and merger of a binary black hole system, applying recently developed techniques for simulations of moving black holes. Our analysis of the gravitational radiation waveforms and dynamical black hole trajectories produces a consistent picture for a set of simulations with black holes beginning on circular-orbit trajectories at a variety of initial separations. We find profound agreement at the level of one percent among the simulations for the last orbit, merger and ringdown. We are confident that this part of our waveform result accurately represents the predictions from Einstein's General Relativity for the final burst of gravitational radiation resulting from the merger of an astrophysical system of equal-mass non-spinning black holes. The simulations result in a final black hole with spin parameter a/m=0.69. We also find good agreement at a level of roughly 10 percent for the radiation generated in the preceding few orbits.Comment: 11 pages, 11 figures, submitted to PRD, update citations, minor change

The Impact of Taxation on the Development of Geothermal Resources

This contractor report reviews past and current tax mechanisms for the development and operation of geothermal power facilities. A 50 MW binary plant is featured as the case study. The report demonstrates that tax credits with windows of availability of greater than one year are essential to allow enough time for siting and design of geothermal power systems. (DJE 2005

Binary black hole late inspiral: Simulations for gravitational wave observations

Coalescing binary black hole mergers are expected to be the strongest gravitational wave sources for ground-based interferometers, such as the LIGO, VIRGO, and GEO600, as well as the space-based interferometer LISA. Until recently it has been impossible to reliably derive the predictions of General Relativity for the final merger stage, which takes place in the strong-field regime. Recent progress in numerical relativity simulations is, however, revolutionizing our understanding of these systems. We examine here the specific case of merging equal-mass Schwarzschild black holes in detail, presenting new simulations in which the black holes start in the late inspiral stage on orbits with very low eccentricity and evolve for ~1200M through ~7 orbits before merging. We study the accuracy and consistency of our simulations and the resulting gravitational waveforms, which encompass ~14 cycles before merger, and highlight the importance of using frequency (rather than time) to set the physical reference when comparing models. Matching our results to PN calculations for the earlier parts of the inspiral provides a combined waveform with less than half a cycle of accumulated phase error through the entire coalescence. Using this waveform, we calculate signal-to-noise ratios (SNRs) for iLIGO, adLIGO, and LISA, highlighting the contributions from the late-inspiral and merger-ringdown parts of the waveform which can now be simulated numerically. Contour plots of SNR as a function of z and M show that adLIGO can achieve SNR >~ 10 for some intermediate-mass binary black holes (IMBBHs) out to z ~ 1, and that LISA can see massive binary black holes (MBBHs) in the range 3x10^4 100 out to the earliest epochs of structure formation at z > 15.Comment: 17 pages, 20 figures. Final published versio