Extrapulmonary Tuberculosis among Somalis in Minnesota1

To analyze extrapulmonary tuberculosis in Somalis living in Minnesota, we reviewed surveillance and public health case management data on tuberculosis cases in ethnic Somalis in Minnesota from 1993 through 2003. The presence of these recent immigrants substantially affects the local epidemiology and clinical manifestation of tuberculosis

Knowledge Elicitation Methods for Affect Modelling in Education

Research on the relationship between affect and cognition in Artificial Intelligence in Education (AIEd) brings an important dimension to our understanding of how learning occurs and how it can be facilitated. Emotions are crucial to learning, but their nature, the conditions under which they occur, and their exact impact on learning for different learners in diverse contexts still needs to be mapped out. The study of affect during learning can be challenging, because emotions are subjective, fleeting phenomena that are often difficult for learners to report accurately and for observers to perceive reliably. Context forms an integral part of learners’ affect and the study thereof. This review provides a synthesis of the current knowledge elicitation methods that are used to aid the study of learners’ affect and to inform the design of intelligent technologies for learning. Advantages and disadvantages of the specific methods are discussed along with their respective potential for enhancing research in this area, and issues related to the interpretation of data that emerges as the result of their use. References to related research are also provided together with illustrative examples of where the individual methods have been used in the past. Therefore, this review is intended as a resource for methodological decision making for those who want to study emotions and their antecedents in AIEd contexts, i.e. where the aim is to inform the design and implementation of an intelligent learning environment or to evaluate its use and educational efficacy

The Structure of the Emotional Processing Scale (EPS-25): An Exploratory Structural Equation Modeling Analysis Using Medical and Community Samples

The Emotional Processing Scale (EPS) assesses emotional processing in terms of suppression, signs of unprocessed emotion, controllability of emotions, avoidance of emotional triggers, and impoverished emotional experience. Previous confirmatory factor analyses (CFA) yielded insufficient fit and questioned the EPS factors' discriminant validity. The present study aimed to test unidimensional, five-factor, and bifactor models using exploratory structural equation modeling (ESEM) and CFA. We administered the scale to 350 Italian participants in good health and 346 gastrointestinal patients referred for endoscopy because of mild-to-severe gastrointestinal symptoms. ESEM models outperformed corresponding CFA models. The bifactor ESEM model was a good fit in single group analyses and achieved metric and scalar invariance in multigroup analyses. The inspection of latent mean differences revealed a consistent trend for patients to avoid emotional triggers and have less general emotional processing difficulties. The study clarified the EPS factor structure and supported its use to assess the emotional processing of medical patients and community participants

El Astrologo Que Cayo En Un Pozo (The Astrologer Who Fell into a Well)

This book was completed for Jan Baker\u27s artists\u27 book class, Printed Books.https://digitalcommons.risd.edu/specialcollections_bookmark_senses/1002/thumbnail.jp

Molecular line emission in NGC 1068 imaged with ALMA: I. An AGN-driven outflow in the dense molecular gas

Based on observations carried out with ALMA in Cycle 0.-- et al.[Aims]: We investigate the fueling and the feedback of star formation and nuclear activity in NGC 1068, a nearby (D = 14 Mpc) Seyfert 2 barred galaxy, by analyzing the distribution and kinematics of the molecular gas in the disk. We aim to understand if and how gas accretion can self-regulate. [Methods]: We have used the Atacama Large Millimeter Array (ALMA) to map the emission of a set of dense molecular gas (n(H2) ' 1056 cm3) tracers (CO(3-2), CO(6-5), HCN(4-3), HCO+(4-3), and CS(7-6)) and their underlying continuum emission in the central r ∼ 2 kpc of NGC 1068 with spatial resolutions ∼0:3000:500 (∼20-35 pc for the assumed distance of D = 14 Mpc). [Results]: The sensitivity and spatial resolution of ALMA give an unprecedented detailed view of the distribution and kinematics of the dense molecular gas (n(H2) ≈ 1056cm3) in NGC 1068. Molecular line and dust continuum emissions are detected from a r ∼ 200 pc off-centered circumnuclear disk (CND), from the 2.6 kpc-diameter bar region, and from the r ∼ 1:3 kpc starburst (SB) ring. Most of the emission in HCO+, HCN, and CS stems from the CND. Molecular line ratios show dramatic order-of-magnitude changes inside the CND that are correlated with the UV/X-ray illumination by the active galactic nucleus (AGN), betraying ongoing feedback. We used the dust continuum fluxes measured by ALMA together with NIR/MIR data to constrain the properties of the putative torus using CLUMPY models and found a torus radius of 20+6 10 pc. The Fourier decomposition of the gas velocity field indicates that rotation is perturbed by an inward radial flow in the SB ring and the bar region. However, the gas kinematics from r ∼ 50 pc out to r ∼ 400 pc reveal a massive (Mmol ∼ 2:7+0:9 1:2 × 107 M) outflow in all molecular tracers. The tight correlation between the ionized gas outflow, the radio jet, and the occurrence of outward motions in the disk suggests that the outflow is AGN driven. [Conclusions]: The molecular outflow is likely launched when the ionization cone of the narrow line region sweeps the nuclear disk. The outflow rate estimated in the CND, dM=dt ∼ 63+21 37 M yr1, is an order of magnitude higher than the star formation rate at these radii, confirming that the outflow is AGN driven. The power of the AGN is able to account for the estimated momentum and kinetic luminosity of the outflow. The CND mass load rate of the CND outflow implies a very short gas depletion timescale of ≤1 Myr. The CND gas reservoir is likely replenished on longer timescales by efficient gas inflow from the outer disk. © ESO 2014.S.G.B. and I.M. acknowledge support from Spanish grants AYA2010-15169 and from the Junta de Andalucia through TIC-114 and the Excellence Project P08-TIC-03531. S.G.B., A.L., and A.F. acknowledge support from MICIN within program CONSOLIDER INGENIO 2010, under grant “Molecular Astrophysics: The Herschel and ALMA Era–ASTROMOL” (ref CSD2009-00038). S.G.B., A.U., L.C., and P.P. acknowledge support from Spanish grant AYA2012-32295. FC acknowledges the European Research Council for the Advanced Grant Program Num. 267399-Momentum. A.A.H. acknowledges support from the Universidad de Cantabria through the Augusto G. Linares programme and from the Spanish Plan Nacional grants AYA2009-05705-E and AYA2012-31447. C.R.A. is supported by a Marie Curie Intra European Fellowship within the 7th European Community Framework Programme (PIEF-GA-2012-327934). C.R.A. also ackowledges financial support from the Spanish Ministry of Science and Innovation (MICINN) through project PN AYA2010-21887-C04.04 (Estallidos).Peer Reviewe

Crianças Amazônidas no Círio de Nazaré: culturas e saberes outros

Amazonian children on Círio de Nazaré: others cultures and knowledgeResumoEste estudo fez uma análise das vivências de um grupo de onze criancas amazônidas, participantes do Projeto intitulado Caminhos do Círio,  no contexto do Círio de Nazaré, festa religiosa que entrelaça diferentes culturas e saberes, em que as crianças intérpretes da pesquisa vivenciam práticas educativas assentadas na cultura em que estão inseridas. Esse estudo teve como objetivo analisar e desvelar os saberes e os processos educativos vivenciados por essas crianças através de suas narrativas e percepções por meio de suas subjetividade e interações sociais. A partir deste estudo, identificou-se saberes religiosos, históricos, econômicos e lúdicos que as crianças amazônidas ao se relacionarem com seus familiares e com seus pares, partilham, transmitem e produzem, protagonizando sua história e sua cultura.Palavras-Chave: Criança; Círio de Nazaré; Cultura e Saberes. AbstractThis study made an analysis of experiences from a eleven amazonian children group, which are participants in the Project entitled Ways of Círio, in the Círio de Nazaré contexto, religious festival that interlace different cultures and knowlegde, whereby the children who are research interpreters, experience educative practices settled on culture which are inserted. This study had as objective analyse and exhibit the knowlegde and education processes experienced by these children through their narratives and perceptions by means of their subjectivities and social interactions. From this study, were identified religious, historical, economic and ludic knowledge that amazonian children, when dealing with their Family and pairs, share, transmit and and produce, featuring their history and culture.Key-words: Child. Círio de Nazaré. Culture and Knowledge.

Comparative clinical outcomes between direct oral anticoagulants and warfarin among elderly patients with non-valvular atrial fibrillation in the CMS medicare population

Atrial fibrillation (AF) prevalence increases with age; \u3e 80% of US adults with AF are aged ≥ 65 years. Compare the risk of stroke/systemic embolism (SE), major bleeding (MB), net clinical outcome (NCO), and major adverse cardiac events (MACE) among elderly non-valvular AF (NVAF) Medicare patients prescribed direct oral anticoagulants (DOACs) vs warfarin. NVAF patients aged ≥ 65 years who initiated DOACs (apixaban, dabigatran, and rivaroxaban) or warfarin were selected from 01JAN2013-31DEC2015 in CMS Medicare data. Propensity score matching was used to balance DOAC and warfarin cohorts. Cox proportional hazards models estimated the risk of stroke/SE, MB, NCO, and MACE. 37,525 apixaban– warfarin, 18,131 dabigatran–warfarin, and 55,359 rivaroxaban–warfarin pairs were included. Compared to warfarin, apixaban (HR: 0.69; 95% CI 0.59–0.81) and rivaroxaban (HR: 0.82; 95% CI 0.73–0.91) had lower risk of stroke/SE, and dabigatran (HR: 0.88; 95% CI 0.72–1.07) had similar risk of stroke/SE. Apixaban (MB: HR: 0.61; 95% CI 0.57–0.67; NCO: HR: 0.64; 95% CI 0.60–0.69) and dabigatran (MB: HR: 0.79; 95% CI 0.71–0.89; NCO: HR: 0.84; 95% CI 0.76–0.93) had lower risk of MB and NCO, and rivaroxaban had higher risk of MB (HR: 1.08; 95% CI 1.02–1.14) and similar risk of NCO (HR: 1.04; 95% CI 0.99–1.09). Compared to warfarin, apixaban had a lower risk for stroke/SE, MB, and NCO; dabigatran had a lower risk of MB and NCO; and rivaroxaban had a lower risk of stroke/SE but higher risk of MB. All DOACs had lower risk of MACE compared to warfarin

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.

For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types. Recently, it has been recognized that embryonic stem cells derived from both mice and humans exhibit two stable yet epigenetically distinct states of pluripotency: naive and primed. We now show that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in human embryonic stem cells (hESCs).  Specifically, in naive hESCs, NNMT and its enzymatic product 1-methylnicotinamide are highly upregulated, and NNMT is required for low S-adenosyl methionine (SAM) levels and the H3K27me3 repressive state. NNMT consumes SAM in naive cells, making it unavailable for histone methylation that represses Wnt and activates the HIF pathway in primed hESCs. These data support the hypothesis that the metabolome regulates the epigenetic landscape of the earliest steps in human development