Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome

Aim: The aim of this study was to assess the insulin resistance andserum leptin levels in patients with obstructive sleep apnea syndrome(OSAS), and to compare body mass indexes (BMI) of OSAS patients withmatched controls without OSAS.Method: Twenty eight patients having apnea-hypopnea index (AHI)?5included in the study. Thirty two healthy subjects assumed as a controlgroup. Venous blood was obtained in the fasting state for themeasurement of glucose, insulin and leptin levels. Insulin resistanceindex was based on the homeostasis model assesment method (HOMAIR).Result: There was no significant difference in the serum leptin levels(control group, 32.88±24.22 ng/ml, OSAS group, 24.93±25.84 ng/ml) and HOMA-IR (control group, 3.01±1.81, OSAS group, 2.58±1.21)between control group and OSAS patients. Insulin resistance and circulatingplasma leptin concentrations in OSAS patients were independentof the AHI and were not different from the control group.Conclusion: We concluded that insulin resistance and plasma leptinconcentrations are mostly associated with the degree of obesity andBMI. Those parameters seem not to be related with the AHI in OSASpatients

Inflammatory Rectal Polyp with Osseous Metaplasia: Is It a Distinctive Disease Entity?

Osseous metaplasia is a heterotopic bone formation and it is encountered rarely in the gastrointestinal tract, especially in benign lesions. Although its pathophysiology is not known clearly, there are several theories suggested. In this case report, we presented a case of bone formation in a rectal inflammatory polyp presenting with rectal bleeding in a 7-year-old girl. Therewithal, we reviewed the literature and summarized the subject of osseous metaplasia in colon polyps. We detected some similarities in the cases presented that suggest it might be a distinctive disease entity. Osseous metaplasia in colorectal polyps is extremely rare. To our knowledge, this is the eleventh reported case of osseous metaplasia in a rectal inflammatory polyp. Although osseous metaplasia in colon polyps has not a significant effect on both clinic and the prognosis, it can be confusing when encountered in microscopic examination

MEDIATING EFFECT OF PESSIMISTIC EVALUATIONS ABOUT THE ENVIRONMENT ON THE RELATION BETWEEN LEARNED HELPLESSNESS AND FIRMS' ENVIRONMENTAL SOCIAL RESPONSIBILITY

The purpose of this study is to investigate learned helplessness and pessimistic evaluations of individuals about the environment with their attitudes toward firms' environmental social responsibility behaviors. The study conducted on 125 business administration students by asking them to fill out a questionnaire, in which learned helplessness was measured by McLean, A. (2003), environmental concern were taken from Dunlap et. al. (2000) and social responsibility survey developed by Karahan (2006) were used. In order to examine the relationships between the variables linear regression analysis was conducted and to understand the mediating effects of firm's social responsibility multiple regression analysis was used. Regression results revealed that pessimistic evaluation about environment fully mediated the influence of learned helplessness on attitudes of individuals toward firms' environmental social responsibility behaviors. The implications of the study for research and practice are discussed and some suggestions are made for future research as well as the strengths and limitations of the study

Obstrüktif uyku apne sendromu olan erkek hastalarda insülin rezistansı ve serum leptin seviyeleri

Amaç: Bu çalışmanın amacı obstrüktif uyku apne sendromu (OUAS) olan hastalarda insülin rezistansı ve serum leptin seviyelerini incelemek ve OUAS olan hastaların vücut kitle indeksini (VCİ) kontrol grubuyla karşılaştırmaktır. Metod: Apne hipopne indeksi (AHİ)?5 olan 28 hasta çalışmaya dahil edildi. Sağlıklı 32 birey kontrol grubu olarak kullanıldı. Çalışmaya katılan bireylerden glukoz, insülin ve leptin seviyelerini ölçmek için açlık durumunda venöz kan elde edildi. İnsülin rezistans indeksinde, hemostaz modeli analiz methodu (HOMA-IR) temel alındı. Bulgular: OUAS grubu ile kontrol grubu arasında serum leptin seviyeleri (kontrol grubu, 32.88 ± 24.22 ng/ml, OUAS grubu, 24.93 ± 25.84 ng/ml) ve HOMA-IR (kontrol grubu, 3.01 ± 1.81, OUAS grubu, 2.58 ± 1.21) açısından anlamlı bir fark yoktu. OUAS olan hastalarda insülin rezistansı ve plazma leptin konsantrasyonları AHİ’den bağımsızdı ve kontrol grubundan farklı değildi. Sonuç: İnsülin rezistansı ve plazma leptin konsantrasyonları sıklıkla VKİ ve obesitenin derecesiyle ilişkili olduğunu düşünüyoruz. Bu parametreler OUAS olan hastalarda AHİ ile ilişkili olmadığı gözükmektedr.Aim: The aim of this study was to assess the insulin resistance and serum leptin levels in patients with obstructive sleep apnea syndrome (OSAS), and to compare body mass indexes (BMI) of OSAS patients with matched controls without OSAS. Method: Twenty eight patients having apnea-hypopnea index (AHI)≥5 included in the study. Thirty two healthy subjects assumed as a control group. Venous blood was obtained in the fasting state for the measurement of glucose, insulin and leptin levels. Insulin resistance index was based on the homeostasis model assesment method (HOMA-IR). Result: There was no significant difference in the serum leptin levels (control group, 32.88±24.22 ng/ml, OSAS group, 24.93±25.84 ng/ml) and HOMA-IR (control group, 3.01±1.81, OSAS group, 2.58±1.21) between control group and OSAS patients. Insulin resistance and circulating plasma leptin concentrations in OSAS patients were independent of the AHI and were not different from the control group. Conclusion: We concluded that insulin resistance and plasma leptin concentrations are mostly associated with the degree of obesity and BMI. Those parameters seem not to be related with the AHI in OSAS patients