Aim: The aim of this study was to assess the insulin resistance andserum leptin levels in patients with obstructive sleep apnea syndrome(OSAS), and to compare body mass indexes (BMI) of OSAS patients withmatched controls without OSAS.Method: Twenty eight patients having apnea-hypopnea index (AHI)?5included in the study. Thirty two healthy subjects assumed as a controlgroup. Venous blood was obtained in the fasting state for themeasurement of glucose, insulin and leptin levels. Insulin resistanceindex was based on the homeostasis model assesment method (HOMAIR).Result: There was no significant difference in the serum leptin levels(control group, 32.88±24.22 ng/ml, OSAS group, 24.93±25.84 ng/ml) and HOMA-IR (control group, 3.01±1.81, OSAS group, 2.58±1.21)between control group and OSAS patients. Insulin resistance and circulatingplasma leptin concentrations in OSAS patients were independentof the AHI and were not different from the control group.Conclusion: We concluded that insulin resistance and plasma leptinconcentrations are mostly associated with the degree of obesity andBMI. Those parameters seem not to be related with the AHI in OSASpatients
