lessons learned and future trends

Funding Information: Thanks are due to CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020), and ToxOmics (UIDB/00009/2020; UIDP/00009/2020), through national funds. L.B. thanks Research Infrastructure RECETOX RI (No. LM2018121), financed by the Ministry of Education, Youth and Sports, and the project CETOCOEN EXCELLENCE (No. CZ.02.1.01/0.0/0.0/17_043/0009632) for a supportive background of the European Union’s Horizon 2020 research and innovation program under grant agreement No. 857560, and to the HBM4EU, under grant agreement No. 733032. This publication reflects only the authors’ view and the European Commission is not responsible for any use that may be made of the information it contains. Funding Information: This study was co-funded by the HBM4EU, which has received funding from the European Union’s research and innovation programme Horizon 2020 under grant agreement No. 733032, and from the authors’ institutions. Publisher Copyright: © 2022 by the authors.Mycotoxins are natural metabolites produced by fungi that contaminate food and feed worldwide. They can pose a threat to human and animal health, mainly causing chronic effects, e.g., immunotoxic and carcinogenic. Due to climate change, an increase in European population exposure to mycotoxins is expected to occur, raising public health concerns. This urges us to assess the current human exposure to mycotoxins in Europe to allow monitoring exposure and prevent future health impacts. The mycotoxins deoxynivalenol (DON) and fumonisin B1 (FB1) were considered as priority substances to be studied within the European Human Biomonitoring Initiative (HBM4EU) to generate knowledge on internal exposure and their potential health impacts. Several policy questions were addressed concerning hazard characterization, exposure and risk assessment. The present article presents the current advances attained under the HBM4EU, research needs and gaps. Overall, the knowledge on the European population risk from exposure to DON was improved by using new harmonised data and a newly derived reference value. In addition, mechanistic information on FB1 was, for the first time, organized into an adverse outcome pathway for a congenital anomaly. It is expected that this knowledge will support policy making and contribute to driving new Human Biomonitoring (HBM) studies on mycotoxin exposure in Europe.publishersversionpublishe

Current Advances, Research Needs and Gaps in Mycotoxins Biomonitoring under the HBM4EU-Lessons Learned and Future Trends

ReviewThis article belongs to the Special Issue Human Biomonitoring and Risk Assessment of Mycotoxins.Mycotoxins are natural metabolites produced by fungi that contaminate food and feed worldwide. They can pose a threat to human and animal health, mainly causing chronic effects, e.g., immunotoxic and carcinogenic. Due to climate change, an increase in European population exposure to mycotoxins is expected to occur, raising public health concerns. This urges us to assess the current human exposure to mycotoxins in Europe to allow monitoring exposure and prevent future health impacts. The mycotoxins deoxynivalenol (DON) and fumonisin B1 (FB1) were considered as priority substances to be studied within the European Human Biomonitoring Initiative (HBM4EU) to generate knowledge on internal exposure and their potential health impacts. Several policy questions were addressed concerning hazard characterization, exposure and risk assessment. The present article presents the current advances attained under the HBM4EU, research needs and gaps. Overall, the knowledge on the European population risk from exposure to DON was improved by using new harmonised data and a newly derived reference value. In addition, mechanistic information on FB1 was, for the first time, organized into an adverse outcome pathway for a congenital anomaly. It is expected that this knowledge will support policy making and contribute to driving new Human Biomonitoring (HBM) studies on mycotoxin exposure in Europe.This study was co-funded by the HBM4EU, which has received funding from the European Union’s research and innovation programme Horizon 2020 under grant agreement No. 733032, and from the authors’ institutions. Thanks are due to CESAM(UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020), and ToxOmics (UIDB/00009/2020; UIDP/00009/2020), through national funds. L.B. thanks Research Infrastructure RECETOX RI (No. LM2018121), financed by the Ministry of Education, Youth and Sports, and the project CETOCOEN EXCELLENCE (No. CZ.02.1.01/0.0/0.0/17_043/0009632) for a supportive background of the European Union’s Horizon 2020 research and innovation program under grant agreement No. 857560, and to the HBM4EU, under grant agreement No. 733032.info:eu-repo/semantics/publishedVersio

Mycotoxins human biomonitoring under HBM4EU: the case study of deoxynivalenol and fumonisin B1

Baseado no artigo publicado: Alvito P, A ssunção RM, Bajard L, Mar tins C, Mengelers M, Hans Mol, Van den Brand A, Namorado S, Vasco E, Viegas S, Silva M. Current advances, research needs and gaps in Mycotoxins Biomonitoring under HBM4EU – lessons learned and future t rends. Toxins (Basel ). 2022;14(12):826. https://doi.org/10.3390/toxins14120826As micotoxinas são toxinas naturais produzidas por fungos, apresentando efeitos tóxicos para o homem e para os animais. Reconhece-se, atualmente, que as alterações climáticas terão impacto na distribuição geográfica de algumas espécies de fungos produtores de micotoxinas o que se traduzirá, previsivelmente, num aumento da exposição humana a estes compostos. Pelas razões descritas, urge conhecer a atual exposição a micotoxinas na Europa, com vista à sua futura monitorização e à prevenção/redução do seu impacto na saúde. No âmbito da Iniciativa Europeia em Biomonitorização Humana (HBM4EU) consideraram-se as micotoxinas desoxinivalenol (DON) e fumonisina B1 (FB1) como substâncias prioritárias, tendo sido abordadas várias questões relativas à avaliação da exposição humana e o potencial risco para a saúde. No presente artigo, apresentam-se as questões identificadas como mais importantes, respostas obtidas e perspetivas futuras. Os resultados confirmaram a exposição humana a DON, tendo sido obtidos, pela primeira vez, dados harmonizados de exposição ao nível europeu e derivado um valor de referência para essa exposição. Foi ainda proposto, pela primeira vez no HBM4EU, uma sucessão de eventos biológicos baseados no mecanismo de ação da FB1 que permitiu associar a exposição durante a gravidez ao desenvolvimento de defeitos do tubo neural no feto. Espera-se que estes resultados possam contribuir para uma futura monitorização da exposição a micotoxinas na Europa e para melhorar a avaliação de risco destas substâncias.Mycotoxins are natural low-molecular-weight toxins produced by fungal species that can be toxic for humans and animals. Under the climate change scenario, some fungal species might shift their geographical distribution in response to global warming, leading to changes in the pattern of mycotoxin occurrence and, thus, increasing the risk of human mycotoxin exposure. For this reason, it urges to assess the current human exposure to mycotoxins in Europe, to monitor internal exposure and prevent future health impact. The European Human Biomonitoring Initiative (HBM4EU), running from 2017 to 2022, was set to generate knowledge on internal exposure and their potential health impacts. Within this initiative, the mycotoxins deoxynivalenol (DON) and fumonisin B1 ( FB1) were considered as priority substances to be studied and several policy questions were addressed concerning their risk assessment. The present paper presents policy questions identified within HBM4EU for these mycotoxins, answers obtained and future perspectives. The exposure of the general European population to DON was confirmed using new harmonized data and a reference guidance value for human biomonitoring was set for the first time. Additionaly, an adverse outcome pathway for neural tube defects was proposed for FB1 for the first time. Hopefully these findings may contribute to a more accurate risk assessment of European population´s exposure to mycotoxins.O projeto HBM4EU recebeu financiamento do programa de investigação e inovação da União Europeia Horizonte 2020 sob o contrato de concessão n.º 733032 e das instituições em que os autores desenvolvem as suas atividades. Os autores agradecem à FCT/MCTES pelo financiamento com fundos nacionais relativos ao CESAM (UIDP/50017/2020+UIDB/ DB/50017/2020) e ToxOmics (UIDB/00009/2020; UIDP/00009/ 2020).info:eu-repo/semantics/publishedVersio

Atlas urbain de Grenoble

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Atlas urbain de Grenoble

L'équipe de recherche attachée à l’école d'Architecture de Grenoble présente ici ses travaux pour l'année 1988. Ceux-ci portent sur la cartothèque de l’école d'Architecture de Grenoble, l'utilisation du D.A.O. (dessin assisté par ordinateur) dans l'analyse et la représentation des formes urbaines, l'urbanisme de l'entre-deux-guerres à Grenoble et sur le grand garage hélicoïdal

La Grande Histoire des Alpages : une histoire d’avenir. Partage des connaissances sur l'histoire des alpages

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Tumor cell survival in response to swift-ion irradiation

International audienc

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International audienc