Miniaturized atmospheric ionization detector

A small scintillator-based detector for atmospheric ionization measurements has been developed, partly in response to a need for better ionization data in the weather-forming regions of the atmosphere and partly with the intention of producing a commercially available device. The device can measure both the count rate and energy of atmospheric ionizing radiation. Here we report results of a test flight over the UK in December 2017 where the detector was flown with two Geiger counters on a meteorological radiosonde. The count rate profile with height was consistent both with the Geigers and with previous work. The energy of incoming ionizing radiation increased substantially with altitude.Comment: Proc 18th Conference on Atmospheric Electricity, Nara, Japan, June 201

Aboriginal Health Consumers Experiences of an Aboriginal Health Curriculum Framework

Introduction In settler colonised countries medical education is situated in colonist informed health systems. This form of colonisation is characterised by overt racism and contributes to the significant health inequities experienced by Indigenous peoples. Not surprisingly, medical accreditation bodies in these countries have mandated the curriculum include content relating to Indigenous peoples. However, what is absent is the Indigenous health consumer worldview of health care and their nuanced lived experience of the delivery of medical care. Methods Yarning methods, integral to Aboriginal peoples’ ways of understanding and learning, were utilised. A Yarning guide was constructed with Social Yarn and Research Topic Yarn questions to understand Aboriginal health consumer experiences of the five learning domains within the Aboriginal and Torres Strait Islander Health Curriculum Framework. Data were analysed using Framework Analysis. Results Seventeen Aboriginal adults from urban and rural areas participated in the Yarns during 2018 and 2019. Coding and mapping data identified medical practitioner enacting practices that either perpetuated racism and the settler colonial ideology or facilitated anti-racist health care. Unwanted care included three racism themes described as the practitioner perpetuating and being unresponsive to racism; assimilation and an inability to consider impacts of settler colonialism. Desired care included four anti-racist themes expressed as responsiveness to racism and settler colonialism; advocating within the settler colonial health system; engaging with diversity of Aboriginal ways of knowing, being and doing and lifelong learning and reflection. Conclusion Medical practitioners are promoting ill health through racist practices with Aboriginal health consumers. Aboriginal people’s experiences of racism via continued settler colonial processes and anti-racism in the Australian health system, are critical to meaningful curricula. However, there is a risk for tokenism if the academy continues its coloniality by privileging the biomedical model of illness and health over other models of health

Intersectionality Based Policy Analysis of How Racism is Framed in Medical Education Policies Guiding Aboriginal Health Curriculum

Introduction: Racism has a profound impact on health inequities for Aboriginal and Torres Strait Islander people. Australian medical schools are required to include Aboriginal and Torres Strait Islander health curriculum in their medical courses and policies have been developed to support this work. Methods: The research question was: how is racism framed in medical education policies guiding Aboriginal and Torres Strait Islander health curriculum for entry-level medical courses? Applying an Indigenous Research Paradigm and Intersectionality Based Policy Analysis, three key policies were analysed: Australian Medical Council (AMC) Standards for Assessment and Accreditation of Primary Medical programs; Aboriginal and Torres Strait Islander Health Curriculum Framework (ATSIHCF); Committee of Deans of Australasian Medical Schools Indigenous Health Curriculum Framework (CDAMS). Results: The AMC standards did not refer to racism, while CDAMS and ATSICF supported the notion that teaching students about racism would lead to reduced racism or increased anti-racism in healthcare practice. However, both policies’ learning objectives lacked inclusion of critical reflection required to inform responsive action to racism. As the CDAMS and ATSIHCF were not mandated, there is little accountability for medical schools to implement either of the curriculum policies. Conclusion: Realising the goal of medical practitioners who understand racism and practice anti-racism requires a multi-layered approach. This involves evidence-based teaching about racism and anti-racism, Aboriginal and Torres Strait Islander leadership in curriculum development, inclusion of racism and anti-racism in medical school accreditation standards, and development of student critical reflection skills. Importantly, education and health institutions need to value and model anti-racism

“A safe haven to support me”: an evaluation report on the Central Coast Family Wellbeing Program

A significant proportion of young people in Australia including the NSW Central Coast region are not engaged in school, work and other social systems. The consequences of disengagement can be profound and are linked to higher rates of social and mental health problems, including suicide, alcohol and drug use. Being male and Indigenous are amongst the key factors identified as being risks for youth disengagement. This report presents an analysis of the Family Wellbeing (FWB) program on the NSW Central Coast. FWB implementation is designed to enhance the social and emotional wellbeing of young Aboriginal men and improve engagement in education, employment and other social and cultural participation. The report draws attention to the need for more sustainable funding for promising programs such as the Central Coast FWB including properly resourced long-term evaluation. Insecurity and loss of funding means a loss of opportunity for future participants to be supported, mentored and engaged in learning and employment. It will also impact on those who have completed FWB and who rely on the FWB network for ongoing support

The use of social robots with children and young people on the autism spectrum: A systematic review and meta-analysis

© 2022 Kouroupa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/Background: Robot-mediated interventions show promise in supporting the development of children on the autism spectrum. Objectives: In this systematic review and meta-analysis, we summarize key features of available evidence on robot-interventions for children and young people on the autism spectrum aged up to 18 years old, as well as consider their efficacy for specific domains of learning. Data sources: PubMed, Scopus, EBSCOhost, Google Scholar, Cochrane Library, ACM Digital Library, and IEEE Xplore. Grey literature was also searched using PsycExtra, OpenGrey, British Library EThOS, and the British Library Catalogue. Databases were searched from inception until April (6th) 2021. Synthesis methods: Searches undertaken across seven databases yielded 2145 articles. Forty studies met our review inclusion criteria of which 17 were randomized control trials. The methodological quality of studies was conducted with the Quality Assessment Tool for Quantitative Studies. A narrative synthesis summarised the findings. A meta-analysis was conducted with 12 RCTs. Results: Most interventions used humanoid (67%) robotic platforms, were predominantly based in clinics (37%) followed home, schools and laboratory (17% respectively) environments and targeted at improving social and communication skills (77%). Focusing on the most common outcomes, a random effects meta-analysis of RCTs showed that robot-mediated interventions significantly improved social functioning (g = 0.35 [95%CI 0.09 to 0.61; k = 7). By contrast, robots did not improve emotional (g = 0.63 [95%CI -1.43 to 2.69]; k = 2) or motor outcomes (g = -0.10 [95%CI -1.08 to 0.89]; k = 3), but the numbers of trials were very small. Meta-regression revealed that age accounted for almost one-third of the variance in effect sizes, with greater benefits being found in younger children. Conclusions: Overall, our findings support the use of robot-mediated interventions for autistic children and youth, and we propose several recommendations for future research to aid learning and enhance implementation in everyday settings. PROSPERO registration: Our methods were preregistered in the PROSPERO database (CRD42019148981).Peer reviewe

Factors That Influence Linkages to HIV Continuum of Care Services: Implications for Multi-Level Interventions

Worldwide, the human immunodeficiency virus (HIV) continuum of care involves health promotion providers (e.g., social workers and health educators) linking patients to medical personnel who provide HIV testing, primary care, and antiretroviral treatments. Regrettably, these life-saving linkages are not always made consistently and many patients are not retained in care. To design, test and implement effective interventions, we need to first identify key factors that may improve linkage-making. To help close this gap, we used in-depth interviews with 20 providers selected from a sample of 250 participants in a mixed-method longitudinal study conducted in New York City (2012–2017) in order to examine the implementation of HIV services for at-risk populations. Following a sociomedical framework, we identified provider-, interpersonal- and environmental-level factors that influence how providers engage patients in the care continuum by linking them to HIV testing, HIV care, and other support services. These factors occurred in four domains of reference: Providers’ Professional Knowledge Base; Providers’ Interprofessional Collaboration; Providers’ Work-Related Changes; and Best Practices in a Competitive Environment. Of particular importance, our findings show that a competitive environment and a fear of losing patients to other agencies may inhibit providers from engaging in linkage-making. Our results suggest relationships between factors within and across all four domains; we recommend interventions to modify factors in all domains for maximum effect toward improving care continuum linkage-making. Our findings may be applicable in different areas of the globe with high HIV prevalence

Unexpected patterns of global population structure in melon-headed whales Peponocephala electra

Foraging specialization, environmental barriers, and social structure have driven the development of strong genetic differentiation within many marine species, including most of the large dolphin species commonly referred to as ‘blackfish’ (subfamily Globicephalinae). We used mitochondrial sequence data (mtDNA) and genotypes from 14 nuclear microsatellite loci (nDNA) to examine patterns of genetic population structure in melon-headed whales Peponocephala electra (MHWs), poorly known members of the blackfish family for which genetic structuring is unknown. MHWs are globally distributed in tropical and subtropical waters, and have formed resident populations around oceanic islands. They frequently mass strand, suggesting strong social cohesion within groups. Based on these characteristics, we hypothesized that MHWs would exhibit strong regional genetic differentiation, similar to that observed in other members of the Globicephalinae subfamily. Instead we found only moderate differentiation (median mtDNA ΦST = 0.204, median nDNA FST = 0.012) among populations both within and between ocean basins. Our results suggest that populations of MHWs that are resident to oceanic islands maintain a higher level of genetic connectivity than is seen in most other blackfish. MHWs may be more behaviorally similar to delphinids from the Delphininae subfamily (particularly the spinner dolphin Stenella longirostris), which are known to form coastal and island-associated resident populations that maintain genetic connectivity either through occasional long-distance dispersal or gene flow with larger pelagic populations. Our results suggest that differences in social organization may drive different patterns of population structure in social odontocete

Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.

BACKGROUND: Several recent studies have provided evidence that polymorphisms in the telomerase reverse transcriptase (TERT) gene sequence are associated with cancer development, but a comprehensive synopsis is not available. We conducted a systematic review and meta-analysis of the available molecular epidemiology data regarding the association between TERT locus polymorphisms and predisposition to cancer. METHODS: A systematic review of the English literature was conducted by searching PubMed, Embase, Cancerlit, Google Scholar, and ISI Web of Knowledge databases for studies on associations between TERT locus polymorphisms and cancer risk. Random-effects meta-analysis was performed to pool per-allele odds ratios for TERT locus polymorphisms and risk of cancer, and between-study heterogeneity and potential bias sources (eg, publication and chasing bias) were assessed. Because the TERT locus includes the cleft lip and palate transmembrane 1-like (CLPTM1L) gene, which is in linkage disequilibrium with TERT, CLPTM1L polymorphisms were also analyzed. Cumulative evidence for polymorphisms with statistically significant associations was graded as "strong," "moderate," and "weak" according to the Venice criteria. The joint population attributable risk was calculated for polymorphisms with strong evidence of association. RESULTS: Eighty-five studies enrolling 490 901 subjects and reporting on 494 allelic contrasts were retrieved. Data were available on 67 TERT locus polymorphisms and 24 tumor types, for a total of 221 unique combinations of polymorphisms and cancer types. Upon meta-analysis, a statistically significant association with the risk of any cancer type was found for 22 polymorphisms. Strong, moderate, and weak cumulative evidence for association with at least one tumor type was demonstrated for 11, 9, and 14 polymorphisms, respectively. For lung cancer, which was the most studied tumor type, the estimated joint population attributable risk for three polymorphisms (TERT rs2736100, intergenic rs4635969, and CLPTM1L rs402710) was 41%. Strong evidence for lack of association was identified for five polymorphisms in three tumor types. CONCLUSIONS: To our knowledge, this is the largest collection of data for associations between TERT locus polymorphisms and cancer risk. Our findings support the hypothesis that genetic variability in this genomic region can modulate cancer susceptibility in humans.This work was in part supported by a grant from the Italian Association for Research on Cancer (AIRC Veneto Regional fund 2008-2011 to SM and DN).This is the author accepted manuscript. The final version is available from Oxford University Press via http://dx.doi.org/10.1093/jnci/djs22

Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system

Background: Because the choroid plexus (CP) is uniquely suited to control the composition of cerebrospinal fluid (CSF), there may be therapeutic benefits to increasing the levels of biologically active proteins in CSF to modulate central nervous system (CNS) functions. To this end, we sought to identify peptides capable of ligand-mediated targeting to CP epithelial cells reasoning that they could be exploited to deliver drugs, biotherapeutics and genes to the CNS.Methods: A peptide library displayed on M13 bacteriophage was screened for ligands capable of internalizing into CP epithelial cells by incubating phage with CP explants for 2 hours at 37C and recovering particles with targeting capacity.Results: Three peptides, identified after four rounds of screening, were analyzed for specific and dose dependant binding and internalization. Binding was deemed specific because internalization was prevented by co-incubation with cognate synthetic peptides. Furthermore, after i.c.v. injection into rat brains, each peptide was found to target phage to epithelial cells in CP and to ependyma lining the ventricles.Conclusion: These data demonstrate that ligand-mediated targeting can be used as a strategy for drug delivery to the central nervous system and opens the possibility of using the choroid plexus as a portal of entry into the brain