Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks.

In this study, we quantify the severity of drug-induced dyskinesias in the arms of Parkinson's disease (PD) patients using digitised spiral-drawing tasks. Two spiral drawings, namely a circular and a square spiral, are designed to, respectively, represent the continuous and discrete arm motions, and the size of the spiral is decided so that both the distal and proximal arm joints are involved. Fifteen PD patients, average disease duration 14.4+/-7.4 years, were assessed 30 min after a levodopa challenge whilst performing circular and square spiral-drawing tasks. The velocity of drawing movements was computed and the amplitude of the involuntary dyskinetic movements was measured as the standard deviation of the drawing velocity (SD-DV). The mean amplitude of dyskinetic movements was compared between arms and tasks and was correlated with clinical measures including the Bain dyskinesia scale and the total unified Parkinson's disease rating scale (UPDRS) score. The results showed that there was no statistically significant difference in the amplitude of dyskinesias either between the arms or between the continuous (circular) and discrete (square) spiral drawings in this group of PD patients, but interestingly the interaction between arm and drawing pattern was significant. Significant correlations were found between the magnitude of dyskinesia measured from the spiral-drawing tasks and both the 'on' or 'off' UPDRS and also the Bain dyskinesia scale. We conclude that the drawing tasks may be used to provide an objective method of quantifying the severity of drug-induced dyskinesias in the arm in PD patients

A global perspective on drinking-water and sanitation classification: an evaluation of census content

Following the recent expiry of the United Nations’ 2015 Millennium Development Goals (MDGs), new international development agenda covering 2030 water, sanitation and hygiene (WASH) targets have been proposed, which imply new demands on data sources for monitoring relevant progress. This study evaluates drinking-water and sanitation classification systems from national census questionnaire content, based upon the most recent international policy changes, to examine national population census’s ability to capture drinking-water and sanitation availability, safety, accessibility, and sustainability. In total, 247 censuses from 83 low income and lower-middle income countries were assessed using a scoring system, intended to assess harmonised water supply and sanitation classification systems for each census relative to the typology needed to monitor the proposed post-2015 indicators of WASH targets. The results signal a lack of international harmonisation and standardisation in census categorisation systems, especially concerning safety, accessibility, and sustainability of services in current census content. This suggests further refinements and harmonisation of future census content may be necessary to reflect ambitions for post-2015 monitoring

D-branes in PP-Waves and Massive Theories on Worldsheet with Boundary

We investigate the supersymmetric D-brane configurations in the pp-wave backgrounds proposed by Maldacena and Maoz. We study the surviving supersymmetry in a D-brane configuration from the worldvolume point of view. When we restrict ourselves to the background with N=(2,2) supersymmetry and no holomorphic Killing vector term, there are two types of supersymmetric D-branes: A-type and B-type. An A-type brane is wrapped on a special Lagrangian submanifold, and the imaginary part of the superpotential should be constant on its worldvolume. On the other hand, a B-type brane is wrapped on a complex submanifold, and the superpotential should be constant on its worldvolume. The results are almost consistent with the worldsheet theory in the lightcone gauge. The inclusion of gauge fields is also discussed and found BPS D-branes with the gauge field excitations. Furthermore, we consider the backgrounds with holomorphic Killing vector terms and N=(1,1) supersymmetric backgrounds.Comment: 27 pages, LaTeX, no figure. v2: typos corrected, comments added, references added. v3: typos corrected, comments added, references added. v4:typos correcte

Self Running Droplet: Emergence of Regular Motion from Nonequilibrium Noise

Spontaneous motion of an oil droplet driven by chemical nonequilibricity is reported. It is shown that the droplet undergoes regular rhythmic motion under appropriately designed boundary conditions, whereas it exhibits random motion in an isotropic environment. This study is a novel manifestation on the direct energy transformation of chemical energy into regular spatial-motion under isothermal conditions. A simple mathematical equation including noise reproduces the essential feature of the transition from irregularity into periodic regular motion. Our results will inspire the theoretical study on the mechanism of molecular motors in living matter, working under significant influence of thermal fluctuation.Comment: 4 pages, 4 figure

Tadpole Analysis of Orientifolded Plane-Waves

We study orientifolds of type IIB string theory in the plane-wave background supported by null RR 3-form flux F^{(3)}. We describe how to extract the RR tadpoles in the Green-Schwarz formalism in a general setting. Two models with orientifold groups {1, \Omega} and {1,\Omega I_4}, which are T-dual to each other, are considered. Consistency of these backgrounds requires 32 D9 branes for the first model and 32 D5 branes for the second one. We study the spectra and comment on the heterotic duals of our models.Comment: 22+1 pages, 3 figures References added, minor typos correcte

Malnutrition in Sub – Saharan Africa: burden, causes and prospects

Malnutrition is estimated to contribute to more than one third of all child deaths, although it is rarely listed as the direct cause. Contributing to more than half of deaths in children worldwide; child malnutrition was associated with 54% of deaths in children in developing countries in 2001. Poverty remains the major contributor to this ill. The vicious cycle of poverty, disease and illness aggravates this situation. Grooming undernourished children causes children to start life at mentally sub optimal levels. This becomes a serious developmental threat. Lack of education especially amongst women disadvantages children, especially as far as healthy practices like breastfeeding and child healthy foods are concerned. Adverse climatic conditions have also played significant roles like droughts, poor soils and deforestation. Sociocultural barriers are major hindrances in some communities, with female children usually being the most affected. Corruption and lack of government interest and investment are key players that must be addressed to solve this problem. A multisectorial approach is vital in tackling this problem. Improvement in government  policy, fight against corruption, adopting a horizontal approach in implementing programmes at community level must be recognized. Genetically modified foods to increase food production and to survive adverse climatic conditions could be gateways in solving these problems. Socio cultural peculiarities of each community are an essential base line consideration for the implementation of any nutrition health promotion programs.Key words: Malnutrition, Sub–Saharan Africa, corruption, multisectorial approac

Notes on Giant Gravitons on PP-waves

We investigate the giant gravitons in the maximally supersymmetric IIB pp-wave from several viewpoints: (i) the dynamics of D3-branes, (ii) the world-sheet description and (iii) the correlation functions in the dual N=4 Yang-Mills theory. In particular, we derive the BPS equation of a D3-brane with magnetic flux, which is equivalent to multiple D-strings, and discuss the behavior of solutions in the presence of RR-flux. We find solutions which represent the excitations of the giant gravitons in that system.Comment: 25 pages, Latex, typos corrected, (minor) factors in eq.(2.11),(2.12),(2.16),(2.17) corrected, a footnote added, to appear in JHE

Branes in the plane wave background with gauge field condensates

Supersymmetric branes in the plane wave background with additional constant magnetic fields are studied from the world-sheet point of view. It is found that in contradistinction to flat space, boundary condensates on some maximally supersymmetric branes necessarily break at least some supersymmetries. The maximally supersymmetric cases with condensates are shown to be in one to one correspondence with the previously classified class II branes.Comment: LaTeX, 31 pages, no figures; v2: references added, some typos correcte

Tumor site immune markers associated with risk for subsequent basal cell carcinomas.

BackgroundBasal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic.ObjectiveThe goal of this study was to assess how immune-cell related gene expression in an initial BCC tumor biopsy was related to the appearance of subsequent BCC tumors.Materials and methodsLevels of mRNA for CD3ε (a T-cell receptor marker), CD25 (the alpha chain of the interleukin (IL)-2 receptor expressed on activated T-cells and B-cells), CD68 (a marker for monocytes/macrophages), the cell surface glycoprotein intercellular adhesion molecule-1 (ICAM-1), the cytokine interferon-γ (IFN-γ) and the anti-inflammatory cytokine IL-10 were measured in BCC tumor biopsies from 138 patients using real-time PCR.ResultsThe median follow-up was 26.6 months, and 61% of subjects were free of new BCCs two years post-initial biopsy. Patients with low CD3ε CD25, CD68, and ICAM-1 mRNA levels had significantly shorter times before new tumors were detected (p = 0.03, p = 0.02, p = 0.003, and p = 0.08, respectively). Furthermore, older age diminished the association of mRNA levels with the appearance of subsequent tumors.ConclusionsOur results show that levels of CD3ε, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new BCC tumors

Smearing Effect in Plane-Wave Matrix Model

Motivated by the usual D2-D0 system, we consider a configuration composed of flat membrane and fuzzy sphere membrane in plane-wave matrix model, and investigate the interaction between them. The configuration is shown to lead to a non-trivial interaction potential, which indicates that the fuzzy sphere membrane really behaves like a graviton, giant graviton. Interestingly, the interaction is of r^{-3} type rather than r^{-5} type. We interpret it as the interaction incorporating the smearing effect due to the fact that the considered supersymmetric flat membrane should span and spin in four dimensional subspace of plane-wave geometry.Comment: 26 pages; added referenc