CFD Mixing Analysis of Jets Injected from Straight and Slanted Slots into Confined Crossflow in Rectangular Ducts

A CFD study was performed to analyze the mixing potential of opposed rows of staggered jets injected into confined crossflow in a rectangular duct. Three jet configurations were numerically tested: (1) straight (0 deg) slots; (2) perpendicular slanted (45 deg) slots angled in opposite directions on top and bottom walls; and (3) parallel slanted (45 deg) slots angled in the same direction on top and bottom walls. All three configurations were tested at slot spacing-to-duct height ratios (S/H) of 0.5, 0.75, and 1.0; a jet-to-mainstream momentum flux ratio (J) of 100; and a jet-to-mainstream mass flow ratio of 0.383. Each configuration had its best mixing performance at S/H of 0.75. Asymmetric flow patterns were expected and predicted for all slanted slot configurations. The parallel slanted slot configuration was the best overall configuration at x/H of 1.0 for S/H of 0.75

CFD mixing analysis of axially opposed rows of jets injected into confined crossflow

A computational fluid dynamics (CFD) parametric study was performed to analyze axially opposed rows of jets mixing with crossflow in a rectangular duct. Isothermal analysis was conducted to determine the influence of lateral geometric arrangement on mixing. Two lateral arrangements were analyzed: (1) inline (jets' centerlines aligned with each other on top and bottom walls), and (2) staggered (jets' centerlines offset with each other on top and bottom walls). For a jet-to-mainstream mass flow ratio (MR) of 2.0, design parameters were systematically varied for jet-to-mainstream momentum-flux ratios (J) between 16 and 64 and orifice spacing-to-duct height ratios (S/H) between 0.125 and 1.5. Comparisons were made between geometries optimized for S/H at a specified J. Inline configurations had a unique spacing for best mixing at a specified J. In contrast, staggered configurations had two 'good mixing' spacings for each J, one corresponding to optimum inline spacing and the other corresponding to optimum non-impinging jet spacing. The inline configurations, due to their smaller orifice size at optimum S/H, produced better initial mixing characteristics. At downstream locations (e.g. x/H of 1.5), the optimum non-impinging staggered configuration produced better mixing than the optimum inline configuration for J of 64; the opposite results were observed for J of 16. Increasing J resulted in better mixing characteristics if each configuration was optimized with respect to orifice spacing. Mixing performance was shown to be similar to results from previous dilution jet mixing investigations (MR less than 0.5)

The structure of causal sets

More often than not, recently popular structuralist interpretations of physical theories leave the central concept of a structure insufficiently precisified. The incipient causal sets approach to quantum gravity offers a paradigmatic case of a physical theory predestined to be interpreted in structuralist terms. It is shown how employing structuralism lends itself to a natural interpretation of the physical meaning of causal sets theory. Conversely, the conceptually exceptionally clear case of causal sets is used as a foil to illustrate how a mathematically informed rigorous conceptualization of structure serves to identify structures in physical theories. Furthermore, a number of technical issues infesting structuralist interpretations of physical theories such as difficulties with grounding the identity of the places of highly symmetrical physical structures in their relational profile and what may resolve these difficulties can be vividly illustrated with causal sets.Comment: 19 pages, 4 figure

Flow Coupling Effects in Jet-in-Crossflow Flowfields

The combustor designer is typically required to design liner orifices that effectively mix air jets with crossflow effluent. CFD combustor analysis is typically used in the design process; however the jets are usually assumed to enter the combustor with a uniform velocity and turbulence profile. The jet-mainstream flow coupling is usually neglected because of the computational expense. This CFD study was performed to understand the effect of jet-mainstream flow coupling, and to assess the accuracy of jet boundary conditions that are commonly used in combustor internal calculations. A case representative of a plenum-fed quick-mix section of a Rich Burn/Quick Mix/Lean Burn combustor (i.e. a jet-mainstream mass-flow ratio of about 3 and a jet-mainstream momentum-flux ratio of about 30) was investigated. This case showed that the jet velocity entering the combustor was very non-uniform, with a low normal velocity at the leading edge of the orifice and a high normal velocity at the trailing edge of the orifice. Three different combustor-only cases were analyzed with uniform inlet jet profile. None of the cases matched the plenum-fed calculations. To assess liner thickness effects, a thin-walled case was also analyzed. The CFD analysis showed the thin-walled jets had more penetration than the thick-walled jets

Mixing of Multiple Jets With a Confined Subsonic Crossflow

This paper summarizes experimental and computational results on the mixing of opposed rows of jets with a confined subsonic crossflow in rectangular ducts. The studies from which these results were excerpted investigated flow and geometric variations typical of the complex 3-D flowfield in the combustion chambers in gas turbine engines. The principal observation was that the momentum-flux ratio, J, and the orifice spacing, S/H, were the most significant flow and geometric variables. Jet penetration was critical, and penetration decreased as either momentum-flux ratio or orifice spacing decreased. It also appeared that jet penetration remained similar with variations in orifice size, shape, spacing, and momentum-flux ratio when the orifice spacing was inversely proportional to the square-root of the momentum-flux ratio. It was also seen that planar averages must be considered in context with the distributions. Note also that the mass-flow ratios and the offices investigated were often very large (jet-to-mainstream mass-flow ratio greater than 1 and the ratio of orifices-area-to-mainstream-cross-sectional-area up to 0.5 respectively), and the axial planes of interest were often just downstream of the orifice trailing edge. Three-dimensional flow was a key part of efficient mixing and was observed for all configurations

The effect of pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perception

© 2016 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of Europe an Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and re production in any medium, provided the original work is properly cited, see https://creativecommons.org/licenses/by/3.0/BACKGROUND AND PURPOSE: Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) reduces the number of falls in patients with Parkinson's disease (PD). It was hypothesized that enhanced sensory processing contributes to this PPN-mediated gait improvement. METHODS: Four PD patients (and eight matched controls) with implanted bilateral PPN and subthalamic nucleus DBS electrodes were assessed on postural (with/without vision) and vestibular perceptual threshold tasks. RESULTS: Pedunculopontine nucleus ON stimulation (compared to OFF) lowered vestibular perceptual thresholds but there was a disproportionate increase in the normal sway increase on going from light to dark. CONCLUSIONS: The disproportionate increased sway with PPN stimulation in the dark may paradoxically improve balance function since mechanoreceptor signals rapidly adapt to continuous pressure stimulation from postural akinesia. Additionally, the PPN-mediated vestibular signal enhancement also improves the monitoring of postural sway. Overall, PPN stimulation may improve sensory feedback and hence balance performance.Peer reviewedFinal Published versio

Exercise-Induced Changes in Metabolic Intermediates, Hormones, and Inflammatory Markers Associated With Improvements in Insulin Sensitivity

OBJECTIVE: To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators. RESEARCH DESIGN AND METHODS: Targeted mass spectrometry and enzyme-linked immunosorbent assays were used to quantify metabolic intermediates, hormones, and inflammatory markers at baseline, after 6 months of exercise training, and 2 weeks after exercise training cessation (n = 53). A principal components analysis (PCA) strategy was used to relate changes in these intermediates to changes in S(I). RESULTS: PCA reduced the number of intermediates from 90 to 24 factors composed of biologically related components. With exercise training, improvements in S(I) were associated with reductions in by-products of fatty acid oxidation and increases in glycine and proline (P < 0.05, R² = 0.59); these relationships were retained 15 days after cessation of exercise training (P < 0.05, R² = 0.34). CONCLUSIONS: These observations support prior observations in animal models that exercise training promotes more efficient mitochondrial β-oxidation and challenges current hypotheses regarding exercise training and glycine metabolism

Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Herein we found that extremely preterm infants with postnatal growth failure have disrupted maturation of the intestinal microbiota, characterized by persistently low diversity, dominance of pathogenic bacteria within the Enterobacteriaceae family, and a paucity of strictly anaerobic taxa including Veillonella relative to infants with appropriate postnatal growth. Metabolomic profiling of infants with growth failure demonstrated elevated serum acylcarnitines, fatty acids, and other byproducts of lipolysis and fatty acid oxidation. Machine learning algorithms for normal maturation of the microbiota and metabolome among infants with appropriate growth revealed a pattern of delayed maturation of the microbiota and metabolome among infants with growth failure. Collectively, we identified novel microbial and metabolic features of growth failure in preterm infants and potentially modifiable targets for intervention

Notes on Giant Gravitons on PP-waves

We investigate the giant gravitons in the maximally supersymmetric IIB pp-wave from several viewpoints: (i) the dynamics of D3-branes, (ii) the world-sheet description and (iii) the correlation functions in the dual N=4 Yang-Mills theory. In particular, we derive the BPS equation of a D3-brane with magnetic flux, which is equivalent to multiple D-strings, and discuss the behavior of solutions in the presence of RR-flux. We find solutions which represent the excitations of the giant gravitons in that system.Comment: 25 pages, Latex, typos corrected, (minor) factors in eq.(2.11),(2.12),(2.16),(2.17) corrected, a footnote added, to appear in JHE