Behavioral simulation and synthesis of biological neuron systems using synthesizable VHDL

Neurons are complex biological entities which form the basis of nervous systems. Insight can be gained into neuron behavior through the use of computer models and as a result many such models have been developed. However, there exists a trade-off between biological accuracy and simulation time with the most realistic results requiring extensive computation. To address this issue, a novel approach is described in this paper that allows complex models of real biological systems to be simulated at a speed greater than real time and with excellent accuracy. The approach is based on a specially developed neuron model VHDL library which allows complex neuron systems to be implemented on field programmable gate array (FPGA) hardware. The locomotion system of the nematode Caenorhabditis elegans is used as a case study and the measured results show that the real time FPGA based implementation performs 288 times faster than traditional ModelSim simulations for the same accuracy

Forage production and utilization in a sprayed Aspen forest in Alberta

In aspen forest in Alberta, Canada, receiving as little as 3 lb/acre of 2,4-D in a single application achieved an annual herbage production of 874 lb/acre 2 years after treatment compared to only 188 lb/acre in the control. Sprayed forest border areas (small aspen) showed a four-fold increase in herbage production. Grasses, sedges, and forbs increased in herbage production in sprayed forests. Only two forbs were detrimentally affected by the herbicides. In the sprayed forest area, even though there was a considerable amount of obstruction, cattle were able to consume 48% of the total herbage and as much as 58% of the green herbage. However, even with the inclusion of 2,4,5-T in the second herbicide application, there were many woody species in the treatment areas with as high or higher densities than in the control.This material was digitized as part of a cooperative project between the Society for Range Management and the University of Arizona Libraries.The Journal of Range Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform August 202

Characterising sand and gravel deposits using electrical resistivity tomography (ERT) : case histories from England and Wales

Electrical Resistivity Tomography (ERT) is a rapidly developing geophysical imaging technique that is now widely used to visualise subsurface geological structure, groundwater and lithological variations. It is being increasingly used in environmental and engineering site investigations, but despite its suitability and potential benefits, ERT has yet to be routinely applied by the minerals industry to sand and gravel deposit assessment and quarry planning. The principal advantages of ERT for this application are that it is a cost-effective non-invasive method, which can provide 2D or 3D spatial models of the subsurface throughout the full region of interest. This complements intrusive sampling methods, which typically provide information only at discrete locations. Provided that suitable resistivity contrasts are present, ERT has the potential to reveal mineral and overburden thickness and quality variations within the body of the deposit. Here we present a number of case studies from the UK illustrating the use of 2D and 3D ERT for sand and gravel deposit investigation in a variety of geological settings. We use these case studies to evaluate the performance of ERT, and to illustrate good practice in the application of ERT to deposit investigation. We propose an integrated approach to site investigation and quarry planning incorporating both conventional intrusive methods and ERT

Monkey-based Research on Human Disease: The Implications of Genetic Differences

Assertions that the use of monkeys to investigate human diseases is valid scientifically are frequently based on a reported 90–93% genetic similarity between the species. Critical analyses of the relevance of monkey studies to human biology, however, indicate that this genetic similarity does not result in sufficient physiological similarity for monkeys to constitute good models for research, and that monkey data do not translate well to progress in clinical practice for humans. Salient examples include the failure of new drugs in clinical trials, the highly different infectivity and pathology of SIV/HIV, and poor extrapolation of research on Alzheimer’s disease, Parkinson’s disease and stroke. The major molecular differences underlying these inter-species phenotypic disparities have been revealed by comparative genomics and molecular biology — there are key differences in all aspects of gene expression and protein function, from chromosome and chromatin structure to post-translational modification. The collective effects of these differences are striking, extensive and widespread, and they show that the superficial similarity between human and monkey genetic sequences is of little benefit for biomedical research. The extrapolation of biomedical data from monkeys to humans is therefore highly unreliable, and the use of monkeys must be considered of questionable value, particularly given the breadth and potential of alternative methods of enquiry that are currently available to scientists

Polarization Measurements of the Polluted White Dwarf G29-38

We have made high-precision polarimetric observations of the polluted white dwarf G29-38 with the HIgh Precision Polarimetric Instrument 2. The observations were made at two different observatories – using the 8.1-m Gemini North Telescope and the 3.9-m Anglo-Australian Telescope – and are consistent with each other. After allowing for a small amount of interstellar polarization, the intrinsic linear polarization of the system is found to be 275.3 ± 31.9 parts per million at a position angle of 90.8 ± 3.8◦ in the SDSS g band. We compare the observed polarization with the predictions of circumstellar disc models. The measured polarization is small in the context of the models we develop, which only allows us to place limits on disc inclination and Bond albedo for optically thin disc geometries. In this case, either the inclination is near-face-on or the albedo is small – likely in the range 0.05–0.15 – which is in line with other debris disc measurements. A preliminary search for the effects of G29-38’s pulsations in the polarization signal produced inconsistent results. This may be caused by beating effects, indicate a clumpy dust distribution, or be a consequence of measurement systematics