908 research outputs found
Nocturnal sleep, daytime sleepiness, and quality of life in stable patients on hemodialysis
BACKGROUND: Although considerable progress has been made in the treatment of chronic kidney disease, compromised quality of life continues to be a significant problem for patients receiving hemodialysis (HD). However, in spite of the high prevalence of sleep complaints and disorders in this population, the relationship between these problems and quality of life remains to be well characterized. Thus, we studied a sample of stable HD patients to explore relationships between quality of life and both subjective and objective measures of nocturnal sleep and daytime sleepiness METHODS: The sample included forty-six HD patients, 24 men and 22 women, with a mean age of 51.6 (10.8) years. Subjects underwent one night of polysomnography followed the next morning by a Multiple Sleep Latency Test (MSLT), an objective measure of daytime sleepiness. Subjects also completed: 1) a brief nocturnal sleep questionnaire; 2) the Epworth Sleepiness Scale; and, 3) the Quality of Life Index (QLI, Dialysis Version) which provides an overall QLI score and four subscale scores for Health & Functioning (H&F), Social & Economic (S&E), Psychological & Spiritual (P&S), and Family (F). (The range of scores is 0 to 30 with higher scores indicating better quality of life.) RESULTS: The mean (standard deviation; SD) of the overall QLI was 22.8 (4.0). The mean (SD) of the four subscales were as follows: H&F – 21.1 (4.7); S&E – 22.0 (4.8); P&S – 24.5 (4.4); and, F – 26.8 (3.5). H&F (r(s )= -0.326, p = 0.013) and F (r(s )= -0.248, p = 0.048) subscale scores were negatively correlated with periodic limb movement index but not other polysomnographic measures. The H&F subscale score were positively correlated with nocturnal sleep latency (r(s )= 0.248, p = 0.048) while the H&F (r(s )= 0.278, p = 0.030) and total QLI (r(s )= 0.263, p = 0.038) scores were positively associated with MSLT scores. Both of these latter findings indicate that higher life quality is associated with lower sleepiness levels. ESS scores were unrelated to overall QLI scores or the subscale scores. Subjective reports of difficulty falling asleep and waking up too early were significantly correlated with all four subscale scores and overall QLI. Feeling rested in the morning was positively associated with S&E, P&S, and Total QLI scores. CONCLUSION: Selected measures of both poor nocturnal sleep and increased daytime sleepiness are associated with decreased quality of life in HD patients, underscoring the importance of recognizing and treating these patients' sleep problems
Probing the Circumgalactic Medium at High-Redshift Using Composite BOSS Spectra of Strong Lyman-alpha Forest Absorbers
We present composite spectra constructed from a sample of 242,150 Lyman-alpha
(Lya) forest absorbers at redshifts 2.4<z<3.1 identified in quasar spectra from
the Baryon Oscillation Spectroscopic Survey (BOSS) as part of Data Release 9 of
the Sloan Digital Sky Survey III. We select forest absorbers by their flux in
bins 138 km/s wide (approximately the size of the BOSS resolution element). We
split these absorbers into five samples spanning the range of flux -0.05 <
F<0.45. Tests on a smaller sample of high-resolution spectra show that our
three strongest absorption bins would probe circumgalactic regions (projected
separation < 300 proper kpc and |Delta v| < 300km/s) in about 60% of cases for
very high signal-to-noise ratio. Within this subset, weakening Lya absorption
is associated with decreasing purity of circumgalactic selection once BOSS
noise is included. Our weaker two Lya absorption samples are dominated by the
intergalactic medium.
We present composite spectra of these samples and a catalogue of measured
absorption features from HI and 13 metal ionization species, all of which we
make available to the community. We compare measurements of seven Lyman series
transitions in our composite spectra to single line models and obtain further
constraints from their associated excess Lyman limit opacity. This analysis
provides results consistent with column densities over the range 14.4 <~ Log
(N_HI) <~ 16.45. We compare our measurements of metal absorption to a variety
of simple single-line, single-phase models for a preliminary interpretation.
Our results imply clumping on scales down to ~30 pc and near-solar
metallicities in the circumgalactic samples, while high-ionization metal
absorption consistent with typical IGM densities and metallicities is visible
in all samples.Comment: 23 pages, 15 figures, 5 tables, link to downloadable data included.
Accepted by MNRAS 2014 March 20. New sections 3.4 and 6.1 limiting the
occurrence and impact of Lyman limit system
Benchmarking image codecs by assessment of coded test images: the development of test images and new objective quality metrics, Journal of Telecommunications and Information Technology, 2006, nr 1
Objective quality measures are required for benchmarking codec performance. Our aim was to develop a simple, accurate method capable of rapidly measuring the degree of blockiness, edge-blur and ringing due to image compression. Two test images were designed to emphasise these artefacts. The efficacy of the new metrics is demonstrated using a JPEG codec at a range of compression levels
Implementing an electronic sideband offset lock for precision spectroscopy in radium
We demonstrate laser frequency stabilization with at least 6 GHz of offset
tunability using an in-phase/quadrature (IQ) modulator to generate electronic
sidebands (ESB) on a titanium sapphire laser at 714 nm and we apply this
technique to the precision spectroscopy of Ra, and Ra. By
locking the laser to a single resonance of a high finesse optical cavity and
adjusting the lock offset, we determine the frequency difference between the
magneto-optical trap (MOT) transitions in the two isotopes to be
MHz, a factor of 29 more precise than the previously available data. Using the
known value of the hyperfine splitting of the level, we calculate
the isotope shift for the to transition to be
MHz, which is a factor of 8 more precise than the best available
value. Our technique could be applied to countless other atomic systems to
provide unprecedented precision in isotope shift spectroscopy and other
relative frequency comparisons
Baryon Acoustic Oscillations in the Ly{\alpha} forest of BOSS DR11 quasars
We report a detection of the baryon acoustic oscillation (BAO) feature in the
flux-correlation function of the Ly{\alpha} forest of high-redshift quasars
with a statistical significance of five standard deviations. The study uses
137,562 quasars in the redshift range from the Data Release
11 (DR11) of the Baryon Oscillation Spectroscopic Survey (BOSS) of SDSS-III.
This sample contains three times the number of quasars used in previous
studies. The measured position of the BAO peak determines the angular distance,
and expansion rate, , both on a scale set by the sound
horizon at the drag epoch, . We find
and
where . The optimal
combination, is determined with a precision of
. For the value , consistent with the CMB power
spectrum measured by Planck, we find
and . Tests with mock
catalogs and variations of our analysis procedure have revealed no systematic
uncertainties comparable to our statistical errors. Our results agree with the
previously reported BAO measurement at the same redshift using the
quasar-Ly{\alpha} forest cross-correlation. The auto-correlation and
cross-correlation approaches are complementary because of the quite different
impact of redshift-space distortion on the two measurements. The combined
constraints from the two correlation functions imply values of and
that are, respectively, 7% low and 7% high compared to the
predictions of a flat CDM cosmological model with the best-fit Planck
parameters. With our estimated statistical errors, the significance of this
discrepancy is .Comment: Accepted for publication in A&A. 17 pages, 18 figure
Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features
Background: The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral infections. These effector functions confer cellular responses through engagement with innate immune cells. The precise mechanism(s) by which immunoglobulin G (IgG) Fc domain and cognate receptors may afford protection are poorly understood, however, in the context of HIV/SHIV infections. Many different in vitro assays have been developed and utilized to measure effector functions, but the extent to which these assays capture distinct antibody activities has not been fully elucidated. Results: In this study, six Fc-mediated effector function assays and two biophysical antibody profiling assays were performed on a common set of samples from HIV-1 infected and vaccinated subjects. Biophysical antibody profiles supported robust prediction of diverse IgG effector functions across distinct Fc-mediated effector function assays. While a number of assays showed correlated activities, supervised machine learning models indicated unique antibody features as primary contributing factors to the associated effector functions. Additional experiments established the mechanistic relevance of relationships discovered using this unbiased approach. Conclusions: In sum, this study provides better resolution on the diversity and complexity of effector function assays, offering a clearer perspective into this family of antibody mechanisms of action to inform future HIV-1 treatment and vaccination strategies
Recommendations of Common Data Elements to Advance the Science of Selfâ Management of Chronic Conditions
PurposeCommon data elements (CDEs) are increasingly being used by researchers to promote data sharing across studies. The purposes of this article are to (a) describe the theoretical, conceptual, and definition issues in the development of a set of CDEs for research addressing selfâ management of chronic conditions; (b) propose an initial set of CDEs and their measures to advance the science of selfâ management; and (c) recommend implications for future research and dissemination.Design and MethodsBetween July 2014 and December 2015 the directors of the National Institute of Nursing Research (NINR)â funded P20 and P30 centers of excellence and NINR staff met in a series of telephone calls and a faceâ toâ face NINRâ sponsored meeting to select a set of recommended CDEs to be used in selfâ management research. A list of potential CDEs was developed from examination of common constructs in current selfâ management frameworks, as well as identification of variables frequently used in studies conducted in the centers of excellence.FindingsThe recommended CDEs include measures of three selfâ management processes: activation, selfâ regulation, and selfâ efficacy for managing chronic conditions, and one measure of a selfâ management outcome, global health.ConclusionsThe selfâ management of chronic conditions, which encompasses a considerable number of processes, behaviors, and outcomes across a broad range of chronic conditions, presents several challenges in the identification of a parsimonious set of CDEs. This initial list of recommended CDEs for use in selfâ management research is provisional in that it is expected that over time it will be refined. Comment and recommended revisions are sought from the research and practice communities.Clinical RelevanceThe use of CDEs can facilitate generalizability of research findings across diverse population and interventions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134268/1/jnu12233_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134268/2/jnu12233.pd
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