Suppressed Ion Migration in Low-Dimensional Perovskites

Ion migration, which occurs in regular three-dimensional perovskites, is shown to be suppressed in low-dimensional perovskites both in the dark and under illumination, an indication of better stability of these materials for solar cells and light-emitting diodes

Analysis of genetic diversity and construction of core collection of local mulberry varieties from Shanxi Province based on ISSR marker

Genetic diversity of 73 local mulberry varieties from Shanxi Province were screened using ISSR markers, with l5 primers combinations selected for their reproducibility and polymorphism. 129 bands were amplified, of which 115 bands showed polymorphism and the ratio of polymorphism bands was 89.15%. Nei’s genetic similarity coefficients ranged from 0.5891 to 0.9457 with an average of 0.7674. The observed number of alleles of each loci, effective number of alleles of each loci, Nei’s gene diversity, Shannon’s information index were 1.8915, 1.4771, 0.2780 and 0.4197, respectively. Clustering results showed that the 73 varieties could be divided into three different groups and nine subgroups. By using stepwise clustering and random methods and the modified heuristic algorithm, 21 core collections were constructed and the ratio of core collection was 28.77%. The result of t-test to the parameters (the number effective of alleles, Nei's genetic diversity index and Shannon's information index) showed that there was not significant difference between the core collection and initial sample with the exception of the number of observed alleles, that is, the core collection could well represent the initial sample.Key words: Mulberry, germplasm resource, genetic diversity, ISSR, cluster analysis, core collection

A regulatory network for human adenocarcinoma

Human adenocarcinoma (AC) is the most frequently diagnosed human lung cancer and its absolute incidence is increasing dramatically. Our study aimed to interpret the mechanisms of human adenocarcinoma through the  regulation network based on differentially expressed genes (DEGs). We used the GSE2514 microarray data to identify human adenocarcinoma differentially expressed genes. Based on these genes and collected regulation datasets, 129 relationships between transcription factor and their target genes were established in AC. Finally, we find some new candidates and relationships, such as IL6 and NFKB1 owning a close connection with AC. Based on a relatively small number of patients, the results will need to be repeated and confirmed in future studies.Key words: Adenocarcinoma, transcription factors, transcriptome

On the existence and uniqueness of solutions to stochastic differential equations driven by G-Brownian motion with integral-Lipschitz coefficients

In this paper, we study the existence and uniqueness of solutions to stochastic differential equations driven by G-Brownian motion (GSDEs) with integral-Lipschitz conditions on their coefficients

Visualization study on the heat and mass transfer in the evaporator-compensation chamber of a loop heat pipe

To visually analyze the flow and heat transfer characteristics of the working fluid in a loop heat pipe (LHP), the evaporator-compensation chamber (CC) was designed as a half-sectioned cylindrical structure sealed with a glass window. Using acetone as the working fluid, visualization experiments were performed under different heat loads and tilt angles. The vapour-liquid distribution in the evaporator-CC coupling structure and the temperature variation characteristics of the LHP system were investigated at three tilt angles of the evaporator-CC coupling structure. According to the experimental results including the startup and steady-state operation, some important conclusions have been drawn as summarized below: (1) with the subcooled liquid outflow from the bayonet tube, the vapour-liquid interface in the evaporator-CC coupling structure rises when the heat load is applied to the evaporator; (2) the bubble generation inside the porous wick becomes more intense with an increased heat load, and there are various bubble movement patterns at different tilt angles; (3) the temperature fluctuation of the LHP system is closely related to the oscillation of the vapour-liquid interface in the evaporator core

Dynamics aspect of subbarrier fusion reaction in light heavy ion systems

Subbarrier fusion of the 7Li + 12C reaction is studied using an antisymmetrized molecular dynamics model (AMD) with an after burner, GEMINI. In AMD, 7Li shows an \alpha + t structure at its ground state and it is significantly deformed. Simulations are made near the Coulomb barrier energies, i.e., E_{cm} = 3 - 8 MeV. The total fusion cross section of the AMD + GEMINI calculations as a function of incident energy is compared to the experimental results and both are in good agreement at E_{cm} > 3 MeV. The cross section for the different residue channels of the AMD + GEMINI at E_{cm} = 5 MeV is also compared to the experimental results.Comment: Talk given by Meirong Huang at the 11th International Conference on Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1, 2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference Series (JPCS

Power and sample size for dose-finding studies with survival endpoints under model uncertainty

Multiple comparison procedures combined with modeling techniques (MCP-Mod) (Bretz et al., 2005) is an efficient and robust statistical methodology for the model-based design and analysis of dose-finding studies with an unknown dose–response model. With this approach, multiple comparison methods are used to identify statistically significant contrasts corresponding to a set of candidate dose–response models, and the best model is then used to estimate the target dose. Power and sample size calculations for this methodology require knowledge of the covariance matrix for the estimators of the (placebo-adjusted) mean responses among the dose groups. In this article, we consider survival endpoints and derive an analytic form of the covariance matrix for the estimators of the log hazard ratios as a function of the total number of events in the study. We then use this closed-form expression of the covariance matrix to derive the power and sample size formulas. We discuss practical considerations in the application of these formulas. In addition, we provide an illustration with a motivating example on chronic obstructive pulmonary disease. Finally, we demonstrate through simulation studies that the proposed formulas are accurate enough for practical use. © 2018, The International Biometric Societ

Effect of WeiJia on carbon tetrachloride induced chronic liver injury

Aim: To study the effect of WeiJia on chronic liver injury using carbon tetrachloride (CCl 4) induced liver injury animal model. Methods: Wista r rats weighing 180-220g were randomly divided into three groups: normal control group (Group A), CCl 4 induced liver injury control group (Group B) and CCl 4 induction with WeiJia treatment group (Group C). Each group consisted of 14 rats. Liver damage and fibrosis was induced by subcutaneous injection with 40% CCl 4 in olive oil at 3 mL/kg body weight twice a week for eight weeks for Groups B and C rats whereas olive oil was used for Group A rats. Starting from the third week, Group C rats also received daily intraperitoneal injection of WeiJia at a dose of 1.25 μg/kg body weight. Animals were sacrificed at the fifth week (4 male, 3 female), and eighth week (4 male, 3 female) respectively. Degree of fibrosis were measured and serological markers for liver fibrosis and function including hyaluronic acid (HA), type IV collagen (CIV), γ-glutamyl transferase (γ-GT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. Alpha smooth muscle actin (α-SMA) and proliferating cell nuclear antigen (PCNA) immunohistochemistry were also performed. Results: CCl 4 induction led to the damage of liver and development of fibrosis in Group B and Group C rats when compared to Group A rats. The treatment of WeiJia in Group C rats could reduce the fibrosis condition significantly compared to Group B rats. The effect could be observed after three weeks of treatment and was more obvious after eight weeks of treatment. Serum HA, CIV, ALT, AST and γ-GT levels after eight weeks of treatment for Group C rats were 58±22 μg/L (P 0.05) respectively, similar to normal control group (Group A), but significantly different from CCl 4 induced liver injury control group (Group B). An increase in PCNA and decrease in α-SMA expression level was also observed. Conclusion: WeiJia could improve liver function and reduce liver fibrosis which might be through the inhibition of stellate cell activity. © 2006 The WJG Press. All rights reserved.published_or_final_versio