Закономерности изменения параметров процесса фильтрации воды при подработке обводненых пород

Разработана математическая модель фильтрации воды в деформируемом массиве горных пород. Впервые анкерная крепь рассмотрена как технологический способ снижения водопритока в горную выработку. Приведенными расчетами показано, что анкерная крепь может одновременно выполнять две функции: обеспечения устойчивости выработки и ее гидроизоляции, что существенно снижает расходы на поддержание выработки. На основании полученных результатов разработан «Способ снижения водопритока в горную выработку с применением анкерного крепления»

Proceedings of the 23th Bilateral Student Workshop CTU Prague: Dresden (Germany) 2019

This technical report publishes the proceedings of the 23th Prague Workshop, which was held from 29th to 30th November 2019. The workshop offers a possibility for young scientists to present their current research work in the fields of computer graphics, human-computer-interaction, robotics and usability. The works is meant as a platform to bring together researchers from both the Czech Technical University in Prague (CTU) and the University of Applied Sciences Dresden (HTW). The German Academic Exchange Service offers its financial support to allow student participants the bilateral exchange between Prague and Dresden.:1) Incremental Pose Estimation of multiple LiDAR Scanners using their Pointclouds, S.3 2) Soft- and Hardware Developments for Immersive Learning, S.6 3) Qualitative comparison of methods for example-based style transfer, S.13 4) External Labeling With Utilization of Containment Information, S.16 5) Real Time Viewing Direction Analysis to Store Recognized Faces, S.20 6) Raising living standards of older adults - User research, S.29 7) Raising living standards of older adults - Concept, S.33 8) Towards the RoNiSCo Mobile Application, S.36 9) Development of a Fallen People Detector, S.41 10) Interactive tactile map for visually impaired older adults, S.47 11) Physical 3D LED display, S.5

24th Bilateral Student Workshop CTU Prague and HTW Dresden - User Interfaces & Visualization

This technical report publishes the proceedings of the 24th Bilateral Student Workshop CTU Prague and HTW Dresden -User Interfaces & Visualization-, which was held on the 26th November 2021. The workshop offers a possibility for young scientists to present their current research work in the fields of computer graphics, human-computer-interaction, robotics and usability. The works is meant as a platform to bring together researchers from both the Czech Technical University in Prague (CTU) and the University of Applied Sciences Dresden (HTW). The German Academic Exchange Service offers its financial support to allow student participants the bilateral exchange between Prague and Dresden.:1) Robot assisted reminiscence therapy for people with dementia, p.4 2) VENT-CONECT: System for remote monitoring of instruments used in intensive care, p.12 3) Conversational assistant for smart home, p.17 4) Perspectives and challenges of the research project ”SYNC ID” , p.23 5) Music-based emotional biofeedback: the state of the art and challenges, p.26 6) Ambient Assisted Living Lab - Smart Systems and CoCreation, p.30 7) Board Game Playing and Consuming Beverages in VR, p.36 8) An approach to measure and increase the level of participation of people with dementia in cognitive games, p.41 9) Forced perspective illusions and scaling users in VR - state of the art., p.47 10) Training Deep Learning Models for Punctuation Prediction, p.51 11) Towards an Evaluation of Ambiguity in Point-Feature Labelling, p.56 12) The ReZA method goes digital, p.60 13) Haptic interface for spatial audio web player, p.6

High-sensitivity troponin assays in the evaluation of patients with acute chest pain in the emergency department

Evaluating patients with acute chest pain presenting to the emergency department remains an ongoing challenge. The spectrum of etiologies in acute chest pain ranges from minor disease entities to life-threatening diseases, such as pulmonary embolism, acute aortic dissection or acute myocardial infarction (MI). The diagnosis of acute MI is usually made integrating the triad of patient history and clinical presentation, readings of 12-lead ECG and measurement of cardiac troponins (cTn). Introduction of high-sensitivity cTn assays substantially increases sensitivity to identify patients with acute MI even at the time of presentation to the emergency department at the cost of specificity. However, the proportion of patients presenting with cTn positive, non-vascular cardiac chest pain triples with the implementation of new sensitive cTn assays increasing the difficulty for the emergency physician to identify those patients who are at need for invasive diagnostics. The main objectives of this mini-review are 1) to discuss elements of disposition decision made by the emergency physician for the evaluation of chest pain patients, 2) to summarize recent advances in assay technology and relate these findings into the clinical context, and 3) to discuss possible consequences for the clinical work and suggest an algorithm for the clinical evaluation of chest pain patients in the emergency departmen

Dose-Related Effects of ACE Inhibition in Man: Quinapril in Patients with Moderate Congestive Heart Failure

Early treatment with ACE inhibitors of even moderate heart failure is clinically beneficial, even though haemodynamic measurements cannot adequately quantitate such improvement. Neurohumoral assessment is, however, supposed to be more accurate In 55 patients with moderate heart failure (ejection fraction ≤ 35%), we investigated the dose-dependent effects of ACE inhibition with quinapril taken orally (2.5, 5 or 10 mg b.i.d.) following a placebo-controlled, parallel design protocol over 12 weeks. Plasma components of the renin angiotensin system, catecholamines and ANF were measured together with haemodymmics both at rest and during exercise. Before ACE inhibitor treatment, median PRA, Ang I and II and catecholamines were normal, while ANF was increased All these parameters including ACE activity, rose during exercise. Chronic inhibition of ACE activity was dose-dependent and the maximal fall in Ang If occurred with quinapril 20 mg.day−1. Humoral changes appeared more assessible than haemodymmic alterations even though many of these changes were reasonably correlated. The effects of chronic ACE inhibition on circulating neurohumoral components in patients with moderate heart failure are small and dose-dependent. Since humoral changes are related to haemodynamics they should account for the clinical benefit. Appropriately high doses of ACE inhibitors should be chosen for treatment of heart failur

SPMSQ for risk stratification of older patients in the emergency department : An exploratory prospective cohort study

Risk stratification of older patients in the emergency department (ED) is seen as a promising and efficient solution for handling the increase in demand for geriatric emergency medicine. Previously, the predictive validity of commonly used tools for risk stratification, such as the identification of seniors at risk (ISAR), have found only limited evidence in German geriatric patient samples. Given that the adverse outcomes in question, such as rehospitalization, nursing home admission and mortality, are substantially associated with cognitive impairment, the potential of the short portable mental status questionnaire (SPMSQ) as a tool for risk stratification of older ED patients was investigated

Of “raisins” and “yeast”: mobilisation and framing in the East German revolution of 1989

There is no shortage of literature on the social movements that arose in East Germany in 1989. Numerous studies have shed light upon the nature, scale and dynamics of the uprising of that year. But on certain issues questions remain. No consensus exists, for example, on the relationship between the “civic groups” (New Forum, Democratic Awakening, etc.) and the street protests of the autumn of 1989. Were these simply two facets of a single movement? Or are they better characterised as two distinct streams within the same movement delta? Did the street protests push the civic movement activists into the limelight? Or is it more accurate to say, with Reinfried Musch, that “the civic movement brought the people onto the streets”?1 This paper considers two contrasting interpretations of these issues, and finds both wanting. An alternative interpretation is offered, one that draws upon Marc Steinberg's “dialogical” development of frame theory

Enzyme Activity by Design: An Artificial Rhodium Hydroformylase for Linear Aldehydes

Funding: Marie Curie Individual Fellowship project ArtOxiZymes to AGJ (contract no. H2020-MSCA-IF-2014-657755), EPSRC Critical mass grant ‘Clean catalysis for sustainable development’ (EP/J018139/1) and Sasol (CASE studentship to P.J.D.), EPSRC (EP/K014854/1).Artificial metalloenzymes (ArMs) are hybrid catalysts that offer a unique opportunity to combine the superior performance of natural protein structures with the unnatural reactivity of transition-metal catalytic centers. Therefore, they provide the prospect of highly selective and active catalytic chemical conversions for which natural enzymes are unavailable. Herein, we show how by rationally combining robust site-specific phosphine bioconjugation methods and a lipid-binding protein (SCP-2L), an artificial rhodium hydroformylase was developed that displays remarkable activities and selectivities for the biphasic production of long-chain linear aldehydes under benign aqueous conditions. Overall, this study demonstrates that judiciously chosen protein-binding scaffolds can be adapted to obtain metalloenzymes that provide the reactivity of the introduced metal center combined with specifically intended product selectivity.Publisher PDFPeer reviewe

Dose-related effects of ACE inhibition in man: quinapril in patients with moderate congestive heart failure. The Study Group on Neurohormonal Regulation in Congestive Heart Failure: Lausanne, Switzerland; Berlin, Dusseldorf, Munich, Germany

Early treatment with ACE inhibitors of even moderate heart failure is clinically beneficial, even though haemodynamic measurements cannot adequately quantitate such improvement. Neurohumoral assessment is, however, supposed to be more accurate. In 55 patients with moderate heart failure (ejection fraction < or = 35%), we investigated the dose-dependent effects of ACE inhibition with quinapril taken orally (2.5, 5 or 10 mg b.i.d.) following a placebo-controlled, parallel design protocol over 12 weeks. Plasma components of the renin angiotensin system, catecholamines and ANF were measured together with haemodynamics both at rest and during exercise. Before ACE inhibitor treatment, median PRA, Ang I and II and catecholamines were normal, while ANF was increased. All these parameters, including ACE activity, rose during exercise. Chronic inhibition of ACE activity was dose-dependent and the maximal fall in Ang II occurred with quinapril 20 mg.day-1. Humoral changes appeared more assessible than haemodynamic alterations even though many of these changes were reasonably correlated. The effects of chronic ACE inhibition on circulating neurohumoral components in patients with moderate heart failure are small and dose-dependent. Since humoral changes are related to haemodynamics they should account for the clinical benefit. Appropriately high doses of ACE inhibitors should be chosen for treatment of heart failure