Misuse of Diagnostic Aids in Process Control: The Effects of Automation Misses on Complacency and Automation Bias

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.The effects of misses of an automated alarm and fault diagnosis system on different manifestations of automation misuse were examined. 24 participants operated a complex multi-task process control simulation. During training, they either experienced automation misses or were only informed that failures might occur. The experience of misses reduced complacency towards the alarm function of the decision aid as well as omission errors but did neither affect complacency towards the aid's diagnostic function nor commission errors. Implications of this specific effect of automation misses for the design of training measures as well as the theoretical understanding of automation misuse are discussed

Automation in Surgery: The Surgeons' Perspective on Human Factors Issues of Image-Guided Navigation

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.Image-guided navigation (IGN) systems support the surgeon in navigating through the patients' anatomy. Previous research on IGN has focused on technical feasibility and clinical applications. Yet, as the introduction of IGN corresponds to a partial automation of the surgeon's task, well known issues of human-automation interaction might play a crucial role for the success of IGN as well. The present study represents a first attempt to assess the impact of IGN on four key issues of human automation-interaction, i.e., workload, situation awareness, trust, and skill degradation, from the surgeons' perspective. A nation-wide survey among 213 German surgeons from 94 different hospitals was conducted. Results revealed (1) a workload-shift due to IGN rather than a reduction of workload, (2) benefits of IGN with respect to situation awareness, (3) comparatively high levels of perceived reliability, trust and reliance, and (4) skill degradation as a possible risk, albeit only for inexperienced surgeons

Current Concepts and Trends in Human-Automation Interaction

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.The purpose of this panel was to provide a general overview and discussion of some of the most current and controversial concepts and trends in human-automation interaction. The panel was composed of eight researchers and practitioners. The panelists are well-known experts in the area and offered differing views on a variety of different human-automation topics. The range of concepts and trends discussed in this panel include: general taxonomies regarding stages and levels of automation and function allocation, individualized adaptive automation, automation-induced complacency, economic rationality and the use of automation, the potential utility of false alarms, the influence of different types of false alarms on trust and reliance, and a system-wide theory of trust in multiple automated aids

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin

Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels. This holds true for protective antigen (PA), the binding component of the tripartite anthrax-toxin of Bacillus anthracis. Evidence has been presented that translocation of the enzymatic components of anthrax-toxin across the endosomal membrane of target cells and channel formation by the heptameric/octameric PA63 binding/translocation component are related phenomena. Chloroquine and some 4-aminoquinolones, known as potent drugs against Plasmodium falciparium infection of humans, block efficiently the PA63-channel in a dose dependent way.Methodology/Principal Findings:Here we demonstrate that related positively charged heterocyclic azolopyridinium salts block the PA63-channel in the μM range, when both, inhibitor and PA63 are added to the same side of the membrane, the cis-side, which corresponds to the lumen of acidified endosomal vesicles of target cells. Noise-analysis allowed the study of the kinetics of the plug formation by the heterocycles. In vivo experiments using J774A.1 macrophages demonstrated that the inhibitors of PA63-channel function also efficiently block intoxication of the cells by the combination lethal factor and PA63 in the same concentration range as they block the channels in vitro.Conclusions/Significance:These results strongly argue in favor of a transport of lethal factor through the PA63-channel and suggest that the heterocycles used in this study could represent attractive candidates for development of novel therapeutic strategies against anthrax. © 2013 Beitzinger et al

Galactic clusters with associated Cepheid variables. VII. Berkeley 58 and CG Cassiopeiae

Photoelectric, photographic, and CCD UBV photometry, spectroscopic observations, and star counts are presented for the open cluster Berkeley 58 to examine a possible association with the 4.37d Cepheid CG Cas. The cluster is difficult to separate from the early-type stars belonging to the Perseus spiral arm, in which it is located, but has reasonably well-defined parameters: an evolutionary age of ~10^8 years, a mean reddening of E(B-V)_(B0)=0.70+-0.03 s.e., and a distance of 3.03+-0.17 kpc (V_0-M_V=12.40+-0.12 s.d.). CG Cas is a likely cluster coronal member on the basis of radial velocity, and its period increase of +0.170+-0.014 s yr^(-1) and large light amplitude describe a Cepheid in the third crossing of the instability strip lying slightly blueward of strip centre. Its inferred reddening and luminosity are E(B-V)=0.64+-0.02 s.e. and =-3.06+-0.12. A possible K supergiant may also be a cluster member.Comment: Accepted for Publication (MNRAS

Perspectives of Portuguese People with Physical Disabilities Regarding Their Sexual Health: A Focus Group Study

The World Health Organization has considered sexual health as a major dimension of global health and a sexual right. However, the sexual health of people with physical disabilities is still poorly addressed by health and social care professionals, and it is very stigmatized by society. This study aimed to assess the perspectives of Portuguese people living with physical disabilities regarding issues affecting their sexual health. Nine women and 17 men with different physical disabilities participated in the study. Participants were recruited from a professional rehabilitation facility located in the North of Portugal and were assigned to four groups in one-hour sessions. Three main categories emerged from the content analysis: (1) meanings and beliefs regarding sexuality; (2) experiences of sexuality; (3) necessary changes. Despite the positive social changes towards sexuality, participants expressed that their sexual rights are still unfulfilled, as they live in a context that perpetuates their dependency. They pointed out low self-esteem, prejudice and social isolation, poor architectural accessibility and scarcity of financial support as some of the barriers to their lives and their sexual health. Finally, participants identified the main needs regarding their sexual health, such as: access to specialized information; training for health professionals. This study gives voice to people with physical disabilities and sheds light into both individual and contextual factors affecting their sexual health. Of utmost importance, this study draws attention to the need for reinforcing sexuality of people with disabilities in the social agenda and brings implications for future research and practice.This study was supported by a Grant attributed to the first author by the Portuguese Foundation for Science and Technology (SFRH/BD/112168/2015)info:eu-repo/semantics/publishedVersio

Dopamine Beta Hydroxylase Genotype Identifies Individuals Less Susceptible to Bias in Computer-Assisted Decision Making

Computerized aiding systems can assist human decision makers in complex tasks but can impair performance when they provide incorrect advice that humans erroneously follow, a phenomenon known as “automation bias.” The extent to which people exhibit automation bias varies significantly and may reflect inter-individual variation in the capacity of working memory and the efficiency of executive function, both of which are highly heritable and under dopaminergic and noradrenergic control in prefrontal cortex. The dopamine beta hydroxylase (DBH) gene is thought to regulate the differential availability of dopamine and norepinephrine in prefrontal cortex. We therefore examined decision-making performance under imperfect computer aiding in 100 participants performing a simulated command and control task. Based on two single nucleotide polymorphism (SNPs) of the DBH gene, −1041 C/T (rs1611115) and 444 G/A (rs1108580), participants were divided into groups of low and high DBH enzyme activity, where low enzyme activity is associated with greater dopamine relative to norepinephrine levels in cortex. Compared to those in the high DBH enzyme activity group, individuals in the low DBH enzyme activity group were more accurate and speedier in their decisions when incorrect advice was given and verified automation recommendations more frequently. These results indicate that a gene that regulates relative prefrontal cortex dopamine availability, DBH, can identify those individuals who are less susceptible to bias in using computerized decision-aiding systems