Effect of low concentrations of antibiotic intracanal medicaments on crown discoloration and push-out bond strength

Indiana University-Purdue University Indianapolis (IUPUI)Introduction: Some intracanal medicaments used in regenerative endodontics may compromise the bond strength of root cements and lead to tooth discoloration. Objectives: To evaluate the effects of 1) low concentrations of TAP and DAP (1 mg/mL) on push-out bond strength of various root cements, and 2) low concentrations of TAP and DAP (1 mg/mL and 10 mg/mL) on crown discoloration. Materials and Methods: Single rooted human teeth (n = 144) were horizontally decoronated and instrumented according to standardized protocol. The samples were randomized into six experimental groups (Ca(OH)2, 1000 mg/mL TAP and DAP, 1 mg/mL TAP and DAP, and no medicament control group. After four weeks, the medicaments were removed and each group was divided into three subgroups to receive MTA cement, Biodentine cement, or Endosequence Bioceramic putty cement for two weeks. Then, two root cylinders were obtained from each root and push-out bond strength testing was performed. For the crown discoloration experiment, 160 crowns were obtained from intact human molars and randomized into experimental groups as described earlier with the addition of two groups (10 mg/mL TAP and DAP). The pulp chambers in half of the samples from each group were coated with an adhesive bonding agent before receiving the assigned intracanal medicament. Color changes (ΔE) were detected by spectrophotometer at 1 day, 1 week, and 4 weeks after application, as well as after thermocycling. Results: In the push-out bond strength experiment, 1 mg/mL DAP generally demonstrated significantly higher bond strength of root cements compared with the other treatment groups. For the crown discoloration experiment, when an adhesive bonding agent was used prior to (10 mg/mL or 1000 mg/mL) TAP, the crowns had significantly less discoloration than those without adhesive. DAP 10 mg/mL had the least significant color change at all time points regardless of whether adhesive was used. Conclusion: 1) 1 mg/mL DAP and Ca(OH)2 did not have significant negative effect on the bond strength of calcium-silicate-based cement to radicular dentin. 2) 1 mg/mL and 10 mg/mL of DAP and Ca(OH)2 had significantly less effect on the color change of the human tooth crown than all intracanal medicaments used in this study.2020-08-1

Quality of Life and its Relation to Self-Esteem for a Sample of Drugs Addicts

The study aimed to identify the quality of life and its relation to self-esteem for a sample of drug addicts, as well as the differences between returning to addiction once and returning to addiction more than once in these variables. The study sample consisted of 70 male drug addicts using tramadol, cannabis, and alcohol who frequented the drug treatment center of the anti-narcotics program in Jordan. Two scales were used to assess the quality of life and self- esteem. The study results showed a significant correlation between quality of life and self-esteem. Moreover, the results showed that there were statistically significant differences between the means of drug addicts in favor of addiction once and those returning to addiction more than once in both quality of life and self-esteem for the drug addicts returning to addiction once

Inner Child, Self-Esteem, and Mental Health in Jordanian University Students

The study investigated the influence of the inner child on the mental health of Jordanian university students, considering the mediating role of self-esteem. Using a descriptive analytical survey method, a simple random sample of 625 Jordanian university students was utilized. The study employed three scales: the inner child scale (18 items), the mental health scale (15 items), and the Rosenberg self-esteem scale (10 items). Findings revealed that Jordanian university students demonstrated a high level of awareness of their inner child, mental health, and self-esteem. Statistical analysis indicated no significant differences (α ≤ 0.05) in the impact of inner child awareness on the mental health of Jordanian university students, considering the mediating role of self-esteem, based on variables such as sex, college, and educational level. Moreover, the study identified a positive correlation between inner child awareness and mental health, as well as a positive association between self-esteem and mental health. Consequently, the study recommends several actions, including conducting a longitudinal study to explore the impact of the inner child across various life stages (childhood, adolescence, youth, and old age)

Hybrid Information Hiding Technique Using Parametric Spline and DFT

Information hiding is a means to conical and transmitting information usingapparently innocent carrier without depiction any suspicions. This paper presents anew means for information hiding based images by using Hybrid of ParametricSpline and DFT. A set of control points, which represents secret key, are selectsrandomly from the carrier , and a curve pass by the selected control points isimplement using B-Spline. A hiding process for the secret message bits tacksplace on the spectral real part of the intensity pixels where the B-Spline curvepasses by using LSB technique, followed by the IDFT. The paper also presents theinformation hiding features, and techniques for images, and Interpolationtechniques. The Objective fidelity criteria are depicts the improvements inalgorithm with an application example

Alloimmunization is associated with older age of transfused red blood cells in sickle cell disease

Red blood cell (RBC) alloimmunization is a significant clinical complication of sickle cell disease (SCD). It can lead to difficulty with cross-matching for future transfusions and may sometimes trigger life-threatening delayed hemolytic transfusion reactions. We conducted a retrospective study to explore the association of clinical complications and age of RBC with alloimmunization in patients with SCD followed at a single institution from 2005 to 2012. One hundred and sixty six patients with a total of 488 RBC transfusions were evaluated. Nineteen patients (11%) developed new alloantibodies following blood transfusions during the period of review. The median age of RBC units was 20 days (interquartile range: 14-27 days). RBC antibody formation was significantly associated with the age of RBC units (P = 0.002), with a hazard ratio of 3.5 (95% CI: 1.71-7.11) for a RBC unit that was 7 days old and 9.8 (95% CI: 2.66-35.97) for a unit that was 35 days old, 28 days after the blood transfusion. No association was observed between RBC alloimmunization and acute vaso-occlusive complications. Although increased echocardiography-derived tricuspid regurgitant jet velocity (TRV) was associated with the presence of RBC alloantibodies (P = 0.02), TRV was not significantly associated with alloimmunization when adjusted for patient age and number of transfused RBC units. Our study suggests that RBC antibody formation is significantly associated with older age of RBCs at the time of transfusion. Prospective studies in patients with SCD are required to confirm this finding

Translating Research Into Practice: The Role of Provider-based Research Networks in the Diffusion of an Evidence-based Colon Cancer Treatment Innovation

Provider-based research networks (PBRNs) – collaborative research partnerships between academic centers and community-based practitioners – are a promising model for accelerating the translation of research into practice; however, empirical evidence of accelerated translation is limited. Oxaliplatin in adjuvant combination chemotherapy is an innovation with clinical trial-proven survival benefit compared to prior therapies. The goal of this study is to examine the diffusion of oxaliplatin into community practice, and whether affiliation with the National Cancer Institute’s (NCI’s) Community Clinical Oncology Program (CCOP) – a nationwide cancer-focused PBRN – is associated with accelerated innovation adoption

Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide

Atherosclerosis is promoted by a combination of hypercholesterolemia and vascular inflammation. The function of Angiopoietin (Ang)-2, a key regulator of angiogenesis, in the maintenance of large vessels is unknown. A single systemic administration of Ang-2 adenovirus (AdAng-2) to apoE-/- mice fed a Western diet significantly reduced atherosclerotic lesion size 8 40%) and oxidized LDL and macrophage content of the plaques. These beneficial effects were abolished by the inhibition of nitric oxide synthase (NOS). In endothelial cells, endothelial NOS activation per se inhibited LDL oxidation and Ang-2 stimulated NO release in a Tie2-dependent manner to decrease LDL oxidation. These findings demonstrate a novel atheroprotective role for Ang-2 when endothelial cell function is compromised and suggest that growth factors, which stimulate NO release without inducing inflammation, could offer atheroprotection

Diseño e implementación de un Sistema Interactivo de Video bajo Demanda

El proyecto que presentamos muestra el diseño e implementación de un sistema interactivo de vídeo bajo demanda, que nos servirá como base en el desarrollo de modelos válidos que nos permitan representar sistemas multimedia, a efectos de definir un entorno donde mediante técnicas de simulación avanzadas, podamos analizar y diseñar este tipo de sistemas. Es usual, al afrontar el diseño de este tipo de sistemas, orientar los esfuerzos únicamente, en una de las múltiples áreas que implican su resolución; nuestro objetivo integra el estudio del sistema en su conjunto: el software de sistema, la red de interconexión, el servidor de almacenamiento, servidor de procesamiento y el diseño/desarrollo del cliente. A partir de un subconjunto de las especificaciones que debe cumplir el sistema, construiremos una primera plataforma de pruebas e iremos diseñando y sintonizando los modelos en paralelo. La construcción de prototipos, monitorización y simulación, serán las herramientas que nos permitirán afrontar con garantías el proyecto que pretendemos asumirÁrea: Procesamiento de Imágenes - Tratamiento de Señales - Computación Gráfica - VisualizaciónRed de Universidades con Carreras en Informática (RedUNCI