Next-to-Leading Order NMSSM Decays with CP-odd Higgs Bosons and Stops

We compute the full next-to-leading order supersymmetric (SUSY) electroweak (EW) and SUSY-QCD corrections to the decays of CP-odd NMSSM Higgs bosons into stop pairs. In our numerical analysis we also present the decay of the heavier stop into the lighter stop and an NMSSM CP-odd Higgs boson. Both the EW and the SUSY-QCD corrections are found to be significant and have to be taken into account for a proper prediction of the decay widths.Comment: 28 pages, 10 figure

Differential Regulation of Dynamin-related Protein 1 Splice Variants by Membrane Adaptors

We begin the first biochemical examination of the multiple splice variants of human Dynamin-related protein 1 (Drp1), a GTPase involved in mitochondrial fission. While eight such variants, generated through alternative mRNA splicing, have been identified, here we focus on two: the shortest variant (Short) which is ubiquitous, and the longest (Long), which piqued our interest since Drp1 Long is expressed exclusively in neurons. We now establish the various functional differences between these two Drp1 splice variants. Our data reveal that whereas Drp1 Short exhibits constitutively high GTPase activity, Drp1 Long does not. Interestingly, mitochondrial outer membrane proteins, mitochondrial fission protein 1 (Fis1) and mitochondrial fission factor (Mff) that putatively function as receptors for Drp1 differentially regulate the enzymatic activity of the two splice variants. It is possible that the roles of Mff and Fis1, which have conflicting reports in the literature, may vary across Drp1 splice variants and thus be tissue specific. To gain a better understanding of the role of such Drp1 effectors, we focus primarily on Mff, as it has the strongest observed effect on Drp1 enzymatic activity, and probe its mechanism of action using a variety of biochemical and biophysical tools

The apparent excess in the Higgs to di-photon rate at the LHC: New Physics or QCD uncertainties?

The Higgs boson with a mass $M_H \approx 126$ GeV has been observed by the ATLAS and CMS experiments at the LHC and a total significance of about five standard deviations has been reported by both collaborations when the channels $H\to \gamma \gamma$ and $H\to ZZ \to 4\ell$ are combined. Nevertheless, while the rates in the later search channel appear to be in accord with those predicted in the Standard Model, there seems to be an excess of data in the case of the $H\to \gamma\gamma$ discovery channel. Before invoking new physics contributions to explain this excess in the di--photon Higgs rate, one should verify that standard QCD effects cannot account for it. We describe how the theoretical uncertainties in the Higgs boson cross section for the main production process at the LHC, $gg \to H$, which are known to be large, should be incorporated in practice. We further show that the discrepancy between the theoretical prediction and the measured value of the $gg \to H \to \gamma \gamma$ rate, reduces to about one standard deviation when the QCD uncertainties are taken into account.Comment: LaTeX, 2 figures, 9 pages. Final version published in Physics Letters B with minor typos correcte

The measurement of the Higgs self-coupling at the LHC: theoretical status

Now that the Higgs boson has been observed by the ATLAS and CMS experiments at the LHC, the next important step would be to measure accurately its properties to establish the details of the electroweak symmetry breaking mechanism. Among the measurements which need to be performed, the determination of the Higgs self-coupling in processes where the Higgs boson is produced in pairs is of utmost importance. In this paper, we discuss the various processes which allow for the measurement of the trilinear Higgs coupling: double Higgs production in the gluon fusion, vector boson fusion, double Higgs-strahlung and associated production with a top quark pair. We first evaluate the production cross sections for these processes at the LHC with center-of-mass energies ranging from the present $\sqrt s=8$ TeV to $\sqrt s=100$ TeV, and discuss their sensitivity to the trilinear Higgs coupling. We include the various higher order QCD radiative corrections, at next-to-leading order for gluon and vector boson fusion and at next-to-next-to-leading order for associated double Higgs production with a gauge boson. The theoretical uncertainties on these cross sections are estimated. Finally, we discuss the various channels which could allow for the detection of the double Higgs production signal at the LHC and the accuracy on the self-coupling that could be ultimately achieved.Comment: 37 pages, 10 tables, 17 figures. Typos corrected, matches the journal versio

Higgs Physics at the Large Hadron Collider

In this talk I will begin by summarising the importance of the Higgs physics studies at the LHC. I will then give a short description of the pre-LHC constraints on the Higgs mass and the theoretical predictions for the LHC along with a discussion of the current experimental results, ending with prospects in the near future at the LHC. In addition to the material covered in the presented talk, I have included in the writeup, a critical appraisal of the theoretical uncertainties in the Higgs cross-sections at the Tevatron as well as a discussion of the recent experimental results from the LHC which have become available since the time of the workshop.Comment: LateX, 12 figures, 15 pages, Presented at the XIth Workshop on High Energy Physics Phenomenology, 2010, Ahmedabad, Indi

The Tevatron Higgs exclusion limits and theoretical uncertainties: a critical appraisal

We examine the exclusion limits set by the CDF and D0 experiments on the Standard Model Higgs boson mass from their searches at the Tevatron in the light of large theoretical uncertainties on the signal and background cross sections. We show that when these uncertainties are consistently taken into account, the sensitivity of the experiments becomes significantly lower and the currently excluded mass range $M_H=158$-175 GeV would be entirely reopened. The necessary luminosity required to recover the current sensitivity is found to be a factor of two higher than the present one.Comment: 11 pages, 5 Figures. Version published in Physics Letter B, including an erratu

Bound-state/elementary-particle duality in the Higgs sector and the case for an excited 'Higgs' within the standard model

Though being weakly interacting, QED can support bound states. In principle, this can be expected for the weak interactions in the Higgs sector as well. In fact, it has been argued long ago that there should be a duality between bound states and the elementary particles in this sector, at least in leading order in an expansion in the Higgs condensate. Whether this remains true beyond the leading order is investigated using lattice simulations, and support is found. This provides a natural interpretation of peaks in cross sections as bound states. Unambiguously, this would imply the existence of (possibly very broad) resonances of Higgs and W and Z bound states within the standard model.Comment: 15 pages, 3 figures v2: added appendix with technical details, some minor improvement

Probing DNA conformational changes with high temporal resolution by Tethered Particle Motion

The Tethered Particle Motion (TPM) technique informs about conformational changes of DNA molecules, e.g. upon looping or interaction with proteins, by tracking the Brownian motion of a particle probe tethered to a surface by a single DNA molecule and detecting changes of its amplitude of movement. We discuss in this context the time resolution of TPM, which strongly depends on the particle-DNA complex relaxation time, i.e. the characteristic time it takes to explore its configuration space by diffusion. By comparing theory, simulations and experiments, we propose a calibration of TPM at the dynamical level: we analyze how the relaxation time grows with both DNA contour length (from 401 to 2080 base pairs) and particle radius (from 20 to 150~nm). Notably we demonstrate that, for a particle of radius 20~nm or less, the hydrodynamic friction induced by the particle and the surface does not significantly slow down the DNA. This enables us to determine the optimal time resolution of TPM in distinct experimental contexts which can be as short as 20~ms.Comment: Improved version, to appear in Physical Biology. 10 pages + 10 pages of supporting materia

Multi-objective evolutionary–fuzzy augmented flight control for an F16 aircraft

In this article, the multi-objective design of a fuzzy logic augmented flight controller for a high performance fighter jet (the Lockheed-Martin F16) is described. A fuzzy logic controller is designed and its membership functions tuned by genetic algorithms in order to design a roll, pitch, and yaw flight controller with enhanced manoeuverability which still retains safety critical operation when combined with a standard inner-loop stabilizing controller. The controller is assessed in terms of pilot effort and thus reduction of pilot fatigue. The controller is incorporated into a six degree of freedom motion base real-time flight simulator, and flight tested by a qualified pilot instructor