72 research outputs found
Estudios cientÃficos sobre el agua en el BoletÃn de la Sociedad Mexicana de GeografÃa y EstadÃstica, 1857-1869 (Estudios)
Research on the country’s water resources was published in the Bulletin of the Mexican Geography and Statistics Association (BoletÃn de la Sociedad Mexicana de GeografÃa y EstadÃstica). This article identifies the issues about water prevailing in this publication: water resources, hydraulic infrastructure projects, and their use in the city. These three issues highlight the concerns of geographers, physicians, engineers, and naturalists who recognized the value of water for the country’s economic, demographic, and social future, in addition to the difficulties of securing clean water and infrastructure projects to tackle environmental problems.En el BoletÃn de la Sociedad Mexicana de GeografÃa y EstadÃstica se publicaron investigaciones referentes a los recursos hÃdricos del paÃs. Este artÃculo identifica los temas predominantes en dicha publicación relativos al agua: recursos hÃdricos, obras hidráulicas y su uso en la ciudad. Los tres temas muestran las preocupaciones de geógrafos, médicos, ingenieros y naturalistas que reconocieron el valor del agua para el futuro económico, demográfico y social del paÃs, además de la problemática para conseguir agua potable y obras de infraestructura para resolver problemas ambientales
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage–fusion–bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage-fusion-bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors
Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
Correction to: Nature Genetics, published online 05 February 2020. In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these members should have been included in the main paper. The original Article has been corrected to include the members and affiliations of the PCAWG Consortium in the main paper; the corrections have been made to the HTML version of the Article but not the PDF version. Additional corrections to affiliations have been made to the PDF and HTML versions of the original Article for consistency of information between the PCAWG list and the main paper
Author Correction: The landscape of viral associations in human cancers
Correction to: Nature Genetics https://doi.org/10.1038/s41588-019-0558-9, published online 05 February 2020
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing (Nature Genetics, (2020), 52, 3, (331-341), 10.1038/s41588-019-0576-7)
Correction to: Nature Genetics, published online 05 February 2020. In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these members should have been included in the main paper. The original Article has been corrected to include the members and affiliations of the PCAWG Consortium in the main paper; the corrections have been made to the HTML version of the Article but not the PDF version. Additional corrections to affiliations have been made to the PDF and HTML versions of the original Article for consistency of information between the PCAWG list and the main paper
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Correction to: Nature Genetics https://doi.org/10.1038/s41588-019-0564-y, published online 05 February 2020
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Correction to: Nature Genetics https://doi.org/10.1038/s41588-019-0562-0, published online 05 February 2020
Territorio, Recursos Naturales y Ambiente: hacia una historia comparada : Estudio a través de Argentina, México, Costa Rica, HaitÃ, Paraguay, Uruguay y Venezuela
Libro -- Universidad de Costa Rica. Centro de Investigaciones GeofÃsicas, 2014Nuestro objetivo principal ha sido establecer parámetros para una estudio comparativo de los recursos naturales y el ambiente, en función del territorio, en América Latina, a partir del estudio de casos particulares. Más concetamente, nos propusimos determinar: 1. las formas de conocimiento sobre el territorio, sus recursos naturales y su ambiente; y caracterizar los estilos cientÃficos prevalecientes en cada etapa y región; 2. el papel de las instituciones y programas cientÃficos en la formación de una tradición ambientalista local y las modalidades de desarrollo de estas temáticas a lo largo de la historia latinaomericana; 3. los parámetros de comprensión de las temáticas territoriales y ambientales desde las normativas y las polÃticas públicas de los estados; 4. los objetivos, áreas de investigación,campos de interés y resultados, según surgen de las publicaciones, productos y documentación cientÃficos.Universidad de Costa Rica. Instituto Panamericano de GeografÃa e Historia (IPGH) Proyecto GEO 01.2013 – HIST. 02.2013.UCR::VicerrectorÃa de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones GeofÃsicas (CIGEFI
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