150 research outputs found
Epidemiology, comorbidities, and healthcare utilization of patients with chronic urticaria in Germany
Background: Comprehensive data on the epidemiology and comorbidities of chronic urticaria (CU) in Germany are either limited, or not contemporary.
Objectives: To investigate the epidemiology of CU, overall comorbidities and healthcare resource utilized by patients with CU in Germany, using an anonymized statutory health insurance (SHI) database.
Methods: Anonymized SHI claims research database of the Institute for Applied Health Research, Berlin [InGef] (01 January 2015-30 September 2018) was used to analyse insured individuals with a confirmed diagnosis of CU (ICD-10-GM codes). Twelve-month diagnosed prevalence and incidence, comorbidities (vs. atopic dermatitis and psoriasis), and healthcare utilization by patients with CU were investigated.
Results: Of 4 693 772 individuals of all ages listed in the database, 3 538 540 were observable during 2017. Overall, 17 524 patients (Ë0.5%) were diagnosed with CU; chronic spontaneous urticaria (CSU: 71.2%), chronic inducible urticaria (CIndU: 19.7%), CSU+CIndU (9.1%). Females, vs. males, had higher diagnosed prevalence (0.62% vs. 0.37%) and diagnosed incidence (0.18% vs. 0.11%) of CU among all patients. Patients most frequently visited general practitioners (41.3% of total visits). Hypertensive diseases (43.5%), lipoprotein metabolism disorders (32.1%) and affective disorders (26.0%) were the most frequently reported comorbidities of special interest. Rates of most comorbidities of special interests were similar to atopic dermatitis and psoriasis patients, and all higher vs. overall population. More than half (54.1%) of all CU patients were not prescribed any treatment. Second-generation H1 -antihistamines were the most commonly prescribed medication for adult (17.9%) and paediatric (27.9%) patients. Patients with CIndU (paediatric, 15.5%; adult, 7.8%) were more often hospitalized versus patients with CSU (paediatric, 9.9%; adult, 4.6%).
Conclusions: In Germany, prevalence of CU along with multiple comorbidities may pose increased burden on the healthcare system. Awareness of adhering to treatment guidelines, and aiming for complete control of urticaria, needs to be driven and may improve outcomes
Epidemiology, comorbidities, and healthcare utilization of patients with chronic urticaria in Germany
Abstract Background Comprehensive data on the epidemiology and comorbidities of chronic urticaria (CU) in Germany are either limited, or not contemporary. Objectives To investigate the epidemiology of CU, overall comorbidities and healthcare resource utilized by patients with CU in Germany, using an anonymized statutory health insurance (SHI) database. Methods Anonymized SHI claims research database of the Institute for Applied Health Research, Berlin [InGef] (01 January 2015â30 September 2018) was used to analyse insured individuals with a confirmed diagnosis of CU (ICDâ10âGM codes). Twelveâmonth diagnosed prevalence and incidence, comorbidities (vs. atopic dermatitis and psoriasis), and healthcare utilization by patients with CU were investigated. Results Of 4â693â772 individuals of all ages listed in the database, 3â538â540 were observable during 2017. Overall, 17â524 patients (Ë0.5%) were diagnosed with CU; chronic spontaneous urticaria (CSU: 71.2%), chronic inducible urticaria (CIndU: 19.7%), CSU+CIndU (9.1%). Females, vs. males, had higher diagnosed prevalence (0.62% vs. 0.37%) and diagnosed incidence (0.18% vs. 0.11%) of CU among all patients. Patients most frequently visited general practitioners (41.3% of total visits). Hypertensive diseases (43.5%), lipoprotein metabolism disorders (32.1%) and affective disorders (26.0%) were the most frequently reported comorbidities of special interest. Rates of most comorbidities of special interests were similar to atopic dermatitis and psoriasis patients, and all higher vs. overall population. More than half (54.1%) of all CU patients were not prescribed any treatment. Secondâgeneration H 1 âantihistamines were the most commonly prescribed medication for adult (17.9%) and paediatric (27.9%) patients. Patients with CIndU (paediatric, 15.5%; adult, 7.8%) were more often hospitalized versus patients with CSU (paediatric, 9.9%; adult, 4.6%). Conclusions In Germany, prevalence of CU along with multiple comorbidities may pose increased burden on the healthcare system. Awareness of adhering to treatment guidelines, and aiming for complete control of urticaria, needs to be driven and may improve outcomes
Convolution-type derivatives, hitting-times of subordinators and time-changed -semigroups
In this paper we will take under consideration subordinators and their
inverse processes (hitting-times). We will present in general the governing
equations of such processes by means of convolution-type integro-differential
operators similar to the fractional derivatives. Furthermore we will discuss
the concept of time-changed -semigroup in case the time-change is
performed by means of the hitting-time of a subordinator. We will show that
such time-change give rise to bounded linear operators not preserving the
semigroup property and we will present their governing equations by using again
integro-differential operators. Such operators are non-local and therefore we
will investigate the presence of long-range dependence.Comment: Final version, Potential analysis, 201
Vibrations and fractional vibrations of rods, plates and Fresnel pseudo-processes
Different initial and boundary value problems for the equation of vibrations
of rods (also called Fresnel equation) are solved by exploiting the connection
with Brownian motion and the heat equation. The analysis of the fractional
version (of order ) of the Fresnel equation is also performed and, in
detail, some specific cases, like , 1/3, 2/3, are analyzed. By means
of the fundamental solution of the Fresnel equation, a pseudo-process ,
with real sign-varying density is constructed and some of its properties
examined. The equation of vibrations of plates is considered and the case of
circular vibrating disks is investigated by applying the methods of
planar orthogonally reflecting Brownian motion within . The composition of
F with reflecting Brownian motion yields the law of biquadratic heat
equation while the composition of with the first passage time of
produces a genuine probability law strictly connected with the Cauchy process.Comment: 33 pages,8 figure
Low-lying GT(+) strength in Co-64 studied via the Ni-64(d,He-2)Co-64 reaction
The Ni-64(d,He-2)Co-64 reaction was studied at the AGOR cyclotron of KVI, Groningen, with the Big-Bite Spectrometer and the EuroSuperNova detector using a 171-MeV deuteron beam. An energy resolution of about 110 keV was achieved. In addition to the J(pi) = 1(+) ground state, several other 1(+) states could be identified in Co-64 and the strengths of the corresponding Gamow-Teller transitions were determined. The obtained strength distribution was compared with theoretical predictions and former (n,p) experimental results and displayed a good agreement. Due to the good energy resolution, detailed spectroscopic information was obtained, which supplements the data base needed for network calculations for supernova scenarios
Primary focal dystonia: evidence for distinct neuropsychiatric and personality profiles
Fractional Cauchy problems on bounded domains: survey of recent results
In a fractional Cauchy problem, the usual first order time derivative is
replaced by a fractional derivative. This problem was first considered by
\citet{nigmatullin}, and \citet{zaslavsky} in for modeling some
physical phenomena.
The fractional derivative models time delays in a diffusion process. We will
give a survey of the recent results on the fractional Cauchy problem and its
generalizations on bounded domains D\subset \rd obtained in \citet{m-n-v-aop,
mnv-2}. We also study the solutions of fractional Cauchy problem where the
first time derivative is replaced with an infinite sum of fractional
derivatives. We point out a connection to eigenvalue problems for the
fractional time operators considered. The solutions to the eigenvalue problems
are expressed by Mittag-Leffler functions and its generalized versions. The
stochastic solution of the eigenvalue problems for the fractional derivatives
are given by inverse subordinators
Numerical approximations for the tempered fractional Laplacian: Error analysis and applications
In this paper, we propose an accurate finite difference method to discretize
the -dimensional (for ) tempered integral fractional Laplacian and
apply it to study the tempered effects on the solution of problems arising in
various applications. Compared to other existing methods, our method has higher
accuracy and simpler implementation. Our numerical method has an accuracy of
, for if (or if ) with
, suggesting the minimum consistency conditions. The accuracy can
be improved to , for if
(or if ). Numerical experiments confirm our analytical results and provide
insights in solving the tempered fractional Poisson problem. It suggests that
to achieve the second order of accuracy, our method only requires the solution
for any . Moreover, if the solution
of tempered fractional Poisson problems satisfies for and , our method has the accuracy
of . Since our method yields a (multilevel) Toeplitz stiffness
matrix, one can design fast algorithms via the fast Fourier transform for
efficient simulations. Finally, we apply it together with fast algorithms to
study the tempered effects on the solutions of various tempered fractional
PDEs, including the Allen-Cahn equation and Gray-Scott equations.Comment: 21 pages, 11 figures, 3 table
Randomly Stopped Nonlinear Fractional Birth Processes
We present and analyse the nonlinear classical pure birth process
\mathpzc{N} (t), , and the fractional pure birth process
\mathpzc{N}^\nu (t), , subordinated to various random times, namely the
first-passage time of the standard Brownian motion , , the
-stable subordinator \mathpzc{S}^\alpha(t), , and
others. For all of them we derive the state probability distribution , and, in some cases, we also present the corresponding
governing differential equation. We also highlight interesting interpretations
for both the subordinated classical birth process \hat{\mathpzc{N}} (t),
, and its fractional counterpart \hat{\mathpzc{N}}^\nu (t), in
terms of classical birth processes with random rates evaluated on a stretched
or squashed time scale. Various types of compositions of the fractional pure
birth process \mathpzc{N}^\nu(t) have been examined in the last part of the
paper. In particular, the processes \mathpzc{N}^\nu(T_t),
\mathpzc{N}^\nu(\mathpzc{S}^\alpha(t)), \mathpzc{N}^\nu(T_{2\nu}(t)), have
been analysed, where , , is a process related to fractional
diffusion equations. Also the related process
\mathpzc{N}(\mathpzc{S}^\alpha({T_{2\nu}(t)})) is investigated and compared
with \mathpzc{N}(T_{2\nu}(\mathpzc{S}^\alpha(t))) = \mathpzc{N}^\nu
(\mathpzc{S}^\alpha(t)). As a byproduct of our analysis, some formulae
relating Mittag--Leffler functions are obtained
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