Kritiese suksesfaktore in die bemarking van nuwe industriële chemiese produkte

M.Com. (Business Management)Please refer to full text to view abstrac

Effects of iron fortification in a school feeding scheme and anthelmintic therapy on the iron status and growth of six- to eight-year-old schoolchildren

The effect of iron fortification of soup in a school feeding scheme (20 mg iron and 100 mg vitamin C per portion) and anthelmintic therapy on haematological and iron status and on growth was studied in 179 schoolchildren age six to eight years. Measurements were performed before and at the end of a sixmonth intervention and repeated five months later. In children with low baseline iron stores (serum ferritin <20 μg/L), iron fortification was associated with increases in haemoglobin Cp < .05), mean corpuscular volume (p < .01), and serum ferritin (p < .0001), compared with children who received unfortified soup. Significant positive effects of the anthelmintic therapy on haemoglobin concentrations (p < .05) and height-for-age Z scores (p < .01) were found. Children with adequate baseline iron stores showed smaller but similar changes.Articl

Response to an iron fortification programme in relation to vitamin A status in 6-12-year-old school children

Plasma retinol and indices of iron status were measured in 148 school children (6-12 years) receiving a soup fortified with iron and vitamin C for a period of 15 weeks. The most significant change in serum iron (P = 0.0005) and transferrin saturation (P = 0.0002) was seen in subjects with plasma retinol ≤ 40 μg/dl, while subjects with plasma retinol < 20 μg/dl showed no response. Serum ferritin improved most in the retinol categories < 40 μg/dl, suggesting that the absorption of iron was not impaired by marginal vitamin A status, but that it was rather the mobilisation of iron from stores that was affected. Changes in vitamin A status correlated positively and significantly with changes in serum iron (r = 0.37; P = 0.0001) transferrin saturation (r = 0.27; P = 0.004) and haemoglobin (v = 0.21; P = 0.03), but negatively with serum ferritin (r = -0.28; P = 0.003). The presence of marginal vitamin A deficiency in a community may limit the effectiveness of an iron intervention programme and vitamin A status should therefore also be considered when such programmes are planned.Articl

In vitro permeation of platinum through African and Caucasian skin

The majority of the South African workforce are Africans, therefore potential racial differences should be considered in risk and exposure assessments in the workplace. Literature suggests African skin to be a superior barrier against permeation and irritants. Previous in vitro studies on metals only included skin from Caucasian donors, whereas this study compared the permeation of platinum through African and Caucasian skin. A donor solution of 0.3 mg/ml of potassium tetrachloroplatinate (K2PtCl4) dissolved in synthetic sweat was applied to the vertical Franz diffusion cells with full thickness abdominal skin. Skin from three female African and three female Caucasian donors were included (n = 21). The receptor solution was removed at various intervals during the 24 h experiment, and analysed with high resolution inductively coupled plasma-mass spectrometry (ICP-MS). Skin was digested and analysed by inductively coupled plasma-optical emission spectrometry (ICP-OES). Significantly higher permeation of platinum through intact African skin (p = 0.044), as well as a significantly higher mass of platinum retention in African skin in comparison with Caucasian skin (p = 0.002) occurred. Significant inter-donor variation was found in both racial groups (p < 0.02). Results indicate that African workers have increased risk of dermal permeation and therefore possible sensitisation caused by dermal exposure to platinum salts. These results are contradictory to limited literature suggesting a superior barrier in African skin and further investigation is necessary to explain the higher permeation through African skinNational Research Foundation of South Africa (Thuthuka Programme) for the grant No. 80635 and the South African Medical Research Counci

The lipid and lipoprotein profile of the urban black South African population of the Cape Peninsula - the BRISK study

No Abstract

Influence of post-exercise hypoxic exposure on hepcidin response in athletes

Item does not contain fulltextPURPOSE: To assess the influence of a simulated altitude exposure (~2,900 m above sea level) for a 3 h recovery period following intense interval running on post-exercise inflammation, serum iron, ferritin, erythropoietin, and hepcidin response. METHODS: In a cross-over design, ten well-trained male endurance athletes completed two 8 x 3 min interval running sessions at 85 % of their maximal aerobic velocity on a motorized treadmill, before being randomly assigned to either a hypoxic (HYP: F IO2 ~0.1513) or a normoxic (NORM: F IO2 0.2093) 3 h recovery period. Venous blood was collected pre- and immediately post-exercise, and after 3 and 24 h of recovery. Blood was analyzed for interleukin-6, serum iron, ferritin, erythropoietin, and hepcidin. RESULTS: Interleukin-6 was significantly elevated (p < 0.01) immediately post-exercise compared to baseline (NORM: 1.08 +/- 0.061 to 3.12 +/- 1.80) (HYP: 1.32 +/- 0.86 to 2.99 +/- 2.02), but was not different between conditions. Hepcidin levels were significantly elevated (p < 0.01) at 3 h post-exercise for both conditions when compared to baseline (NORM: 3.25 +/- 1.23 to 7.40 +/- 4.00) (HYP: 3.24 +/- 1.94 to 5.42 +/- 3.20), but were significantly lower (p < 0.05) in the HYP trial compared to NORM. No significant differences existed between HYP and NORM for erythropoietin, serum iron, or ferritin. CONCLUSION: Simulated altitude exposure (~2,900 m) for 3 h following intense interval running attenuates the peak hepcidin levels recorded at 3 h post-exercise. Consequently, a hypoxic recovery after exercise may be useful for athletes with compromised iron status to potentially increase acute dietary iron absorption