8 research outputs found
Phytochemical profiles of lemon verbena ( Lippia citriodora
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Chemistry, Biogenesis, and Biological Activities of Cinnamomum zeylanicum
- Author
- Al-Logmani A. S.
- Angmor J. E.
- Archtander S.
- Badei A. Z.M.
- Begum J. M.
- Chalchat J. C.
- Cheng B. Q.
- Dongmo P. M.J.
- G. K. Jayaprakasha
- Galli A.
- Genin S. A.
- Glinski J.
- Harborne J. B.
- Ji X. D.
- Jirovetz L.
- Jirovetz L.
- Kim N. M.
- Krishna S.
- L. Jagan Mohan Rao
- Lawrence B. M.
- Levine L.
- Lew J.
- Lis Balchin M.
- Luckner M.
- Montes-Belmont R.
- Nath S. C.
- Paillot-Caressole M.
- Patel K.
- Prakash Rao E. V.S.
- Quirin K. W.
- Rogers J. A.
- Schantz M. V.
- Senanayake U. M.
- Sinha S. C.
- Soderling J.
- Straus D. A.
- Sung E. L.
- Tateo F.
- Torssell K. B.G.
- Vernin C.
- Vernin G.
- Wang H. F.
- Yong Y. R.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Adsorption and thermodynamic behaviour of U(VI) on the Tendurek volcanic tuff
- Author
- A Krestou
- A Sari
- A Silber
- C Aharoni
- C Colella
- C Raji
- CA Francois
- CA Sikalidis
- CH Weijden Van Der
- CK Jain
- CR Preetha
- D Humelnicu
- D. Alkim Turkozu
- E Erdem
- E Maranon
- F Helferrich
- F Ruggieri
- G Mckay
- G Parsons
- H Mimura
- Hasan A. Aycan
- HJ Turin
- I Anghel
- JR Bargar
- L Turanli
- M Eral
- MAA Aslani
- Mahmoud A. A. Aslani
- MF El-Shahet
- MH Dai
- MM Badei Abdel
- NK Amin
- R Cintoli
- R Harjula
- R Qadeer
- R Qadeer
- S (Doyurum) Yusan
- S Ahmed
- S Aksoyoglu
- S Akyil
- S Aytas
- S Cerjan Stefanovic
- S Doyurum
- S Shawky
- Sabriye Yusan
- Sema Akyil
- SK Milonjic
- SM Hasany
- Sule Aytas
- Y Tachi
- Y Yilmaz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Iron Complexes Derived from {nacnac-(CH 2
- Author
- Addison A. W.
- Adhikari D.
- Allen F. H.
- Andersen R. A.
- Andres H.
- Annibale V. T.
- Atienza C. C. H. A.
- Badei Y. M.
- Bailey B. C.
- Baird M. C.
- Bart S. C.
- Bart S. C.
- Bartholomew E. R.
- Basuli F.
- Benard M.
- Blackmore K. J.
- Blackmore K. J.
- Blanchard S.
- Bouwkamp M. W.
- Bowman A. C.
- Bowman A. C.
- Budzelaar P. H. M.
- Buschmann W. E.
- Carlin R. L.
- Caulton K. G.
- Chang K. C.
- Chapouret Y.
- Chiang K. P.
- Chlopek K.
- Chlopek K.
- Collins R. L.
- Corneliu S.
- Cowley R. E.
- Cowley R. E.
- Cowley R. E.
- Dai F.
- Dai X. L.
- Dai X. L.
- Darmon J. M.
- De Bruin B.
- Dias G. H. M.
- Dugan T. R.
- Dugan T. R.
- Dzik W. I.
- Eckert N. A.
- El-Zoghbi I.
- Emil B. Lobkovsky
- Evangelio E.
- Evans D. F.
- Fan H. J.
- Figgis B. N.
- Frazier B. A.
- Frazier B. A.
- Frazier B. A.
- Frazier B. A.
- Frazier B. A.
- Frisch M. J.
- Fultz B.
- Gephart R. T.
- Gephart R. T.
- Ghosh P.
- Gianetti T. L.
- Gianetti T. L.
- Gianetti T. L.
- Goldstein M.
- Gupta A. K.
- Gütlich P.
- Hadzovic A.
- Haneline M. R.
- Heinrich M. P.
- Heyduk A. F.
- Holland P. L.
- Holland P. L.
- Hope J. M.
- Hoyt J. M.
- Hulley E. B.
- Jiao R.
- Jörg Sutter
- Jørgensen C. K.
- Karpiniec S. S.
- Karsten Meyer
- Ketterer N. A.
- Khusniyarov M. M.
- Kilgore U. J.
- Kim W. K.
- Kogut E.
- Kogut E.
- Krishnan R.
- Lee Y.
- Lee Y.
- Lin K. M.
- Lippert C. A.
- Lu C. C.
- Lu C. C.
- MacAdams L. A.
- MacAdams L. A.
- MacAdams L. A.
- MacNeil J. H.
- Mankad N. P.
- Marlier E. E.
- Marlier E. E.
- Marshak M. P.
- Marshall-Roth T.
- Mindiola D. J.
- Mindiola D. J.
- Monfette S.
- Monillas W. H.
- Monillas W. H.
- Monillas W. H.
- Monillas W. H.
- Neese F.
- Neese F.
- Nguyen A. I.
- Olmstead M. M.
- Orio M.
- Parish R. V.
- Peter T. Wolczanski
- Phillips A. D.
- Phillips A. D.
- Pierpont C. G.
- Ray K.
- Rodriguez M. M.
- Rolle C. J.
- Russell S. K.
- Russell S. K.
- Schubert E. M.
- Sinnecker S.
- Smith A. L.
- Smith J. M.
- Smith J. M.
- Stieber S. C. E.
- Sylvester K. T.
- Thammavongsy Z.
- Therien M. J.
- Thomas R. Cundari
- Tomson N. C.
- Tomson N. C.
- Tomson N. C.
- Tondreau A. M.
- Tondreau A. M.
- Tondreau A. M.
- Tondreau A. M.
- Tonzetich Z. J.
- Tran B. L.
- Tran B. L.
- Tran B. L.
- Trovitch R. J.
- Tsai Y. C.
- Valerie A. Williams
- Vasudev P.
- Vela J.
- Volpe E. C.
- Volpe E. C.
- Whitehorne T. J. J.
- Wiese S.
- Wile B. M.
- Williams V. A.
- Yao S. L.
- Yu R. P.
- Yu Y.
- Zarkesh R. A.
- Zhao G. Y.
- Zhao Y.
- Zhou W.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania
- Author
- A Barral
- A Dostálová
- A Edlund
- A Poinsignon
- A Poinsignon
- A Poinsignon
- A Warburg
- AA Link
- AC Chagas
- AM Carvalho
- AP Souza
- B Londono-Renteria
- BB Andrade
- BJ Mans
- BJ Mans
- BR Soares
- C Teixeira
- C Teixeira
- Camila I. de Oliveira
- CM Snapper
- CM Theodos
- CO Anjili
- CO Vasconcelos
- CR Teixeira
- D Bahia
- D Savoia
- DB Prates
- DB Prates
- DE Champagne
- DJ Costa
- DM Aquino
- DN Xanthos
- E Calvo
- E Dama
- E Rossi
- EA Lerner
- EN Loría-Cervera
- F Oliveira
- F Oliveira
- F Oliveira
- F Silva
- G Arango Duque
- G Hasko
- G Hasko
- G van Zandbergen
- GC Lanzaro
- GC Paesen
- Genevieve Milon
- H Isawa
- H Kato
- H Kato
- HS Bezerra
- I Martín-Martín
- I Martín-Martín
- I Martín-Martín
- I Martín-Martín
- I Rohousova
- I Rohousova
- I Rohoušová
- I Rohoušová
- I Rohoušová
- IM Francischetti
- IV Coutinho-Abreu
- Iva Rohousova
- J Alvar
- J Drahota
- J Hostomska
- J Hostomska
- J Klein
- J Samuelson
- J Waitumbi
- JF Andersen
- JG Valenzuela
- JG Valenzuela
- JG Valenzuela
- JG Valenzuela
- JM Anderson
- JM Ribeiro
- JM Ribeiro
- JMC Ribeiro
- JMC Ribeiro
- K Gidwani
- K Mondragon-Shem
- KA Rogers
- LR Hall
- M Abdeladhim
- M Abdeladhim
- M Abdeladhim
- M Abdeladhim
- M Maroli
- M Ramalho-Ortigão
- M Sima
- M Sima
- M Thiakaki
- M Vlkova
- M Vlkova
- M Vlkova
- MA McDowell
- MBP Soares
- MC Monteiro
- MC Oliveira
- ME Rogers
- MF Clements
- MF Horta
- MG Collis
- Michal Sima
- ML Mbow
- N Collin
- N Collin
- NB Norsworthy
- NC Peters
- NM Abdel-Badei
- NM Tavares
- O Katz
- O Le Moine
- P Cerna
- P Volf
- P Volf
- Petr Volf
- PF Pimenta
- PH Alvarenga
- PH Alvarenga
- PJ Hotez
- PM Drame
- PT Bozza
- R Charlab
- R Gomes
- R Gomes
- R Gomes
- R Gomes
- R Killick-Kendrick
- R Molina
- R Zer
- RB Gomes
- RB Gomes
- RG Titus
- RV Morris
- S Antinori
- S Dionisotti
- S Kamhawi
- S Marzouki
- S Marzouki
- S Marzouki
- SA Miles
- T Araújo-Santos
- T Kostalova
- T Kostalova
- T Lestinova
- T Van Assche
- Tereza Lestinova
- TM Brodie
- TR de Moura
- TR de Moura
- TR de Moura
- U Ritter
- V Vinhas
- V Volfova
- X Xu
- X Xu
- Y Belkaid
- Y Belkaid
- ZY Dong
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Clinical manifestations of intermediate allele carriers in Huntington disease
- Author
- 't Hart Ep
- Aanonsen No
- Aaserud O
- Acera Gil Ma
- Akhtar S
- Allain P
- Almagro Ca
- Almeida M
- Alonso Frech F
- Andrew A
- Andrews T
- Anjum U
- Anna Bryl Ja
- Antczak J
- Antequera Torres Mm
- Arbelo Jm
- Arkuszewski M
- Armstrong R
- Arques Pn
- Arran N
- Azulay Jp
- Baake V
- Baake V
- Babiloni B
- Bachmeier M
- Bachoud Lévi Ac
- Bachoud Lévi Ac
- Badei F
- Banaszkiewicz K
- Bandmann O
- Barbera Ma
- Barnett L
- Barral Vm
- Barth K
- Barth K
- Bartoli C
- Bas J
- Bascuñana M
- Bechtel N
- Beckmann H
- Bek J
- Bentivoglio Ar
- Berglund P
- Bertini E
- Bertrand M
- Bethwaite P
- Betz S
- Biunno I
- Bjørgo K
- Boczarska Jedynak M
- Boelmans K
- Bohlen S
- Bojakowska Jaremek K
- Bojarsky Jk
- Bonelli Rm
- Borgerød N
- Bos R
- Bos R
- Bosca M
- Boudali L
- Bourdet C
- Boćwińska D
- Bradbury A
- Brockie P
- Brown S
- Brugada Carmen Peiró Vilaplana Fc
- Bruno S
- Buck A
- Burguera Ja
- Burgunder Jm
- Burgunder Jm
- Busquets N
- Busse M
- Butcher C
- Bárcenas Ah
- Błaszczyk M
- Calado A
- Caldentey Jg
- Caldentey Jg
- Caldentey Jg
- Callaghan J
- Callaghan J
- Callaghan J
- Calopa M
- Calvas F
- Calzado N
- Campolongo A
- Cannella M
- Capodarca S
- Carruesco Gt
- Cass G
- Catena Jl
- Chabot C
- Charpentier S
- Cheriet S
- Chu E
- Ciach Wysocka E
- Ciesielska A
- Classen Sj
- Clayton C
- Clenaghan C
- Cléret L
- Coarelli G
- Codella V
- Coebergh J
- Coelho M
- Come A
- Connemann J
- Constantinescu R
- Cormio C
- Corrales Kb
- Cortegana Ep
- Cosgrove J
- Couette M
- Coulthard E
- Craufurd D
- Crooks J
- Cubillo Pt
- Cubillo Pt
- Cubo E
- Curtis A
- D'Alessio B
- Davidson L
- Davison J
- De Gregorio F
- De Michele G
- De Nicola A
- de Souza J
- de Tommaso M
- Debruxelles S
- Dec M
- Dedichá Nr
- Delfini M
- Dellomonaco Ar
- Descals Am
- Di Maio L
- Di Renzo M
- Diago Eb
- Dias M
- Diercks G
- Difruscolo O
- Dipple H
- Dixon K
- Doherty K
- Donovan Jo
- Dose M
- Downie L
- Dramstad E
- Dressler D
- Duché C
- Dumas Em
- Dunnett S
- Dunnett Sb
- Dziadkiewicz A
- Ecker D
- Ecker D
- Eddy C
- Edwards R
- Eklund P
- Elifani F
- Ellrichmann G
- Esposito C
- Eusebio A
- Fairtlough H
- Fannemel M
- Feliz Cf
- Fenollar Mdel M
- Fernandez de Bobadilla R
- Fernandez Jdel V
- Fernandez Cm
- Ferraldeschi M
- Ferreira Jj
- Ferreira Jj
- Ferrer Pq
- FIGORILLI MICHELA
- Fillingham K
- Finisterra Am
- Finisterra Am
- Fluchere F
- Focseneanu C
- Fortunato F
- Foster J
- Foustanos I
- Frades B
- Francis F
- Franco G
- Frech Fa
- Fredlund G
- Frich J
- Frontali M
- Frost J
- Fullam R
- Fullam R
- Fullam R
- Fuller K
- Fullerton N
- Gallantree D
- Ganos C
- García de Yébenes J
- García Moreno Jm
- García Ramos García R
- García A
- Garde Mb
- Garreau C
- Gaston I
- Gayde Stephan S
- Geitner C
- Genoves C
- Gethin L
- Ghelli E
- Ghenam A
- Gill P
- Gilling M
- Ginestroni A
- Goerendt I
- Gogol A
- Gohier B
- Goizet C
- Golding C
- Gomez Esteban Jc
- González A
- González S
- Gorospe A
- Gorzkowska A
- Gorzolla H
- Gowers L
- Grabska N
- Grosjean H
- Guedes Lc
- Guedes Lc
- Guia Db
- Guisasola Lm
- Gundersen H
- Guérid Ma
- Göpfert N
- Gørvell P
- Haggag K
- Haider S
- Hallam C
- Hamer S
- Handley Oj
- Handley Oj
- Hare M
- Harrison D
- Hayward B
- Heiberg A
- Heiberg A
- Heinicke W
- Held C
- Held C
- Hensman D
- Hermoso Fd
- Hernanz Lc
- Herrera Cd
- Herrmann L
- Hidding U
- Hiivola H
- Hjermind L
- Hobson E
- Hoffmann R
- Hofstetter N
- Holmes K
- Horta Barba A
- Howard L
- Hughes M
- Hunt S
- Huson S
- Hvalstedt C
- Hypponen H
- Hölzner E
- Høsterey Ugander U
- Illmann T
- Jachinska K
- Jack R
- Jacobs M
- Jacobsen O
- Jacopini G
- Jameau L
- Jamieson S
- Jamrozik Z
- Janik P
- Januário C
- Jasińska Myga B
- Johannessen Ch
- Johns N
- Johnson L
- Jones L
- Jones M
- Jones U
- José García Ruíz P
- José Sainz Artiga M
- Júlio F
- Kaczmarczyk A
- Kaelin A
- Kaminska A
- Kaminski B
- Kampstra A
- Kazoka M
- Kesse A
- Khalil H
- Klebe S
- Klimberg A
- Koivisto Sp
- Koivisto Sp
- Komati S
- Konkel A
- Koppers K
- Kosinski Cm
- Kramer B
- Kraus A
- Krawczyk M
- Krishnamoorthy A
- Krysa W
- Kubowicz E
- Kwiecinski H
- Kłodowska Duda G
- Lafoucrière D
- Lahiri N
- Lahiri N
- Lamanna C
- Landwehrmeyer B
- Landwehrmeyer Gb
- Lange H
- Large S
- Larsen Iu
- Laurà M
- Lemoine L
- Levey J
- Lewerenz J
- Lewerenz J
- Lewis M
- Leypold C
- Lezius F
- Lindquist S
- Longthorpe M
- Lopera Mr
- Lovo F
- Lozano Ps
- Lucena Cm
- López Del Val J
- López Sendón Moreno Jl
- López E
- López Rg
- Malec Litwinowicz M
- Malo de Molina R
- Manzanares S
- Marcinkowski J
- Marie Bost Db
- Mariscal N
- Marit de Weert A
- Markova I
- Marquard R
- Marquine L
- MARROSU FRANCESCO
- Martikainen K
- Martin Vp
- Martinez Horta S
- Martinez Horta S
- Martinez Jaurrieta Md
- Martinez Lm
- Martino T
- Martín I
- Martínez Descals A
- Martínez Nr
- Massarelli M
- Mata Mp
- Matheson K
- Mazzante I
- Mcdonnell S
- Mcentagart M
- Mckenzie S
- Mechi C
- Mendes T
- Merino Bt
- Mestre T
- Mestre T
- Middleton J
- Miedzybrodzka Z
- Milkereit E
- Minet C
- Minschke R
- Minster S
- Minster S
- Mohammed Z
- Monza D
- Moreau Lv
- Moreno Pg
- Morgado G
- Morgado J
- Morgan K
- Mundler L
- Muroni A
- Murphy H
- Musacchio T
- Musgrave H
- Muñoz Jm
- Mühlbäck A
- Münchau A
- Mütze L
- Narożańska E
- Neleborn Lingefjärd L
- Nemeth Ah
- Nepper S
- Nevitt L
- Nielsen J
- Nielsen Je
- Niess A
- Noad R
- Novak M
- Nowak M
- Nowak M
- Nöth K
- O'Donovan K
- O'Donovan K
- Oehmen M
- Olivier A
- Opala G
- Orth M
- Orth M
- Oughton E
- Owen M
- Padieu H
- Paganini M
- Pagonabarraga J
- Palmer A
- Pardo Sa
- Pariente J
- Parkinson A
- Partington Jones L
- Pastor Bv
- Patel A
- Paterski L
- Patino Df
- Patton M
- Peacy C
- Peluso S
- Peppa N
- Peppa N
- Perea Fn
- Perez Jp
- Periañez Jm
- Peterson M
- Petrollini M
- Peña Jc
- Phillips M.
- Piacentini S
- Piedad J
- Pierre M
- PIRAS VALERIA
- Powell K
- Pradella S
- Price K
- Prieto Mp
- Probst D
- Prouzet J
- Prundean A
- Pueyo Am
- Päivärinta M
- Quarrell O
- Rae D
- Rakowicz M
- Raman A
- Ramirez Il
- Ramos Arroyo M
- Ramos Arroyo Ma
- Raseta R
- Read J
- Redondo L
- Reetz K
- Regeur L
- Reilmann R
- Retterstøl L
- Ribacoba R
- Riballo Av
- Ribas Gg
- Ribaï P
- Richter P
- Rickards H
- Rinaldi C
- Rindal B
- Ristori G
- Robert Mf
- Robertson N
- Robowski P
- Roca A
- Roca E
- Rogers D
- Rogers D
- Rohm S
- Rola R
- Rolland S
- Romano S
- Romero Lemos Md
- Romero I
- Romero Sg
- Romoli Am
- Roos Ra
- Roos Ra
- Rosa Mm
- Rosby O
- Rose S
- Rosser A
- Rosser E
- Rothery J
- Rowett L
- Rudzińska M
- Rudzińska M
- Ruiz Idiago Jm
- Rummel J
- Rumpf S
- Russo Cv
- Ryglewicz D
- Røren N
- Saft C
- Salgueiro A
- Salvador C
- Salvatore E
- Samara H
- Sass C
- Sass C
- Savage L
- Schepers S
- Scherer Gagou C
- Schiefer J
- Schlangen C
- Schmalfeld J
- Schneider A
- Schoonderbeek A
- Schrader C
- Schwenk D
- Schüpbach M
- Sciruicchio V
- Sebaiti M
- Sebastián Ar
- Sebastián Ar
- Seliverstov Y
- Semedo C
- Sempołowicz J
- Seris A
- Serpino C
- Sienkiewicz Jarosz H
- Sieradzan K
- Sikiric A
- Simonelli M
- Simpson Sa
- Singh B
- Sitek E
- Siuda G
- Slawek J
- Snowden J
- Solberg O
- Sollom A
- Soltan W
- Soltysiak B
- Sorbi S
- Sorrentino P
- Spampinato U
- Squitieri F
- Stebler Y
- Stenwak A
- Stockholm J
- Stompel D
- Stopford C
- Stubbe L
- Stępniak I
- Summers F
- Sułek A
- Szczudlik A
- Szczygieł E
- Szinwelski M
- Sánchez V
- Süssmuth S
- Tabrizi S
- Tabrizi Sj
- Tacik P
- Tartari Díaz Zorita Jp
- Taylor C
- Taylor C
- Taylor R
- Thiriez C
- Thomas G
- Thompson J
- Tidswell K
- Timewell E
- Timings L
- Toscano J
- Townhill J
- Townhill J
- Trautmann S
- Trender Gerhard I
- Tucci T
- Tuuha K
- Udaeta B
- Uhrova T
- Ure A
- VACCA MELISA IRIS SABINA
- Valadas A
- Valentine R
- van den Bogaard Sj
- van Hout Ms
- Van Paemel D
- van Vugt Jp
- van Walsem M
- van Walsem Mr
- Vandenberghe W
- Vangsted Hansen C
- Vaquie V
- Vaughn V
- Ventura Mf
- Verellen Dumoulin C
- Verellen Dumoulin C
- Verhoeven M
- Verny C
- Verstraelen N
- Vervoitte L
- Vezza M
- Vieira da Silva W
- Viladrich Cm
- Villa C
- Villanueva C
- Villanueva Má
- Vinther Jensen T
- Wahlström J
- Wahlström J
- Warner T
- Wasielewska A
- Weber N
- Wehus R
- Werner Cj
- Westmoreland L
- Weydt P
- Wild E
- Wild S
- Williams J
- Witjes Ané Mn
- Witkowski G
- Witkowski G
- Wiśniewski B
- Wood J
- Wright A
- Wright A
- Wright J
- Wójcik M
- Yardumian P
- Yates S
- Youssov K
- Yudina E
- Zaremba J
- Zaremba J
- Zaugg Sw
- Zdzienicka E
- Zea Sevilla Ma
- Zielonka D
- Zielonka D
- Zielonka E
- Zinzi P
- Zinzi P
- Ziora Jakutowicz K
- Zittel S
- Šašinková P
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
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- Aaserud O
- Abbruzzese G
- Acera Gil Ma
- Ackermann O
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- Wahlström J
- Wahlström J
- Wallden T
- Walleczek Am
- Wannepain S
- Warner T
- Wasielewska A
- Weber N
- Weckx P
- Weekes R
- Weekes R
- Wehus R
- Weindl A
- Wenning G
- Wermuth L
- Werner Cj
- Westman L
- Westmoreland L
- Weydt P
- Whaite A
- Wider C
- Widner H
- Wiklund L
- Wikström B
- Wild E
- Wild S
- Williams J
- Winkelmann J
- Winkler J
- Winnberg E
- Witjes-Ané Mn
- Witjes-Ané Mn
- Witkowski G
- Witkowski G
- Wiśniewski B
- Wolz A
- Wolz M
- Wood J
- Wood S
- Wright A
- Wright A
- Wright J
- Wójcik M
- Yardumian P
- Yates S
- Youssov K
- Yudina E
- Yudina E
- Zalyalova Z
- Zaremba J
- Zaremba J
- Zaugg Sw
- Zdzienicka E
- Zea Sevilla Ma
- Ziegler C
- Zielonka D
- Zielonka D
- Zielonka E
- Zimmermann Ma
- Zinzi P
- Zinzi P
- Zinzi P
- Ziora-Jakutowicz K
- Zittel S
- Zouitina Y
- Zucker B
- Åman J
- Østern R
- Šašinková P
- Šenkárová Z
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30\u201350 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of 6435 or a UHDRS motor score of 645 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, 120.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients
Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study
- Author
- \u160a\u161inkov\ue1 Pavla
- \u160enk\ue1rov\ue1 Zuzana
- \uc5man Jaana
- Aaserud Olaf
- Abbruzzese Giovanni
- Agarwal Veena
- Akhtar Shahbana
- Alarc\uf3n Moreau Mar\ueda Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen Ant\ufanez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrich J\ufcrgen
- Angeles Maria
- Aniola Jacek
- Anjum Uruj
- Annic Agn\ue8s
- Antczak Jakub
- Arbelo Jos\ue9 Mat\uedas
- Arkuszewski Michal
- Armstrong Richard
- Arntsen Vibeke
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- Artiga Mar\ueda Jos\ue9 Sainz
- Azulay Jean-Philippe
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- De Gregorio Francesca
- De La Cerda Santa Mar\ueda Andr\ue9s
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- De Molina Roc\uedo Malo
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- De Tommaso Marina
- De Weert A. Marit
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- Dujardin Kathy
- Dumas Eve M.
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- Dupuis Michel
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- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J
- Ferrer Pilar Quil\ue9z
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- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir M\ue9lissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Torres Mar\ueda Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Valentine Ruth
- Van De Wyngaerde Fran\ue7oise
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Reijen Dimphna
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vaughan Vivien
- Ventura Marta Fat\ue1s
- Verellen-Dumoulin Christine
- Verhoeven Marloes
- Vernon Nathan
- Verny Christophe
- Verstappen Carla
- Verstraelen Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Viladrich C\ue8lia Mareca
- Vilaplana Carmen Peir\uf3
- Villa Riballo Antonio
- Villa Carolina
- Villanueva Clara
- Villanueva Marina \uc1vila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- W\uf3jcik Magdalena
- Waber Mirella
- Wagner Caroline
- Wahlstr\uf6m Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wi\u15bniewski Bartlomiej
- Wider Christian
- Wikstr\uf6m Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler J\ufcrgen
- Witjes-An\ue9 Marie-Noelle
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'IOS Press'
- Publication date
- 01/01/2018
- Field of study
Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis