New ways of creating and sharing bibliographic information: an experiment of using the Wikibase Data Model for UNIMARC data

Starting from the consideration that UNIMARC (and in general the MARC) is in fact an ontology, this contribution proposes to make it explicit and to convert it – only at a syntactic level – in Linked Data / RDF structures through the use of the Wikibase data model. The outcome could therefore become not only the publication of data as LOD, but also an environment for the production of bibliographic data, that allows different ontological approaches. We illustrate the possibility to achieve a restructuring of the UNIMARC record into distinct items by data type (potentially referred also to the different FRBR entities), retaining the possibility to recover all the information of the original format. Then we highlight the Wikibase solutions that become exploitable for the MARC: “usable version” of the record, with explicitation of the encoded values, and definitions connected to the data in the same system; identification of univocal data with URIs, as required in the context of the semantic web; source of the data recorded for each field; statistics on the presence of fields and subfields; new storage format natively designed for collaborative editing; export of all elements in standard RDF; support of modification via open API.Starting from the consideration that UNIMARC (and in general the MARC) is in fact an ontology, this contribution proposes to make it explicit and to convert it – only at a syntactic level – in Linked Data / RDF structures through the use of the Wikibase data model. The outcome could therefore become not only the publication of data as LOD, but also an environment for the production of bibliographic data, that allows different ontological approaches. We illustrate the possibility to achieve a restructuring of the UNIMARC record into distinct items by data type (potentially referred also to the different FRBR entities), retaining the possibility to recover all the information of the original format. Then we highlight the Wikibase solutions that become exploitable for the MARC: “usable version” of the record, with explicitation of the encoded values, and definitions connected to the data in the same system; identification of univocal data with URIs, as required in the context of the semantic web; source of the data recorded for each field; statistics on the presence of fields and subfields; new storage format natively designed for collaborative editing; export of all elements in standard RDF; support of modification via open API

Nuovi modi di produrre e condividere l'informazione bibliografica: una sperimentazione dell’uso del Wikibase Data Model per i dati UNIMARC

Starting from the consideration that UNIMARC (and in general the MARC) is in fact an ontology, this contribution proposes to make it explicit and to convert it – only at a syntactic level – in Linked Data / RDF structures through the use of the Wikibase data model. The outcome could therefore become not only the publication of data as LOD, but also an environment for the production of bibliographic data, that allows different ontological approaches. We illustrate the possibility to achieve a restructuring of the UNIMARC record into distinct items by data type (potentially referred also to the different FRBR entities), retaining the possibility to recover all the information of the original format. Then we highlight the Wikibase solutions that become exploitable for the MARC: “usable version” of the record, with explicitation of the encoded values, and definitions connected to the data in the same system; identification of univocal data with URIs, as required in the context of the semantic web; source of the data recorded for each field; statistics on the presence of fields and subfields; new storage format natively designed for collaborative editing; export of all elements in standard RDF; support of modification via open API

Nuovi modi di produrre e condividere l'informazione bibliografica: una sperimentazione dell’uso del Wikibase Data Model per i dati UNIMARC

Starting from the consideration that UNIMARC (and in general the MARC) is in fact an ontology, this contribution proposes to make it explicit and to convert it – only at a syntactic level – in Linked Data / RDF structures through the use of the Wikibase data model. The outcome could therefore become not only the publication of data as LOD, but also an environment for the production of bibliographic data, that allows different ontological approaches. We illustrate the possibility to achieve a restructuring of the UNIMARC record into distinct items by data type (potentially referred also to the different FRBR entities), retaining the possibility to recover all the information of the original format. Then we highlight the Wikibase solutions that become exploitable for the MARC: “usable version” of the record, with explicitation of the encoded values, and definitions connected to the data in the same system; identification of univocal data with URIs, as required in the context of the semantic web; source of the data recorded for each field; statistics on the presence of fields and subfields; new storage format natively designed for collaborative editing; export of all elements in standard RDF; support of modification via open API

life cycle assessment lca of landfill gas management comparison between conventional technologies and microbial oxidation systems

Abstract The reduction of landfill gas emissions is a central issue of the Directive 99/31/EC. Biofilters and biocovers have been identified as an alternative and cost-effective technologies to mitigate impacts due to CH4 and NMVOCs emissions. The Life Cycle Assessment demonstrates the environmental sustainability of biofiltration systems, with the aim of improving the environmental impact indicators such as Global Warming (-10.75% for Biofilter and -11.60% for Biocover) and Photochemical oxidation (-7.97% for Biofilter and -8.61%. for Biocover). This paper shows that these treatment technologies are effective for methane oxidation when the calorific value of the LFG is low, thus they maximize the amount of treated gas during the after-care phase

A new splicing isoform of Cacna2d4 mimicking the effects of c.2451insC mutation in the retina: Novel molecular and electrophysiological insights

PURPOSE. Mutations in CACNA2D4 exon 25 cause photoreceptor dysfunction in humans (c.2406CA mutation) and mice (c.2451insC mutation). We investigated the feasibility of an exon-skipping therapeutic approach by evaluating the splicing patterns and functional role of targeted exons. METHODS. Splicing of the targeted a2d4 (CACNA2D4) exons in presence and absence of the mutation was assessed by RT-PCR in vivo on mouse retinae and in vitro in HEK293T cells using splicing-reporter minigenes. Whole-cell patch-clamp recordings were performed to evaluate the impact of different Cacna2d4 variants on the biophysical properties of Cav1.4 Ltype calcium channels (CACNA1F). RESULTS. Splicing analysis revealed the presence of a previously unknown splicing isoform of a2d4 in the retina that truncates the gene open reading frame (ORF) in a similar way as the c.2451insC mutation. This isoform originates from alternative splicing of exon 25 (E25) with a new exon (E25b). Moreover, the c.2451insC mutation has an effect on splicing and increases the proportion of transcripts including E25b. Our electrophysiological analyses showed that only full-length a2d4 was able to increase Cav1.4/b3-mediated currents while all other a2d4 variants did not mediate such effect. CONCLUSIONS. The designed exon-skipping strategy is not applicable because the resulting skipped a2d4 are nonfunctional. a2d4 E25b splicing variant is normally present in mouse retina and mimics the effect of c.2451insC mutation. Since this variant does not promote significant Cav1.4-mediated calcium current, it could possibly mediate a different function, unrelated to modulation of calcium channel properties at the photoreceptor terminals

Synthesis of Imidazolidin-2-ones and Imidazol-2-ones via Base-Catalyzed Intramolecular Hydroamidation of Propargylic Ureas under Ambient Conditions

The first organo-catalyzed synthesis of imidazolidin-2-ones and imidazol-2-ones via intramolecular hydroamidation of propargylic ureas is reported. The phosphazene base BEMP turned out to be the most active organo-catalyst compared with guanidine and amidine bases. Excellent chemo- and regioselectivities to five-membered cyclic ureas have been achieved under ambient conditions, with a wide substrate scope and exceptionally short reaction times (down to 1 min). A base-mediated isomerization step to an allenamide intermediate is the most feasible reaction pathway to give imidazol-2-ones, as suggested by DFT studies

Fatty Acids Composition of Stomach Oil of Scopoli’s Shearwater (Calonectris diomedea) from Linosa’s Colony

Calonectris diomedea is a Procellariforms seabird having a very representative colony in Linosa Island (Southern Italy). The adult forms of C. diomedea produce a pasty oil from their proven- triculus to feed their chicks during the rearing period. In this work, we examined the fatty acids composition of the stomach oil of C. diomedea from Linosa Island by gas chromatography with flame ionization detection (GC-FID). The samples were collected at 20 and 70 days after hatching. Twenty different fatty acids (FAs) were identified. Saturated fatty acids (SFA) were the most abundant in percentage (41.6%) at day 20 followed by polyunsaturated fatty acids (PUFA, 38.7%) and monounsat- urated fatty acids (MUFA, 19.7%). MUFAs were the most abundant in samples collected at day 70 (53.8%), followed by SFAs (36.6%) and PUFAs (9.8%). Oleic acid (C18:1ω9) in the samples on day 70 was 4 times higher than that in the samples on day 20. The Principal Component Analysis (PCA) verified a clear separation of the stomach oil samples in two groups, according to the day of sampling. The results obtained confirm the role of FAs analysis of stomach oil to understand the ecology and breeding behaviour of C. diomedea, highlighting a resemblance with signatures recorded in marine organisms of Linosa Island

Differences in cardiac phenotype and natural history of laminopathies with and without neuromuscular onset

Objective: To investigate differences in cardiac manifestations of patients affected by laminopathy, according to the presence or absence of neuromuscular involvement at presentation.Methods: We prospectively analyzed 40 consecutive patients with a diagnosis of laminopathy followed at a single centre between 1998 and 2017. Additionally, reports of clinical evaluations and tests prior to referral at our centre were retrospectively evaluated.Results: Clinical onset was cardiac in 26 cases and neuromuscular in 14. Patients with neuromuscular presentation experienced first symptoms earlier in life (11 vs 39 years; p < 0.0001) and developed atrial fibrillation/flutter (AF) and required pacemaker implantation at a younger age (28 vs 41 years [p = 0.013] and 30 vs 44 years [p = 0.086] respectively), despite a similar overall prevalence of AF (57% vs 65%; p = 0.735) and atrio-ventricular (A-V) block (50% vs 65%; p = 0.500). Those with a neuromuscular presentation developed a cardiomyopathy less frequently (43% vs 73%; p = 0.089) and had a lower rate of sustained ventricular tachyarrhythmias (7% vs 23%; p = 0.387). In patients with neuromuscular onset rhythm disturbances occurred usually before evidence of cardiomyopathy. Despite these differences, the need for heart transplantation and median age at intervention were similar in the two groups (29% vs 23% [p = 0.717] and 43 vs 46 years [p = 0.593] respectively).Conclusions: In patients with laminopathy, the type of disease onset was a marker for a different natural history. Specifically, patients with neuromuscular presentation had an earlier cardiac involvement, characterized by a linear and progressive evolution from rhythm disorders (AF and/or A-V block) to cardiomyopathy