The mathematical simulation of the temperature fields of building envelopes under permanent frozen soil conditions

The physical-mathematical model of the thermal state of the aired technical underground taking into account the air exchange and design features of construction under permanent frozen soil conditions has been suggested. The computational scheme of the temperature fields prediction of building envelopes of projected buildings and soil under and nearby buildings has been developed. The numerical simulation of the temperature fields of building envelopes changes was conducted during a year. The results of the numerical simulation showed that the heat coming from the technical undergrounds and through the walls does not influence the temperature field of the soil neither under a building nor at a distance from it

Missing children: risks, repeats and responses

Investigating reports of missing children is a major source of demand for the police in the UK. Repeat disappearances are common, can indicate underlying vulnerabilities and have been linked with various forms of exploitation and abuse. Inspired by research on repeat victimisation, this paper examines the prevalence and temporal patterns of repeat missing episodes by children, as well as the characteristics of those involved. Using data on all missing children incidents recorded by one UK police service in 2015 (n = 3,352), we find that: (a) 75% of missing incidents involving children were repeats, i.e. attributed to children who had already been reported missing in 2015; (b) a small proportion of repeatedly missing children (n = 59; 4%) accounted for almost a third of all missing children incidents (n = 952, 28%); (c) over half of all first repeat disappearances occurred within four weeks of an initial police recorded missing episode; and (d) children recorded as missing ten times or more over the one year study period were significantly more likely than those recorded missing once to be teenagers, in the care system or to have drug and/or alcohol dependencies. We conclude by discussing the implications of our findings for future research and the prevention of repeat disappearances by children

Missing Children: On the Extent, Patterns, and Correlates of Repeat Disappearances by Young People

Missing persons investigations are arguably the most common and costly non-crime problem the police are expected to handle, with a large proportion of all cases attributable to young people. This article investigates the prevalence, time course, distance, and correlates of repeat disappearances by children (under the age of 18 years). Using data from one UK police force for the period January 2011 to May 2013 (n = 1,885), we find that (1) nearly two-thirds of all missing child reports are repeat disappearances, (2) a small proportion of children who go missing repeatedly (15%) account for over half of all missing persons incidents, (3) children who go missing repeatedly tend to travel shorter distances than children reported missing once, and (4) the likelihood of a child going missing on multiple occasions is associated with age, being in care, a history of family conflict, and if going missing was judged to be ‘out of character’. The implications of our findings for the prevention of repeat disappearances by young people are discussed

Calcium modulates the domain flexibility and function of an α\alpha-actinin similar to the ancestral α-actinin

The actin cytoskeleton, a dynamic network of actin filaments and associated F-actin–binding proteins, is fundamentally important in eukaryotes. α-Actinins are major F-actin bundlers that are inhibited by Ca$^{2+}$ in nonmuscle cells. Here we report the mechanism of Ca$^{2+}$-mediated regulation of Entamoeba histolytica α-actinin-2 (EhActn2) with features expected for the common ancestor of Entamoeba and higher eukaryotic α-actinins. Crystal structures of Ca$^{2+}$-free and Ca$^{2+}$-bound EhActn2 reveal a calmodulin-like domain (CaMD) uniquely inserted within the rod domain. Integrative studies reveal an exceptionally high affinity of the EhActn2 CaMD for Ca$^{2+}$, binding of which can only be regulated in the presence of physiological concentrations of Mg$^{2+}$. C$^{2+}$ binding triggers an increase in protein multidomain rigidity, reducing conformational flexibility of F-actin–binding domains via interdomain cross-talk and consequently inhibiting F-actin bundling. In vivo studies uncover that EhActn2 plays an important role in phagocytic cup formation and might constitute a new drug target for amoebic dysentery