Polycations XXII. Ru(bpy)2L2 and Ru(phen)2L2 Systems with Cationic 4,4’-Bipyridine Ligands: Syntheses, Characteristics, and Interactions with DNA

Earlier efforts have been concerned with the association of Ruthenium octahedral complexes with DNA. Since the positively charged ruthenium species has been found to associate with the electron rich major groove of double-stranded DNA, it was proposed the addition of cationic sites on the ligands attached to ruthenium would facilitate such association. Thus, we have synthesized several series of octahedral ruthenium complexes bearing ligands having within themselves cationic sites. These have been investigated in their interaction with calf thymus DNA using fluorescence titration analysis. The introduction of the cationic ligands has been found to exhibit enhanced association of the ruthenium (II) species with the DNA as compared to those without such ligands, in keeping with the original concept. This work leads us to conclude that this line of investigation can lead to useful pharmaceutical agents

Correlating the rheological and magneto-optical properties of cobalt substituted magnetite ferrofluids (CoxFe1?xFe2O4) with theoretical studies

Magnetite ferrofluids are widely reported due to their outstanding physicochemical, magnetic and antibacterial properties. This study focusses on the synthesis of magnetite ferrofluids and the effect of Co2+ substitution on their structural, optical, magnetic and rheological properties. An environmental friendly method of co-precipitation is applied to generate CoxFe1?xFe2O4 with variable dopant concentration (x = 0-0.8), which is deeply investigated by structural and functional property analyses of the ferrofluids. X-ray diffraction shows cubic spinel structure without the formation of secondary phase and morphology analysis reveals the formation of spherical nanoparticles of 6-11 nm size. Additionally, the optical, magnetic and rheological properties of the ferrofluids are investigated in depth. The optical measurement results demonstrate shift in band edge positions to blue region with decrease in particle size because of the quantum confinement effect. Magnetic measurements using SQUID studies illustrate the decrease in saturation magnetization from 56.4 emu/g to 41.08 emu/g, with increase in the concentration of the cobalt dopant. Faraday rotation of CoxFe1?xFe2O4 ferrofluids is measured depending on the different concentrations of cobalt in applied magnetic field. Finally the influence of magnetic field on the viscosity of Co2+ substituted magnetite ferrofluids are investigated, and a deep investigation is done by correlating the experimental details with theoretical modelling like Langevin fitting. Ultimately, the cobalt substitution in ferrofluids reports a smart tuning strategy to change the magneto-optical and magneto-rheological properties of the materials, for making them suitable in medicinal therapy. 2023 The AuthorsScopu

Polycations XX: New Monodentate Cationic Ligands and Their Coordination with Ruthenium for the Construction of Complexes Expressing Enhanced Interaction with DNA

Prior investigations from this laboratory concerned with the preparation of new types of organic cations for a variety of biological and nonbiological applications have been extended to the preparation of cation-bearing ligands with nitrogen coordinating sites for use in complexation reactions with ruthenium cores. The syntheses of new cationic ligands as well as ruthenium complexes bearing them are reported here. The introduction of these new types of ligands is intended to provide to the complexes an enhanced ability to interact with DNA, and thereby to have the potential to be enhanced antitumor agents. Preliminary observations of their interactions with DNA are presented

Structural influence of chromium substituted magnetite ferrofluids on the optical and antibacterial characteristics

A series of chromium substituted magnetite (CrxFe1?xFe2O4) ferrofluids with various concentrations ranging from x = 0-0.8 is reported in this work. Simple, cost effective and gentle co-precipitation method is followed for the synthesis, involving the stabilization by tetramethylammoniumhydroxide (TMOAH). Ultrafine nanoparticles of magnetite ferrofluids with good homogeneity exhibit promising structural, optical and magnetic, characteristics. The optimization and control of magnetic grain size during the co-precipitation reaction by regulating the experimental conditions (temperature and pH) ensures the formation of least possible grains. In addition, the grain growth is restricted by the surfactant (TMOAH) by in situ capping. The well optimized crystalline structure of the magnetic nanoparticles influence the morphological features, optical band gap, saturation magnetization, magnetic coercivity and remanence. As the composition of Cr increases from x = 0.2 to x = 0.8, the crystalline size decreases reaching a minimum value of 9 nm. At the same time, the magnetic moment also becomes 1.3 +- 0.08 at a saturation point of 33 +- 0.13 emu/g at the highest Cr composition. For all compositions, the optical band gaps vary within 1.35-2.3 eV range. The antibacterial activity of chromium-substituted ferrofluids against Escherischia coli and Staphylococcus aureus is highlighted in this study. The high content of chromium ions (x = 0-0.8) in the magnetite ferrofluids coupled with the smaller particle sizes generate strong anti-microbial activity for the particles and thereby find application in medical field. 2023 The AuthorsFinancial assistance provided from Indian Council of Medical Research (ICMR) in the form of Research Associate (Grant No. 5/3/8/95/ITR F/2020 ).Scopu

“Evaluation of Protective Effect of Aegle Marmelos Fruits Extract against Streptozotocin Induced Type 1 Diabetes Mellitus in Rat’s Model”

Aegle mamelos, known as Bael, is a plant that has been used for the therapy of several healths of disorders. All plant parts include stem, bark, root, leaves, fruit and seeds have medicinal virtues and have been used in Ethno-medicine.   Objective: The present study aims to investigate the activity of methanolic extract of Aegle marmelos on Type I anti-diabetic in STZ induced in rat’s model. Methods: Extracted Aegle marmelos fruits were evaluated for the anti-diabetic activity. Type I Diabetes has been induced in Wistar rats through STZ 65mg/kg/b.w.I.P. During the experiment, rat’s body weight and fasting blood sugar levels were monitored. At the end of study, animals all groups have been sacrificed and biochemical parameters such as; lipid profile, C-Peptide, HbA1c, serum insulin, pancreatic insulin, histology of pancreas have been observed. Furthermore, levels antioxidant enzymes SOD, CAT, and LPO were measured. Result: The observed extract Aegle marmelos was proven to be safe in the toxicity findings. It has been shown in-vivo significant effect to manage the diabetic markers such as weight gain, blood glucose, lipid profile, C-Peptide, HbA1c, release of insulin secretion and pancreatic insulin. Diabetic pancreas of rats have been observed fall over beta cell density and disruption of normal architecture, but treated groups have been determined to restore the mass over beta cells. Elevated oxidative enzymes also have been viewed to control on the treatment with Aegle marmelos. Conclusion: All its findings and phytoconstituents existing inside the extract must stay the viable chemical materials involved into the prevention of diabetes Keywords: Aegle marmelos, Streptozotocin, Anti-Diabetic activity, Glucose, Insuli