PROBLEMS RELATED TO PEDAGOGICAL SUPPORT SYSTEM OF CHILDREN WITH HEARING IMPAIRMENT OR DISORDERS IN REPUBLIC OF ARMENIA

In this article distinctive features related to the characteristic of children with hearing disorders due to story perception, teachers’ awareness level of research results related to mentioned problems, and some cultivated and justified approaches are presented. All researches are implemented in Republic of Armenian Tigranyan No 14 special school.In this article distinctive features related to the characteristic of children with hearing disorders due to story perception, teachers’ awareness level of research results related to mentioned problems, and some cultivated and justified approaches are presented. All researches are implemented in Republic of Armenian Tigranyan No 14 special school

Experimental Investigation of the Nature of the Knee in the Primary Cosmic Ray Energy Spectrum with the GAMMA experiment

We present preliminary results obtained by a novel difference method for the study of the nature of the knee in the energy spectrum of the primary cosmic radiation. We have applied this method to data from the GAMMA experiment in Armenia. The analysis provides evidence for the possible existence of a nearby source of primary cosmic rays in the Southern hemisphere.Comment: 17 pages, 5 figure

The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts

Our aim in this study was to observe the movements of filarial infective larvae following inoculation into the mammalian host and to assess the effect of vaccination on larval migration, in situ. Here we present recordings of larvae progressing through the subcutaneous tissues and inguinal lymph node of primary infected or vaccinated mice. We used the filaria Litomosoides sigmodontis in BALB/c mice that were necropsied 6 hours after the challenge inoculation of 200 larvae. Subcutaneous tissue sections were taken from the inoculation site and larvae were filmed in order to quantify their movements. Our analyses showed that the subcutaneous larvae were less motile in the vaccinated mice than in primary-infected mice and had more leucocytes attached to the cuticle. We propose that this reduced motility may result in the failure of a majority of larvae to evade the inflammatory reaction, thereby being a possible mechanism involved in the early vaccine-induced protection

Spatially resolved simulation of a radio frequency driven micro atmospheric pressure plasma jet and its effluent

Radio frequency driven plasma jets are frequently employed as efficient plasma sources for surface modification and other processes at atmospheric pressure. The radio-frequency driven micro atmospheric pressure plasma jet ($\mu$APPJ) is a particular variant of that concept whose geometry allows direct optical access. In this work, the characteristics of the $\mu$APPJ operated with a helium-oxygen mixture and its interaction with a helium environment are studied by numerical simulation. The density and temperature of the electrons, as well as the concentration of all reactive species are studied both in the jet itself and in its effluent. It is found that the effluent is essentially free of charge carriers but contains a substantial amount of activated oxygen (O, O$_3$ and O$_2(^1\Delta)$). The simulation results are verified by comparison with experimental data

Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes

<p>Background: Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a vaccine against filariasis may depend on its capacity to counter parasite-driven immunomodulation.</p> <p>Methodology and Principal Findings: We immunised mice with DNA plasmids expressing functionally-inactivated forms of two immunomodulatory molecules expressed by the filarial parasite Litomosoides sigmodontis: the abundant larval transcript-1 (LsALT) and cysteine protease inhibitor-2 (LsCPI). The mutant proteins enhanced antibody and cytokine responses to live parasite challenge, and led to more leukocyte recruitment to the site of infection than their native forms. The immune response was further enhanced when the antigens were targeted to dendritic cells using a single chain Fv-αDEC205 antibody and co-administered with plasmids that enhance T helper 2 immunity (IL-4) and antigen-presenting cell recruitment (Flt3L, MIP-1α). Mice immunised simultaneously against the mutated forms of LsALT and LsCPI eliminated adult parasites faster and consistently reduced peripheral microfilaraemia. A multifactorial analysis of the immune response revealed that protection was strongly correlated with the production of parasite-specific IgG1 and with the numbers of leukocytes present at the site of infection.</p> <p>Conclusions: We have developed a successful strategy for DNA vaccination against a nematode infection that specifically targets parasite-driven immunosuppression while simultaneously enhancing Th2 immune responses and parasite antigen presentation by dendritic cells.</p&gt

Experimental Investigation of Flow and Coherent Properties of Excited Non-Circular Liquid Jets

Non-circular jet is identified as an efficient passive flow-control technique that attracts many research topics. The existence of twine-vortexes is the main reason for dissimilarity between circular and non-circular jets. Which also influences the production of droplets and satellites as well as the jet instability. This investigation presents instability analysis of liquid-gas interface as an applicable conception in free-jet flows. We experiment different jet geometries within a gas ambient in order to study their hydrodynamic behavior. These studies give an appropriate perception about contributing forces that play essential roles in fluid instability. We focus on varying viscosity and surface tension as our excitation techniques. These methods are vital to examine the key properties of non-circular jets such as breakup and decay length, axis-switching wavelength as well as produced droplets and satellites characteristics. First, instabilities of charged liquid jets are investigated by considering the interaction between electric and inertial forces. Also, the viscosity effect was studied for its interaction with the inertial and surface tension forces. In each case, liquid jet in-stability for various nozzle geometries over a specific range of jet velocity is examined. The obtained results illustrate that the geometry of nozzle has an important effect on jet instability. In addition, by increment of We number, the breakup and decay length as well as the axis-switching wavelength are raising. However, by the rise of twin-vortex number, the breakup length increases but the decay length and axis-switching wavelength decrease

Ionization by bulk heating of electrons in capacitive radio frequency atmospheric pressure microplasmas

Electron heating and ionization dynamics in capacitively coupled radio frequency (RF) atmospheric pressure microplasmas operated in helium are investigated by Particle in Cell simulations and semi-analytical modeling. A strong heating of electrons and ionization in the plasma bulk due to high bulk electric fields are observed at distinct times within the RF period. Based on the model the electric field is identified to be a drift field caused by a low electrical conductivity due to the high electron-neutral collision frequency at atmospheric pressure. Thus, the ionization is mainly caused by ohmic heating in this "Omega-mode". The phase of strongest bulk electric field and ionization is affected by the driving voltage amplitude. At high amplitudes, the plasma density is high, so that the sheath impedance is comparable to the bulk resistance. Thus, voltage and current are about 45{\deg} out of phase and maximum ionization is observed during sheath expansion with local maxima at the sheath edges. At low driving voltages, the plasma density is low and the discharge becomes more resistive resulting in a smaller phase shift of about 4{\deg}. Thus, maximum ionization occurs later within the RF period with a maximum in the discharge center. Significant analogies to electronegative low pressure macroscopic discharges operated in the Drift-Ambipolar mode are found, where similar mechanisms induced by a high electronegativity instead of a high collision frequency have been identified

The birth of a healthy child in a married couple with a history of multiple unsuccessful attempts at ART by selecting sperm on oocyte-cumulus complexes. Case report

In male infertility, couples must use assisted reproductive technologies with the intracytoplasmic sperm injection (ICSI) technique. A significant disadvantage of ICSI is bypassing natural selection barriers since selective processes in the female reproductive tract are replaced by the choice of an embryologist based on sperm motility and morphological criteria. Various selection methods are being actively studied, bringing fertilization by ICSI closer to physiological, ensuring the selection of sperm with high DNA quality and good potential for fertilization. The article presents a clinical case of the birth of a healthy child in a married couple with severe male infertility and many ineffective attempts at assisted reproductive technologies using the method of sperm selection on oocyte-cumulus complexes. The child is physically healthy and develops according to age

Armenia and Belarus: caught between the EU's and Russia's conditionalities?

This article looks into Armenia's and Belarus’ engagement with the European Union's (EU) and Russia's conditionalities, the two EU Eastern Partnership (EaP) countries that are also members of the Russia-led Eurasian Economic Union (EAEU). While paying attention to political, economic (including energy and technical) as well as security dimensions of the EU's and Russia's approaches, as proposed in the present special section, the article demonstrates that the conditionalities extended by the EU and Russia to the two countries in question have differed. In their turn, Armenia and Belarus have reacted differently to Russia's and the EU's conditionalities. Against the backdrop of the changing significance ascribed to both the EU's and Russia's policies towards their common neighbourhood since the 1990s, the present contribution identifies and analyses factors that account for the diverging positions of Armenia and Belarus, including the type of regime, the geopolitical considerations, the stakes in the economic and energy spheres and the predisposition to integration. The article shows that in the resulting complex context, Armenia and Belarus have been able to influence the shape and content of the EU's and Russia's conditionalities, although in a different way and to a different extent.Ministry of Education and Science (UID/CPO/ 00758/2013