624 research outputs found
Knotted holomorphic discs in
We construct knotted proper holomorphic embeddings of the unit disc i
Inhibition of high risk HPV-31 in human cervical epithelial cells in vitro by the PC-PLC inhibitor LMV-601
Optimizing the computation of overriding
We introduce optimization techniques for reasoning in DLN---a recently
introduced family of nonmonotonic description logics whose characterizing
features appear well-suited to model the applicative examples naturally arising
in biomedical domains and semantic web access control policies. Such
optimizations are validated experimentally on large KBs with more than 30K
axioms. Speedups exceed 1 order of magnitude. For the first time, response
times compatible with real-time reasoning are obtained with nonmonotonic KBs of
this size
Surface properties changing of biodegradable polymers by the radio frequency magnetron sputtering modification
Towards Correctness of Program Transformations Through Unification and Critical Pair Computation
Correctness of program transformations in extended lambda calculi with a
contextual semantics is usually based on reasoning about the operational
semantics which is a rewrite semantics. A successful approach to proving
correctness is the combination of a context lemma with the computation of
overlaps between program transformations and the reduction rules, and then of
so-called complete sets of diagrams. The method is similar to the computation
of critical pairs for the completion of term rewriting systems. We explore
cases where the computation of these overlaps can be done in a first order way
by variants of critical pair computation that use unification algorithms. As a
case study we apply the method to a lambda calculus with recursive
let-expressions and describe an effective unification algorithm to determine
all overlaps of a set of transformations with all reduction rules. The
unification algorithm employs many-sorted terms, the equational theory of
left-commutativity modelling multi-sets, context variables of different kinds
and a mechanism for compactly representing binding chains in recursive
let-expressions.Comment: In Proceedings UNIF 2010, arXiv:1012.455
Insulin Glargine in the Intensive Care Unit: A Model-Based Clinical Trial Design
Online 4 Oct 2012Introduction: Current succesful AGC (Accurate Glycemic Control) protocols require extra clinical effort and are impractical in less acute wards where patients are still susceptible to stress-induced hyperglycemia. Long-acting insulin Glargine has the potential to be used in a low effort controller. However, potential variability in efficacy and length of action, prevent direct in-hospital use in an AGC framework for less acute wards.
Method: Clinically validated virtual trials based on data from stable ICU patients from the SPRINT cohort who would be transferred to such an approach are used to develop a 24-hour AGC protocol robust to different Glargine potencies (1.0x, 1.5x and 2.0x regular insulin) and initial dose sizes (dose = total insulin over prior 12, 18 and 24 hours). Glycemic control in this period is provided only by varying nutritional inputs. Performance is assessed as %BG in the 4.0-8.0mmol/L band and safety by %BG<4.0mmol/L.
Results: The final protocol consisted of Glargine bolus size equal to insulin over the previous 18 hours. Compared to SPRINT there was a 6.9% - 9.5% absolute decrease in mild hypoglycemia (%BG<4.0mmol/L) and up to a 6.2% increase in %BG between 4.0 and 8.0mmol/L. When the efficacy is known (1.5x assumed) there were reductions of: 27% BG measurements, 59% insulin boluses, 67% nutrition changes, and 6.3% absolute in mild hypoglycemia.
Conclusion: A robust 24-48 clinical trial has been designed to safely investigate the efficacy and kinetics of Glargine as a first step towards developing a Glargine-based protocol for less acute wards. Ensuring robustness to variability in Glargine efficacy significantly affects the performance and safety that can be obtained
Pyrroloquinoline quinone and molecules mimicking its functional domains Modulators of connective tissue formation?
Get my pizza right: Repairing missing is-a relations in ALC ontologies (extended version)
With the increased use of ontologies in semantically-enabled applications,
the issue of debugging defects in ontologies has become increasingly important.
These defects can lead to wrong or incomplete results for the applications.
Debugging consists of the phases of detection and repairing. In this paper we
focus on the repairing phase of a particular kind of defects, i.e. the missing
relations in the is-a hierarchy. Previous work has dealt with the case of
taxonomies. In this work we extend the scope to deal with ALC ontologies that
can be represented using acyclic terminologies. We present algorithms and
discuss a system
Algorithm for Adapting Cases Represented in a Tractable Description Logic
Case-based reasoning (CBR) based on description logics (DLs) has gained a lot
of attention lately. Adaptation is a basic task in the CBR inference that can
be modeled as the knowledge base revision problem and solved in propositional
logic. However, in DLs, it is still a challenge problem since existing revision
operators only work well for strictly restricted DLs of the \emph{DL-Lite}
family, and it is difficult to design a revision algorithm which is
syntax-independent and fine-grained. In this paper, we present a new method for
adaptation based on the DL . Following the idea of
adaptation as revision, we firstly extend the logical basis for describing
cases from propositional logic to the DL , and present a
formalism for adaptation based on . Then we present an
adaptation algorithm for this formalism and demonstrate that our algorithm is
syntax-independent and fine-grained. Our work provides a logical basis for
adaptation in CBR systems where cases and domain knowledge are described by the
tractable DL .Comment: 21 pages. ICCBR 201
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