Status of the Search for Charge Symmetry Breaking in n-p Scattering

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

A Measurement of C_NN in n-p Scattering at 188 MeV

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

Progress on the Charge-Symmetry-Breaking Experiment

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

Status of the Experimental Search for Charge Symmetry Breaking in n-p Scattering

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma

The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing and implicated in more than 60% of all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, and proteome analyses have identified altered signaling pathways in HPV-induced HNSCCs, additional tools are needed to investigate the unique pathobiology of OPSCC. Herein, bioinformatics analyses of human HPV(+) HNSCCs revealed that all tumors express full-length E6 and identified molecular subtypes based on relative E6 and E7 expression levels. To recapitulate the levels, stoichiometric ratios, and anatomic location of E6/E7 expression, we generated a genetically engineered mouse model whereby balanced expression of E6/E7 is directed to the oropharyngeal epithelium. The addition of a mutant PIK3CAE545K allele leads to the rapid development of pre-malignant lesions marked by immune cell accumulation, and a subset of these lesions progress to OPSCC. This mouse provides a faithful immunocompetent model for testing treatments and investigating mechanisms of immunosuppression

Experimental Facilities Development

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

Predicting haemodynamic networks using electrophysiology: The role of non-linear and cross-frequency interactions

Understanding the electrophysiological basis of resting state networks (RSNs) in the human brain is a critical step towards elucidating how inter-areal connectivity supports healthy brain function. In recent years, the relationship between RSNs (typically measured using haemodynamic signals) and electrophysiology has been explored using functional Magnetic Resonance Imaging (fMRI) and magnetoencephalography (MEG). Significant progress has been made, with similar spatial structure observable in both modalities. However, there is a pressing need to understand this relationship beyond simple visual similarity of RSN patterns. Here, we introduce a mathematical model to predict fMRI-based RSNs using MEG. Our unique model, based upon a multivariate Taylor series, incorporates both phase and amplitude based MEG connectivity metrics, as well as linear and non-linear interactions within and between neural oscillations measured in multiple frequency bands. We show that including non-linear interactions, multiple frequency bands and cross-frequency terms significantly improves fMRI network prediction. This shows that fMRI connectivity is not only the result of direct electrophysiological connections, but is also driven by the overlap of connectivity profiles between separate regions. Our results indicate that a complete understanding of the electrophysiological basis of RSNs goes beyond simple frequency-specific analysis, and further exploration of non-linear and cross-frequency interactions will shed new light on distributed network connectivity, and its perturbation in pathology

Recommended adult immunization schedule, United States, 2020

In October 2019, the Advisory Committee on Immunization Practices (ACIP) voted to approve the Recommended Adult Immunization Schedule for Ages 19 Years or Older, United States, 2020. The 2020 adult immunization schedule, available at www.cdc.gov/vaccines /schedules/hcp/imz/adult.html, summarizes ACIP recommendations in 2 tables and accompanying notes (Figure). The full ACIP recommendations for each vaccine are available at www.cdc.gov/vaccines/hcp/acip-recs/index.html. The 2020 schedule has also been approved by the director of the Centers for Disease Control and Prevention (CDC) and by the American College of Physicians (www .acponline.org), American Academy of Family Physicians (www.aafp.org), American College of Obstetricians and Gynecologists (www.acog.org), and American College of Nurse-Midwives (www.midwife.org)

Search for Charge Symmetry Breaking (CSB) in pol.n-pol.p Scattering

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

CHARGE SYMMETRY BREAKING IN n-p SCATTERING AT 183 MeV

La dépendance en fonction du spin des asymétries gauche-droite a été mesurée sur une grande région angulaire (60° c.m.) dans la diffusion élastique de neutrons polarisés sur des protons polarisés. La symétrie de charge exige que les pouvoirs d'analyses proton et neutron doivent être égaux. Nos résultats préliminaires pour leur différence ΔA(Θ) = An(Θ) - Ap(Θ), moyennée sur la région angulaire 82.2° <Θcm < 116.1° est de (32.1 ± 6.1 ± 6)x10-4, avec respectivement les erreurs statistique et systématique. De plus, l'expérience est sensible, et nous l'extrayons à la partie de la distribution angulaire ΔA qui est orthogonal à A(Θ) lui-même. Nos résultats sont bien décrits par des calculs d'échange de meson qui prennent en compte la différence de mass n-p, ainsi qu'une contribution comparable du mélange ρ-ω. Le dépouillement final confirme la valeur moyenne initiale de ΔA et résoud plusieurs incertitudes de l'erreur systématique.Spin-dependent left-right asymmetries have been measured over a broad angular range (60° c.m.) for polarized neutrons elastically scattered from polarized protons. Charge symmetry requires the neutron and proton analyzing powers to be equal. Our preliminary result for their difference ΔA (Θ) = An(Θ) - Ap (Θ), averaged over the angular range 82.2° <Θcm < 116.1° is (32.1 ± 6.1 ± 6) x 10-4, with statistical and systematic uncertainties, respectively. Our experiment is also sensitive to, and we extract, that part of the angular dependence of ΔA, which is orthogonal to A(Θ) itself. Overall, our data are well-described by meson-exchange calculations which include the effect of the n-p mass difference on one boson exchange, and comparably large contributions from ρ-ω mixing. Final replay results substantiate our initial averaged ΔA value and settle several systematic error uncertainties