802 research outputs found
On the dynamic response of an instrumented headform for alternative mounting stiffnesses when subjected to ballistic impacts
© 2017, © IMechE 2017. The current British Standard for head protectors for cricketers has been recently revised to include a projectile-based battery of tests, the intention being to ensure that a certified helmet will also prevent contact of the ball or grille with the specified headform facial region. The purpose of this study was to characterise the dynamic response of the headform to direct ballistic impacts for alternative headform mounting arrangements. On one hand, and in accordance with the relevant sections of the Standard, what might be described as a ‘Constrained’ setup was evaluated while, on the other hand, an arrangement with significantly reduced stiffness, in line with that previously reported for the passive human neck, was subject to equivalent appraisal. For each mounting scenario, an air cannon was used to project a cricket training ball at three speeds towards the instrumented headform at three locations with five repeats per speed/location combination. High-rate/resolution video and piezoelectric accelerometer data were collected and processed to determine the headform response. While differences between specific ball impact speed and location scenarios are set out in detail later in the article, overall observations are summarised as follows. From a ball/headform contact duration standpoint, video derived results showed ranges of 1.30–1.45 ms (Constrained) versus 1.26–1.41 ms. Maximum ball deformations, the timing of which enabling the event to be subdivided into ‘loading’ and ‘unloading’ phases, were found to be 82.5%–86.2% (Constrained) versus 82.8%–86.4% of original ball diameter; mean peak headform accelerations during loading were found to be 860–1615 m/s2 (Constrained) versus 967–1638 m/s2; and headform speeds at the end of the loading phase were found to be 0.5–0.92 m/s (Constrained) versus 0.54–0.93 m/s. Differences between headform response for the two mounting arrangements were observed to be more substantial during the loading rather than unloading phase
Temporal transcriptome changes induced by MDV in marek's disease-resistant and -susceptible inbred chickens
<p>Abstract</p> <p>Background</p> <p>Marek's disease (MD) is a lymphoproliferative disease in chickens caused by Marek's disease virus (MDV) and characterized by T cell lymphoma and infiltration of lymphoid cells into various organs such as liver, spleen, peripheral nerves and muscle. Resistance to MD and disease risk have long been thought to be influenced both by genetic and environmental factors, the combination of which contributes to the observed outcome in an individual. We hypothesize that after MDV infection, genes related to MD-resistance or -susceptibility may exhibit different trends in transcriptional activity in chicken lines having a varying degree of resistance to MD.</p> <p>Results</p> <p>In order to study the mechanisms of resistance and susceptibility to MD, we performed genome-wide temporal expression analysis in spleen tissues from MD-resistant line 6<sub>3</sub>, susceptible line 7<sub>2 </sub>and recombinant congenic strain M (RCS-M) that has a phenotype intermediate between lines 6<sub>3 </sub>and 7<sub>2 </sub>after MDV infection. Three time points of the MDV life cycle in chicken were selected for study: 5 days post infection (dpi), 10dpi and 21dpi, representing the early cytolytic, latent and late cytolytic stages, respectively. We observed similar gene expression profiles at the three time points in line 6<sub>3 </sub>and RCS-M chickens that are both different from line 7<sub>2</sub>. Pathway analysis using Ingenuity Pathway Analysis (IPA) showed that MDV can broadly influence the chickens irrespective of whether they are resistant or susceptible to MD. However, some pathways like cardiac arrhythmia and cardiovascular disease were found to be affected only in line 7<sub>2</sub>; while some networks related to cell-mediated immune response and antigen presentation were enriched only in line 6<sub>3 </sub>and RCS-M. We identified 78 and 30 candidate genes associated with MD resistance, at 10 and 21dpi respectively, by considering genes having the same trend of expression change after MDV infection in lines 6<sub>3 </sub>and RCS-M. On the other hand, by considering genes with the same trend of expression change after MDV infection in lines 7<sub>2 </sub>and RCS-M, we identified 78 and 43 genes at 10 and 21dpi, respectively, which may be associated with MD-susceptibility.</p> <p>Conclusions</p> <p>By testing temporal transcriptome changes using three representative chicken lines with different resistance to MD, we identified 108 candidate genes for MD-resistance and 121 candidate genes for MD-susceptibility over the three time points. Genes included in our resistance or susceptibility genes lists that are also involved in more than 5 biofunctions, such as <it>CD8α</it>, <it>IL8</it>, <it>USP18</it>, and <it>CTLA4</it>, are considered to be important genes involved in MD-resistance or -susceptibility. We were also able to identify several biofunctions related with immune response that we believe play an important role in MD-resistance.</p
Physical, Psychological and Emotional Benefits of Green Physical Activity: An Ecological Dynamics Perspective
© 2015 Springer International Publishing Switzerland Increasing evidence supports the multiple benefits to physical, psychological and emotional wellbeing of green physical activity, a topic of increasing interest in the past decade. Research has revealed a synergistic benefit of green physical activity, which includes all aspects of exercise and physical activity in the presence of nature. Our theoretical analysis suggests there are three distinct levels of engagement in green physical activity, with each level reported to have a positive effect on human behaviours. However, the extent to which each level of green physical activity benefits health and wellbeing is assumed to differ, requiring confirmation in future research. This elucidation of understanding is needed because previous literature has tended to focus on recording empirical evidence rather than developing a sound theoretical framework to understand green physical activity effects. Here we propose an ecological dynamics rationale to explain how and why green physical activity might influence health and wellbeing of different population groups. This framework suggests a number of unexplored, interacting constraints related to types of environment and population groups, which shape reported levels of benefit of green physical activity. Further analysis is needed to clarify the explicit relationship between green physical activity and health and wellbeing, including levels of engagement, types of environmental constraints, levels of physical activity, adventure effects, skill effects and sampling of different populations
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Attribution of 2012 extreme climate events: does air-sea interaction matter?
In 2012, extreme anomalous climate conditions occurred around the globe. Large areas of North America experienced an anomalously hot summer, with large precipitation deficits inducing severe drought. Over Europe, the summer of 2012 was marked by strong precipitation anomalies with the UK experiencing its wettest summer since 1912 while Spain suffered severe drought. What caused these extreme climate conditions in various regions in 2012? This study compares attribution conclusions for 2012 climate anomalies relative to a baseline period (1964–1981) based on two sets of parallel experiments with different model configurations (with coupling to an ocean mixed layer model or with prescribed sea surface temperatures) to assess whether attribution conclusions concerning the climate anomalies in 2012 are sensitive to the representation of air-sea interaction. Modelling results indicate that attribution conclusions for large scale surface air temperature (SAT) changes in both boreal winter and summer are generally robust and not very sensitive to air-sea interaction. This is especially true over southern Europe, Eurasia, North America, South America, and North Africa. Some other responses also appear to be insensitive to air-sea interaction: for example, forced increases in precipitation over northern Europe and Sahel, and reduced precipitation over North America and the Amazon in boreal summer. However, the attribution of circulation and precipitation changes for some other regions exhibits a sensitivity to air-sea interaction. Results from the experiments including coupling to an ocean mixed layer model show a positive NAO-like circulation response in the Atlantic sector in boreal winter and weak changes in the East Asian summer monsoon and precipitation over East Asia. With prescribed sea surface temperatures, some different responses arise over these two regions. Comparison with observed changes indicates that the coupled simulations generally agree better with observations, demonstrating that attribution methods based on atmospheric general circulation models have limitations and may lead to erroneous attribution conclusions for regional anomalies in circulation, precipitation and surface air temperature
Precision Measurement of the Mass of the h_c(1P1) State of Charmonium
A precision measurement of the mass of the h_c(1P1) state of charmonium has
been made using a sample of 24.5 million psi(2S) events produced in e+e-
annihilation at CESR. The reaction used was psi(2S) -> pi0 h_c, pi0 -> gamma
gamma, h_c -> gamma eta_c, and the reaction products were detected in the
CLEO-c detector.
Data have been analyzed both for the inclusive reaction and for the exclusive
reactions in which eta_c decays are reconstructed in fifteen hadronic decay
channels. Consistent results are obtained in the two analyses. The averaged
results of the present measurements are M(h_c)=3525.28+-0.19 (stat)+-0.12(syst)
MeV, and B(psi(2S) -> pi0 h_c)xB(h_c -> gamma eta_c)= (4.19+-0.32+-0.45)x10^-4.
Using the 3PJ centroid mass, Delta M_hf(1P)= - M(h_c) =
+0.02+-0.19+-0.13 MeV.Comment: 9 pages, available through http://www.lns.cornell.edu/public/CLNS/,
submitted to PR
Precision Measurement of B(D+ -> mu+ nu) and the Pseudoscalar Decay Constant fD+
We measure the branching ratio of the purely leptonic decay of the D+ meson
with unprecedented precision as B(D+ -> mu+ nu) = (3.82 +/- 0.32 +/-
0.09)x10^(-4), using 818/pb of data taken on the psi(3770) resonance with the
CLEO-c detector at the CESR collider. We use this determination to derive a
value for the pseudoscalar decay constant fD+, combining with measurements of
the D+ lifetime and assuming |Vcd| = |Vus|. We find fD+ = (205.8 +/- 8.5 +/-
2.5) MeV. The decay rate asymmetry [B(D+ -> mu+ nu)-B(D- -> mu- nu)]/[B(D+ ->
mu+ nu)+B(D- -> mu- nu)] = 0.08 +/- 0.08, consistent with no CP violation. We
also set 90% confidence level upper limits on B(D+ -> tau+ nu) < 1.2x10^(-3)
and B(D+ -> e+ nu) < 8.8x10^(-6).Comment: 24 pages, 11 figures and 6 tables, v2 replaced some figure vertical
axis scales, v3 corrections from PRD revie
J/psi and psi(2S) Radiative Transitions to eta_c
Using 24.5 million psi(2S) decays collected with the CLEO-c detector at CESR
we present the most precise measurements of magnetic dipole transitions in the
charmonium system. We measure B(psi(2S)->gamma eta_c) =
(4.32+/-0.16+/-0.60)x10^-3, B(J/psi->gamma eta_c)/B(psi(2S)->gamma eta_c) =
4.59+/-0.23+/-0.64, and B(J/psi->gamma eta_c) = (1.98+/-0.09+/-0.30)%. We
observe a distortion in the eta_c line shape due to the photon-energy
dependence of the magnetic dipole transition rate. We find that measurements of
the eta_c mass are sensitive to the line shape, suggesting an explanation for
the discrepancy between measurements of the eta_c mass in radiative transitions
and other production mechanisms.Comment: 11 pages, 3 figure
Inclusive chi_bJ(nP) Decays to D0 X
Using Upsilon(2S) and Upsilon(3S) data collected with the CLEO III detector
we have searched for decays of chi_bJ to final states with open charm. We fully
reconstruct D0 mesons with p_D0 > 2.5 GeV/c in three decay modes (K-pi+,
K-pi+pi0, and K-pi-pi+pi+) in coincidence with radiative transition photons
that tag the production of one of the chi_bJ(nP) states. We obtain significant
signals for the two J=1 states. Recent NRQCD calculations of chi_{bJ}(nP) --> c
cbar X depend on one non-perturbative parameter per chi_bJ triplet. The
extrapolation from the observed D0 X rate over a limited momentum range to a
full c cbar X rate also depends on these same parameters. Using our data to fit
for these parameters, we extract results which agree well with NRQCD
predictions, confirming the expectation that charm production is largest for
the J=1 states. In particular, for J=1, our results are consistent with c cbar
g accounting for about one-quarter of all hadronic decays.Comment: Version 2 updates include corrections to important errors in Table V
and VII column headers which summarize results, and additional minor edits.
17 pages, available through http://www.lns.cornell.edu/public/CLNS
Measurement of the Absolute Branching Fraction of D_s^+ --> tau^+ nu_tau Decay
Using a sample of tagged D_s decays collected near the D^*_s D_s peak
production energy in e+e- collisions with the CLEO-c detector, we study the
leptonic decay D^+_s to tau^+ nu_tau via the decay channel tau^+ to e^+ nu_e
bar{nu}_tau. We measure B(D^+_s to tau^+ nu_tau) = (6.17 +- 0.71 +- 0.34) %,
where the first error is statistical and the second systematic. Combining this
result with our measurements of D^+_s to mu^+ nu_mu and D^+_s to tau^+ nu_tau
(via tau^+ to pi^+ bar{nu}_tau), we determine f_{D_s} = (274 +- 10 +- 5) MeV.Comment: 9 pages, postscript also available through
http://www.lns.cornell.edu/public/CLNS/2007/, revise
A Step Towards Seascape Scale Conservation: Using Vessel Monitoring Systems (VMS) to Map Fishing Activity
Published onlineJournal ArticleResearch Support, Non-U.S. Gov'tBACKGROUND: Conservation of marine ecosystems will require a holistic understanding of fisheries with concurrent spatial patterns of biodiversity. METHODOLOGY/PRINCIPAL FINDINGS: Using data from the UK Government Vessel Monitoring System (VMS) deployed on UK-registered large fishing vessels we investigate patterns of fisheries activity on annual and seasonal scales. Analysis of VMS data shows that regions of the UK European continental shelf (i.e. Western Channel and Celtic Sea, Northern North Sea and the Goban Spur) receive consistently greater fisheries pressure than the rest of the UK continental shelf fishing zone. CONCLUSIONS/SIGNIFICANCE: VMS provides a unique and independent method from which to derive patterns of spatially and temporally explicit fisheries activity. Such information may feed into ecosystem management plans seeking to achieve sustainable fisheries while minimising putative risk to non-target species (e.g. cetaceans, seabirds and elasmobranchs) and habitats of conservation concern. With multilateral collaboration VMS technologies may offer an important solution to quantifying and managing ecosystem disturbance, particularly on the high-seas.MJW is supported by a Natural Environment Research Council PhD studentship (NER/S/A/2004/12980) at the University of Exeter (Cornwall Campus). BJG receives funding from the European Social Fund
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