15,326 research outputs found
Prepontine non-giant neurons drive flexible escape behavior in zebrafish
Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level. However, how sensory cues are integrated within premotor escape circuits remains poorly understood. Here, we show that in zebrafish, less precipitous threats elicit a delayed escape, characterized by flexible trajectories, which are driven by a cluster of 38 prepontine neurons that are completely separate from the fast escape pathway. Whereas neurons that initiate rapid escapes receive direct auditory input and drive motor neurons, input and output pathways for delayed escapes are indirect, facilitating integration of cross-modal sensory information. These results show that rapid decision-making in the escape system is enabled by parallel pathways for ballistic responses and flexible delayed actions and defines a neuronal substrate for hierarchical choice in the vertebrate nervous system
Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry
This work describes a freely available web-based facility which can be used to analyse raw or processed mass spectrometric data from metabolomics experiments and display the metabolites identified – and changes in their experimental abundance – in the context of the metabolic pathways in which they occur. The facility, Pathos (http://motif.gla.ac.uk/Pathos/), employs Java servlets and is underpinned by a relational database populated from the Kyoto Encyclopaedia of Genes and Genomes (KEGG). Input files can contain either raw m/z values from experiments conducted in different modes, or KEGG or MetaCyc IDs assigned by the user on the basis of the m/z values and other criteria. The textual output lists the KEGG pathways on an XHTML page according to the number of metabolites or potential metabolites that they contain. Filtering by organism is also available. For metabolic pathways of interest, the user is able to retrieve a pathway map with identified metabolites highlighted. A particular feature of Pathos is its ability to process relative quantification data for metabolites identified under different experimental conditions, and to present this in an easily comprehensible manner. Results are colour-coded according to the degree of experimental change, and bar charts of the results can be generated interactively from either the text listings or the pathway maps. The visual presentation of the output from Pathos is designed to allow the rapid identification of metabolic areas of potential interest, after which particular results may be examined in detail
Grid Cells Form a Global Representation of Connected Environments.
The firing patterns of grid cells in medial entorhinal cortex (mEC) and associated brain areas form triangular arrays that tessellate the environment [1, 2] and maintain constant spatial offsets to each other between environments [3, 4]. These cells are thought to provide an efficient metric for navigation in large-scale space [5-8]. However, an accurate and universal metric requires grid cell firing patterns to uniformly cover the space to be navigated, in contrast to recent demonstrations that environmental features such as boundaries can distort [9-11] and fragment [12] grid patterns. To establish whether grid firing is determined by local environmental cues, or provides a coherent global representation, we recorded mEC grid cells in rats foraging in an environment containing two perceptually identical compartments connected via a corridor. During initial exposures to the multicompartment environment, grid firing patterns were dominated by local environmental cues, replicating between the two compartments. However, with prolonged experience, grid cell firing patterns formed a single, continuous representation that spanned both compartments. Thus, we provide the first evidence that in a complex environment, grid cell firing can form the coherent global pattern necessary for them to act as a metric capable of supporting large-scale spatial navigation
Systematics of Moduli Stabilization, Inflationary Dynamics and Power Spectrum
We study the scalar sector of type IIB superstring theory compactified on
Calabi-Yau orientifolds as a place to find a mechanism of inflation in the
early universe. In the large volume limit, one can stabilize the moduli in
stages using perturbative method. We relate the systematics of moduli
stabilization with methods to reduce the number of possible inflatons, which in
turn lead to a simpler inflation analysis. Calculating the order-of-magnitude
of terms in the equation of motion, we show that the methods are in fact valid.
We then give the examples where these methods are used in the literature. We
also show that there are effects of non-inflaton scalar fields on the scalar
power spectrum. For one of the two methods, these effects can be observed with
the current precision in experiments, while for the other method, the effects
might never be observable.Comment: 20 pages, JHEP style; v.2 and v.3: typos fixed, discussion and
references adde
A comparison of the responses of mature and young clonal tea to drought.
To assist commercial producers with optimising the use of irrigation water, the
responses to drought of mature and young tea crops (22 and 5 years after field
planting respectively) were compared using data from two adjacent long-term
irrigation experiments in Southern Tanzania. Providing the maximum potential
soil water deficit was below about 400-500 mm for mature, and 200-250 mm for
young plants (clone 6/8), annual yields of dry tea from rainfed or partially
irrigated crops were similar to those from the corresponding well-watered crops.
At deficits greater than this, annual yields declined rapidly in young tea (up
to 22 kg (ha mm)-1) but relatively slowly in mature tea (up to 6.5 kg (ha mm)-
1). This apparent insensitivity of the mature crop to drought was due
principally to compensation that occurred during the rains for yield lost in the
dry season. Differences in dry matter distribution and shoot to root ratios
contributed to these contrasting responses. Thus, the total above ground dry
mass of well-irrigated, mature plants was about twice that for young plants.
Similarly, the total mass of structural roots (>1 mm diameter), to 3 m depth,
was four times greater in the mature crop than in the young crop and, for fine
roots (<1 mm diameter), eight times greater. The corresponding shoot to root
ratios (dry mass) were about 1:1 and 2:1 respectively. In addition, each unit
area of leaf in the canopy of a mature plant had six times more fine roots (by
weight) available to extract and supply water than did a young plant. Despite
the logistical benefits resulting from more even crop distribution during the
year when crops are fully irrigated, producers currently prefer to save water
and energy costs by allowing a substantial soil water deficit to develop prior
to the start of the rains, up to 250 mm in mature tea, knowing that yield
compensation will occur later
Magnetic Field Rotations in the Solar Wind at Kinetic Scales
The solar wind magnetic field contains rotations at a broad range of scales,
which have been extensively studied in the MHD range. Here we present an
extension of this analysis to the range between ion and electron kinetic
scales. The distribution of rotation angles was found to be approximately
log-normal, shifting to smaller angles at smaller scales almost self-similarly,
but with small, statistically significant changes of shape. The fraction of
energy in fluctuations with angles larger than was found to drop
approximately exponentially with , with e-folding angle at
ion scales and at electron scales, showing that large angles
() do not contain a significant amount of energy at kinetic
scales. Implications for kinetic turbulence theory and the dissipation of solar
wind turbulence are discussed
The high partial wave phenomenon of spin changing atomic transitions
The collisional transition between two highly excited atomic states with different spin is investigated theoretically. Taking helium-like n1S − n3P as an example, it is found that the transition is driven in the highly ion-ized Fe ion purely by exchange, and the cross section becomes increasingly dominated by partial waves of high orbital angular momentum as the scattering energy increases. Whereas for the near-neutral Li ion the transition is dominated by channel coupling in low partial waves. Analytical bench-marks and numerical methods are developed for the accurate calculation of the exchange integral at high angular momentum. It is shown how the partial wave and energy dependence of the collision strength for high n spin changing transitions in the highly ionized ion is related to the overlap of the extended atomic orbitals.</p
Advanced Fenton processing of aqueous phenol solutions:a continuous system study including sonication effects
Our previous report based on a batch reactor system for the Advanced Fenton Process (AFP) showed that pH, hydrogen peroxide and the organic substances treated are among the most important factors affecting the oxidation efficiency. As an extended study towards its commercialisation, this paper reports the effects of the main process parameters including those relating to a new AFP flow-through system. In order to systemise and correlate the results, the Taguchi experimental design method was used. Total organic carbon (TOC) removal was utilised as the measure of the oxidation efficiency and it was found that the removal of phenol from aqueous solution at pH 2.0 and 2.5 was very similar but hydrogen peroxide supply significantly affected the TOC removal with the change of flow rate from 14.4 mL/hr to 60 mL/hr. Also, the initial concentration of phenol was a highly significant factor, with higher concentrations resulting in a lower TOC removal rate. The temperature effects in the range of 14 °C to 42 °C were investigated and it was found that there was accelerated oxidation of phenol in the early stages but after 90 minutes there was no significant difference between the results. Sonication with a bath type sonicator resulted in relatively small enhancements of TOC removal but further studies with cup-horn and probe type sonicators showed that TOC removal increased with higher intensity of sonication on additional input of hydrogen peroxide
Sculpting the Extra Dimensions: Inflation from Codimension-2 Brane Back-reaction
We construct an inflationary model in 6D supergravity that is based on
explicit time-dependent solutions to the full higher-dimensional field
equations, back-reacting to the presence of a 4D inflaton rolling on a
space-filling codimension-2 source brane. Fluxes in the bulk stabilize all
moduli except the `breathing' modulus (that is generically present in
higher-dimensional supergravities). Back-reaction to the inflaton roll causes
the 4D Einstein-frame on-brane geometry to expand, a(t) ~ t^p, as well as
exciting the breathing mode and causing the two off-brane dimensions to expand,
r(t) ~ t^q. The model evades the general no-go theorems precluding 4D de Sitter
solutions, since adjustments to the brane-localized inflaton potential allow
the power p to be dialed to be arbitrarily large, with the 4D geometry becoming
de Sitter in the limit p -> infinity (in which case q = 0). Slow-roll solutions
give accelerated expansion with p large but finite, and q = 1/2. Because the
extra dimensions expand during inflation, the present-day 6D gravity scale can
be much smaller than it was when primordial fluctuations were generated -
potentially allowing TeV gravity now to be consistent with the much higher
gravity scale required at horizon-exit for observable primordial gravity waves.
Because p >> q, the 4 on-brane dimensions expand more quickly than the 2
off-brane ones, providing a framework for understanding why the observed four
dimensions are presently so much larger than the internal two. If uplifted to a
10D framework with 4 dimensions stabilized, the 6D evolution described here
could describe how two of the six extra dimensions evolve to become much larger
than the others, as a consequence of the enormous expansion of the 4 large
dimensions we can see.Comment: 27 pages + appendices, 2 figure
Implications for the U.S. of Anglo-French Defense Cooperation
The paper analyzes, from a predominantly UK perspective, the implications for
the U.S. of the November 2, 2010, Anglo-French Defence Cooperation Treaty. The
current pressures on British and French defence budgets were the primary driving
force behind this cooperative effort. London and Paris have made steps toward
improving joint efforts in a number of areas, with defence acquisition and
industrial cooperation being prominent. In the UK, there appears to be strong
political support at the highest levels, which has permeated to lower levels in
the bureaucracy, while the UK defence industry appears to be cautiously
optimistic about future business opportunities.
The impact of enhanced Anglo-French cooperation on the U.S. would appear to be
largely favourable for Washington. Rather than providing a basis for weakened UK
attention to the U.S., as some fear, the efforts by London and Paris will
potentially generate greater national military capability from scarce resources
and could serve as a vehicle for broader European efforts to enhance their
defence capabilities. While multinational European military development projects
are viewed with scepticism in the UK, the Anglo-French arrangement could
strengthen the prospects for bilateral projects in which other European states
may elect to participate
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