Joint Stock Companies in the Italian Legal System

In the Italian legal system a company (società) is the collective exercise of an enterprise. From an organisational point of view, companies may be divided between: (1) companies of persons and (2) share companies. Share companies may have either a profit motive or an object of mutual benefit. Share companies with a profit motive are, inter alia, the Joint Stock Companies. This is both: the principal type of company and the most appropriate company structure for large enterprises which involve a considerable capital and the assumption of a notable risk. The peculiar characteristic of this type of company is that the relationship between the company and its shareholders is impersonal and anonymous. The three distinguishing features of the SpA are: first, the liability of the shareholders is limited to their contributions; second, the participation of the shareholder in the company is represented by shares of equal nominal value; and finally, the company must have a minimum capital

Analysis of flow cytometric aneuploid DNA histograms: validation of an automatic procedure against ad hoc experimental data

In this paper we present an improved version of a method for the automatic analysis of flow cytometric DNA histograms from samples containing a mixture of two cell populations. The procedure is tested against two sets of ad hoc experimental data, obtained by mixing cultures of cell lines in different known proportions. The potentialities of the method are enlightened and discussed with regard to its capability of recovering the population percentages, the DNA index and the G0/G1, S, G2+M phase fractions of each population. On the basis of the obtained results, the procedure appears to be a promising tool in the flow cytometric data analysis and, in particular, in problems of diagnosis and prognosis of tumor diseases

Characterization, modeling and microstructure of composite aluminium alloy specimens after ECAP

none2noThe ECAP, the Equal Channel Angular processing or pressing, in general allows to modify the properties of materials at the microstructure level. In the proposed investigation, the composite specimens in aluminium alloy were subjected to different ECAP passes. The characterization after ECAP was performed by means of warm compression tests between 200 and 300°C with different ram velocities. By a coupled experiment-analytical methodology the friction effect was quantified and the stress-strain curves reported for different temperatures, deformation velocities and ECAP conditions. The friction effect was isolated and the flow behaviour trend of the alloy under different conditions modeled with two models. In particular a model in which the friction variable was considered and the other one in which the friction variable was completely neglected were built and tested. The countertrends in the initial ECAP passes were analyzed by microstructure investigation. The behaviour of the alloy under the considered conditions can be effectively modeled once identified the correct parameters in terms of pre-deformation.openCarlo Bruni; Daniele CiccarelliBruni, Carlo; Ciccarelli, Daniel

Additive Manufacturing using UV Polymerization of Complex Surfaces Generated by Two Main B-Splines

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characterization of double aluminium alloy specimens after ecap

Abstract The Equal Channel Angular Processing or pressing, i.e. the ECAP, allows to modify the properties of materials at the microstructure level. It consists in the induction of a high amount of shear deformation in the material that leads in general to a grain size refinement, a precipitate dispersion and a redistribution of dislocations depending on experiment conditions. The objective of the present investigation is to understand how the ECAP can influence the surface and the bulk mechanical properties of double aluminium alloy specimens. Each specimen was composed of a tubular part of the series AA6026 as well as of a cylindrical part of the series AA6012 assembled together before ECAP. A negligible bonding effect was observed after ECAP and after uniaxial compression tests performed at constant temperatures varying between 200 and 300°C with different press ram velocities. The characterization of each ECAP condition was initially represented in terms of the stress versus deformation flow curves. The load versus stroke curves were preferred due to the friction acting at the forming tool- specimen interface. It was obtained a decrease in the load versus stroke levels with increasing the number of ECAP passes under the experiment conditions of the present investigation. The increase in the press ram velocity determined an increase in the load for a given stroke

Surface disinfections: present and future

The propagation of antibiotic resistance increases the chances of major infections for patients during hospitalization and the spread of health related diseases. Therefore finding new and effective solutions to prevent the proliferation of pathogenic microorganisms is critical, in order to protect hospital environment, such as the surfaces of biomedical devices. Modern nanotechnology has proven to be an effective countermeasure to tackle the threat of infections. On this note, recent scientific breakthroughs have demonstrated that antimicrobial nanomaterials are effective in preventing pathogens from developing resistance. Despite the ability to destroy a great deal of bacteria and control the outbreak of infections, nanomaterials present many other advantages. Moreover, it is unlikely for nanomaterials to develop resistance due to their multiple and simultaneous bactericidal mechanisms. In recent years, science has explored more complex antimicrobial coatings and nanomaterials based on graphene have shown great potential in antibacterial treatment. The purpose of this article is to deepen the discussion on the threat of infections related to surface disinfection and to assess the state of the art and potential solutions, with specific focus on disinfection procedures using nanomaterials

The photodynamic effect of 5-(4-hydroxy-1-butinyl)-2,2’-bithienyl on dermatophytes

The thiophene 5-(4-hydroxy-1-butinyl)2,2[prime prime or minute]-bithienyl (BBTOH) strongly inhibited in vitro eight different dermatophytes. Epidermophyton floccosum proved most sensitive to all doses of BBTOH when applied in conjunction with uv-A irradiation. BBTOH also proved quite active against Nannizia cajetani, the only dermatophyte which was also strongly inhibited when treated (50 [mu]g ml[minus sign]1) and kept in the dark. For this reason, N. cajetani was chosen as the test organism for TEM and SEM aimed at determining what treatment-induced ultrastructural and morphological modifications had occurred. TEM revealed that the photoactive mechanism of BBTOH was similar to that of 2,2[prime prime or minute][ratio]5[prime prime or minute],2[double prime or second]-terthienyl ([alpha]-T). SEM, on the other hand, showed that early culture aging resulted from treatment

Characterization of surface and bulk features of SLM parts

An experiment-analytical procedure based on the building of an object in severe atmosphere resistant steel by SLM is proposed. The complex shape was investigated with the sectioning and laboratory observation of the physical object. The study evidenced the need to get a variable layer thickness to follow double curvature complex shapes. In particular the key variable in the process is the melt bath dimension by which the metal powder assumes by solidification the required global geometry. It was observed that the bath detected mainly in terms of the area of section tends to decrease when approaching to the surface of the physical model where the complex geometry needs to be described. Relationships describing the bath area behaviour and correlations between surface roughness and internal bath dimensions were found and proposed in detail. The surface roughness is highly correlated with the bath area in the zones of the section approaching the surface

Quality of Experience Provision in the Future Internet

This work deals with the satisfaction of the quality of experience (QoE) requirements in the perspective of the emerging future Internet framework. The evolution of the Internet is pointing out its limitations, which are likely to hinder its potential. In this respect, this paper introduces an innovative approach to cope with some key limitations of the present communication networks. In particular, the need of efficiently utilizing the available network resources and of guaranteeing the user expectations in terms of QoE requires a full cognitive approach, which is realized by the introduction of a novel architecture design, the so-called future Internet core platform. The future Internet core platform aims at bringing together the applications world with the network world, hence introducing a further cognitive level while enabling a new generation of applications: network-aware applications. This paper is concerned with an important aspect of the intelligent connectivity between applications and network: the service class association, which, if performed with a cognitive approach, can yield some important improvements and advantages in the emerging information era. The key idea presented in this paper is a real-time dynamic control procedure for the selection of the optimal service class. The approach is based on theoretical considerations validated by a proof-of-concept simulation

Nanostructured delivery systems with improved leishmanicidal activity: a critical review

Natascia Bruni,1 Barbara Stella,2 Leonardo Giraudo,1 Carlo Della Pepa,2 Daniela Gastaldi,3 Franco Dosio2 1Candioli Pharmaceutical Institute Srl, Beinasco, Italy; 2Department of Drug Science and Technology, University of Turin, Turin, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy Abstract: Leishmaniasis is a vector-borne zoonotic disease caused by protozoan parasites of the genus Leishmania, which are responsible for numerous clinical manifestations, such as cutaneous, visceral, and mucocutaneous leishmaniasis, depending on the site of infection for particular species. These complexities threaten 350 million people in 98 countries worldwide. Amastigotes living within macrophage phagolysosomes are the principal target of antileishmanial treatment, but these are not an easy target as drugs must overcome major structural barriers. Furthermore, limitations on current therapy are related to efficacy, toxicity, and cost, as well as the length of treatment, which can increase parasitic resistance. Nanotechnology has emerged as an attractive alternative as conventional drugs delivered by nanosized carriers have improved bioavailability and reduced toxicity, together with other characteristics that help to relieve the burden of this disease. The significance of using colloidal carriers loaded with active agents derives from the physiological uptake route of intravenous administered nanosystems (the phagocyte system). Nanosystems are thus able to promote a high drug concentration in intracellular mononuclear phagocyte system (MPS)-infected cells. Moreover, the versatility of nanometric drug delivery systems for the deliberate transport of a range of molecules plays a pivotal role in the design of therapeutic strategies against leishmaniasis. This review discusses studies on nanocarriers that have greatly contributed to improving the efficacy of antileishmaniasis drugs, presenting a critical review and some suggestions for improving drug delivery. Keywords: amphotericin B, drug delivery systems, drug targeting, human leishmaniasis, polymeric nanoparticl