487 research outputs found
Hadamard states from null infinity
Free field theories on a four dimensional, globally hyperbolic spacetime,
whose dynamics is ruled by a Green hyperbolic partial differential operator,
can be quantized following the algebraic approach. It consists of a two-step
procedure: In the first part one identifies the observables of the underlying
physical system collecting them in a *-algebra which encodes their relational
and structural properties. In the second step one must identify a quantum
state, that is a positive, normalized linear functional on the *-algebra out of
which one recovers the interpretation proper of quantum mechanical theories via
the so-called Gelfand-Naimark-Segal theorem. In between the plethora of
possible states, only few of them are considered physically acceptable and they
are all characterized by the so-called Hadamard condition, a constraint on the
singular structure of the associated two-point function. Goal of this paper is
to outline a construction scheme for these states which can be applied whenever
the underlying background possesses a null (conformal) boundary. We discuss in
particular the examples of a real, massless conformally coupled scalar field
and of linearized gravity on a globally hyperbolic and asymptotically flat
spacetime.Comment: 23 pages, submitted to the Proceedings of the conference "Quantum
Mathematical Physics", held in Regensburg from the 29th of September to the
02nd of October 201
Magnetic-field-induced singularities in spin dependent tunneling through InAs quantum dots
Current steps attributed to resonant tunneling through individual InAs
quantum dots embedded in a GaAs-AlAs-GaAs tunneling device are investigated
experimentally in magnetic fields up to 28 T. The steps evolve into strongly
enhanced current peaks in high fields. This can be understood as a
field-induced Fermi-edge singularity due to the Coulomb interaction between the
tunneling electron on the quantum dot and the partly spin polarized Fermi sea
in the Landau quantized three-dimensional emitter.Comment: 5 pages, 4 figure
No evidence for an association between the -36A>C phospholamban gene polymorphism and a worse prognosis in heart failure
Background: In Brazil, heart failure leads to approximately 25,000 deaths per year. Abnormal calcium handling is a hallmark of heart failure and changes in genes encoding for proteins involved in the re-uptake of calcium might harbor mutations leading to inherited cardiomyopathies. Phospholamban (PLN) plays a prime role in cardiac contractility and relaxation and mutations in the gene encoding PLN have been associated with dilated cardiomyopathy. In this study, our objective was to determine the presence of the -36A>C alteration in PLN gene in a Brazilian population of individuals with HF and to test whether this alteration is associated with heart failure or with a worse prognosis of patients with HF. Methods: We genotyped a cohort of 881 patients with HF and 1259 individuals from a cohort of individuals from the general population for the alteration -36A>C in the PLN gene. Allele and genotype frequencies were compared between groups (patients and control). In addition, frequencies or mean values of different phenotypes associated with cardiovascular disease were compared between genotypic groups. Finally, patients were prospectively followed-up for death incidence and genotypes for the -36A>C were compared regarding mortality incidence in HF patients. Results: No significant association was found between the study polymorphism and HF in our population. In addition, no association between PLN -36A>C polymorphism and demographic, clinical and functional characteristics and mortality incidence in this sample of HF patients was observed. Conclusion: Our data do not support a role for the PLN -36A>C alteration in modulating the heart failure phenotype, including its clinical course, in humans
Coupled quantum dots as quantum gates
We consider a new quantum gate mechanism based on electron spins in coupled
semiconductor quantum dots. Such gates provide a general source of spin
entanglement and can be used for quantum computers. We determine the exchange
coupling J in the effective Heisenberg model as a function of magnetic (B) and
electric fields, and of the inter-dot distance (a) within the Heitler-London
approximation of molecular physics. This result is refined by using
sp-hybridization, and by the Hund-Mulliken molecular-orbit approach which leads
to an extended Hubbard description for the two-dot system that shows a
remarkable dependence on B and a due to the long-range Coulomb interaction. We
find that the exchange J changes sign at a finite field (leading to a
pronounced jump in the magnetization) and then decays exponentially. The
magnetization and the spin susceptibilities of the coupled dots are calculated.
We show that the dephasing due to nuclear spins in GaAs can be strongly
suppressed by dynamical nuclear spin polarization and/or by magnetic fields.Comment: 10 pages, 4 figures. v2: minor corrections, appendix added. to be
published in Phys.Rev.
Donor states in modulation-doped Si/SiGe heterostructures
We present a unified approach for calculating the properties of shallow
donors inside or outside heterostructure quantum wells. The method allows us to
obtain not only the binding energies of all localized states of any symmetry,
but also the energy width of the resonant states which may appear when a
localized state becomes degenerate with the continuous quantum well subbands.
The approach is non-variational, and we are therefore also able to evaluate the
wave functions. This is used to calculate the optical absorption spectrum,
which is strongly non-isotropic due to the selection rules. The results
obtained from calculations for Si/SiGe quantum wells allow us to
present the general behavior of the impurity states, as the donor position is
varied from the center of the well to deep inside the barrier. The influence on
the donor ground state from both the central-cell effect and the strain arising
from the lattice mismatch is carefully considered.Comment: 17 pages, 10 figure
Designing programs for eliminating canine rabies from islands: Bali, Indonesia as a case study
<p>Background:
Canine rabies is one of the most important and feared zoonotic diseases in the world. In some regions rabies elimination is being successfully coordinated, whereas in others rabies is endemic and continues to spread to uninfected areas. As epidemics emerge, both accepted and contentious control methods are used, as questions remain over the most effective strategy to eliminate rabies. The Indonesian island of Bali was rabies-free until 2008 when an epidemic in domestic dogs began, resulting in the deaths of over 100 people. Here we analyze data from the epidemic and compare the effectiveness of control methods at eliminating rabies.</p>
<p>Methodology/Principal Findings:
Using data from Bali, we estimated the basic reproductive number, R0, of rabies in dogs, to be ~1·2, almost identical to that obtained in ten–fold less dense dog populations and suggesting rabies will not be effectively controlled by reducing dog density. We then developed a model to compare options for mass dog vaccination. Comprehensive high coverage was the single most important factor for achieving elimination, with omission of even small areas (<0.5% of the dog population) jeopardizing success. Parameterizing the model with data from the 2010 and 2011 vaccination campaigns, we show that a comprehensive high coverage campaign in 2012 would likely result in elimination, saving ~550 human lives and ~$15 million in prophylaxis costs over the next ten years.</p>
<p>Conclusions/Significance:
The elimination of rabies from Bali will not be achieved through achievable reductions in dog density. To ensure elimination, concerted high coverage, repeated, mass dog vaccination campaigns are necessary and the cooperation of all regions of the island is critical. Momentum is building towards development of a strategy for the global elimination of canine rabies, and this study offers valuable new insights about the dynamics and control of this disease, with immediate practical relevance.</p>
Electron transport through double quantum dots
Electron transport experiments on two lateral quantum dots coupled in series
are reviewed. An introduction to the charge stability diagram is given in terms
of the electrochemical potentials of both dots. Resonant tunneling experiments
show that the double dot geometry allows for an accurate determination of the
intrinsic lifetime of discrete energy states in quantum dots. The evolution of
discrete energy levels in magnetic field is studied. The resolution allows to
resolve avoided crossings in the spectrum of a quantum dot. With microwave
spectroscopy it is possible to probe the transition from ionic bonding (for
weak inter-dot tunnel coupling) to covalent bonding (for strong inter-dot
tunnel coupling) in a double dot artificial molecule. This review on the
present experimental status of double quantum dot studies is motivated by their
relevance for realizing solid state quantum bits.Comment: 32 pages, 31 figure
Negatively Charged Excitons and Photoluminescence in Asymmetric Quantum Well
We study photoluminescence (PL) of charged excitons () in narrow
asymmetric quantum wells in high magnetic fields B. The binding of all
states strongly depends on the separation of electron and hole layers.
The most sensitive is the ``bright'' singlet, whose binding energy decreases
quickly with increasing even at relatively small B. As a result, the
value of B at which the singlet--triplet crossing occurs in the spectrum
also depends on and decreases from 35 T in a symmetric 10 nm GaAs well
to 16 T for nm. Since the critical values of at which
different states unbind are surprisingly small compared to the well
width, the observation of strongly bound states in an experimental PL
spectrum implies virtually no layer displacement in the sample. This casts
doubt on the interpretation of PL spectra of heterojunctions in terms of
recombination
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies
Blood phosphorylated tau (p-tau) biomarkers, at differing sites, demonstrate high accuracy to detect Alzheimerʼs disease (AD). However, knowledge on the optimal marker for disease identification across the AD continuum and the link to pathology is limited. This is partly due to heterogeneity in analytical methods. In this study, we employed an immunoprecipitation mass spectrometry method to simultaneously quantify six phosphorylated (p-tau181, p-tau199, p-tau202, p-tau205, p-tau217 and p-tau231) and two non-phosphorylated plasma tau peptides in a total of 214 participants from the Paris Lariboisière and Translational Biomarkers of Aging and Dementia cohorts. Our results indicate that p-tau217, p-tau231 and p-tau205 are the plasma tau forms that best reflect AD-related brain changes, although with distinct emergences along the disease course and correlations with AD features—amyloid and tau. These findings support the differential association of blood p-tau variants with AD pathology, and our method offers a potential tool for disease staging in clinical trials
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