On the starting process of strongly nonlinear vortex/Rayleigh-wave interactions

An oncoming two-dimensional laminar boundary layer that develops an unstable inflection point and becomes three-dimensional is described by the Hall-Smith (1991) vortex/wave interaction equations. These equations are now examined in the neighbourhood of the position where the critical surface starts to form. A consistent structure is established in which an inviscid core flow is matched to a viscous buffer-layer solution where the appropriate jump condition on the transverse shear stress is satisfied. The final result is a bifurcation equation for the (constant) amplitude of the wave pressure. A representative classical velocity profile is considered to illustrate solutions of this equation for a range of values of the wave-numbers

On vortex/wave interactions. Part 1. Non-symmetrical input and cross-flow in boundary layers

The paper studies certain effects of non-symmetry on vortex/wave interactions, for inviscid inflexional waves interacting nonlinearly with the vortex component of the mean flow in boundary-layer transition at large Reynolds number. Two types of non-symmetry are investigated, namely for unequal input wave amplitudes and for small cross-flows. These lead to coupled integro-differential equations for spatial development of the wave amplitudes, which are examined in an essentially equivalent differential form for various degrees of the non-symmetry present. Each type of non-symmetry can have a significant influence on the nonlinear interaction properties. Special emphasis is given to bounded solutions, and numerous interesting new flow responses are found analytically and computationally. The theory provides a basis for tackling enhanced non-symmetry in the input or stronger cross-flows

On vortex/wave interactions. Part 2. Originating from axisymmetric flow with swirl

Following the study in Part 1 of cross-flow and other non-symmetric effects on vortex/wave interactions in boundary layers, the present Part 2 applies the ideas of Part 1 and related works to an incident axisymmetric flow supplemented by a small swirl or azimuthal velocity. This is with a view to possibly increasing understanding of vortex breakdown. The wave components involved are predominantly inviscid Rayleigh-like ones. The presence of the swirl leads to extra features and complications associated mainly with extra logarithmic contributions but for the dominant interactions essentially the same equations as in Part 1 are found. These dominant nonlinear interactions must be based on azimuthal wavenumbers of +/-1 in the case of the Squire jet with swirl. In contrast to Part 1, which consisted mainly of an analysis of the quasi-bounded solutions, a representative set of numerical solutions of the full integro-differential amplitude equations is presented, for realistic axial and swirl velocity profiles. The work points also to the influence of further increases in the incident swirl

Extracting the Groupwise Core Structural Connectivity Network: Bridging Statistical and Graph-Theoretical Approaches

Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuro-science. Recent evidence suggests there's a tightly connected network shared between humans. Obtaining this network will, among many advantages , allow us to focus cognitive and clinical analyses on common connections, thus increasing their statistical power. In turn, knowledge about the common network will facilitate novel analyses to understand the structure-function relationship in the brain. In this work, we present a new algorithm for computing the core structural connectivity network of a subject sample combining graph theory and statistics. Our algorithm works in accordance with novel evidence on brain topology. We analyze the problem theoretically and prove its complexity. Using 309 subjects, we show its advantages when used as a feature selection for connectivity analysis on populations, outperforming the current approaches

Automatic, fast and robust characterization of noise distributions for diffusion MRI

Knowledge of the noise distribution in magnitude diffusion MRI images is the centerpiece to quantify uncertainties arising from the acquisition process. The use of parallel imaging methods, the number of receiver coils and imaging filters applied by the scanner, amongst other factors, dictate the resulting signal distribution. Accurate estimation beyond textbook Rician or noncentral chi distributions often requires information about the acquisition process (e.g. coils sensitivity maps or reconstruction coefficients), which is not usually available. We introduce a new method where a change of variable naturally gives rise to a particular form of the gamma distribution for background signals. The first moments and maximum likelihood estimators of this gamma distribution explicitly depend on the number of coils, making it possible to estimate all unknown parameters using only the magnitude data. A rejection step is used to make the method automatic and robust to artifacts. Experiments on synthetic datasets show that the proposed method can reliably estimate both the degrees of freedom and the standard deviation. The worst case errors range from below 2% (spatially uniform noise) to approximately 10% (spatially variable noise). Repeated acquisitions of in vivo datasets show that the estimated parameters are stable and have lower variances than compared methods.Comment: v2: added publisher DOI statement, fixed text typo in appendix A

CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis

© 2016, Company of Biologists Ltd. All rights reserved. Intracellular chloride channel protein 1 (CLIC1) participates in inflammatory processes by regulating macrophage phagosomal functions such as pH and proteolysis. Here, we sought to determine if CLIC1 can regulate adaptive immunity by actions on dendritic cells (DCs), the key professional antigen presenting cells. To do this, we first generated bone marrow-derived DCs (BMDCs) from germline CLIC1 gene-deleted (CLIC1-/-) and wild-type (CLIC1+/+) mice, then studied them in vitro and in vivo. We found phagocytosis triggered cytoplasmic CLIC1 translocation to the phagosomal membrane where it regulated phagosomal pH and proteolysis. Phagosomes from CLIC1-/- BMDCs displayed impaired acidification and proteolysis, which could be reproduced if CLIC1+/+, but not CLIC1-/- cells, were treated with IAA94, a CLIC family ion channel blocker. CLIC1-/- BMDC displayed reduced in vitro antigen processing and presentation of full-length myelin oligodendrocyte glycoprotein (MOG) and reduced MOG-induced experimental autoimmune encephalomyelitis. These data suggest that CLIC1 regulates DC phagosomal pH to ensure optimal processing of antigen for presentation to antigen-specific T-cells. Further, they indicate that CLIC1 is a novel therapeutic target to help reduce the adaptive immune response in autoimmune diseases

Nonlinear evolution of Rayleigh waves in an initial value context: Non-symmetric input and cross-flow

In recent papers the present authors considered the effects of small cross-flow on the evolution of two unequal oblique waves. In these studies the relative size of the crossflow meant that a diffusion (or buffer) layer was required around the critical layer to smooth out the algebraic growth in the mean-flow distortion generated by the nonlinear critical-layer interactions. The present analysis increases the cross-flow to an order of magnitude such that the buffer and critical layers coalesce. In this instance the nonlinear critical layer contains viscous as well as nonequilibrium effects. The resulting amplitude equations are solved for perturbations initiated at a fixed station in the flow

Holographic Reconstruction and Renormalization in Asymptotically Ricci-flat Spacetimes

In this work we elaborate on an extension of the AdS/CFT framework to a subclass of gravitational theories with vanishing cosmological constant. By building on earlier ideas, we construct a correspondence between Ricci-flat spacetimes admitting asymptotically hyperbolic hypersurfaces and a family of conformal field theories on a codimension two manifold at null infinity. By truncating the gravity theory to the pure gravitational sector, we find the most general spacetime asymptotics, renormalize the gravitational action, reproduce the holographic stress tensors and Ward identities of the family of CFTs and show how the asymptotics is mapped to and reconstructed from conformal field theory data. In even dimensions, the holographic Weyl anomalies identify the bulk time coordinate with the spectrum of central charges with characteristic length the bulk Planck length. Consistency with locality in the bulk time direction requires a notion of locality in this spectrum.Comment: 44 pages, 4 figures. v2: minor changes in section

The zygomatic implant perforated (ZIP) flap: a new technique for combined surgical reconstruction and rapid fixed dental rehabilitation following low-level maxillectomy.

Abstract This aim of this report is to describe the development and evolution of a new surgical technique for the immediate surgical reconstruction and rapid post-operative prosthodontic rehabilitation with a fixed dental prosthesis following low-level maxillectomy for malignant disease. The technique involves the use of a zygomatic oncology implant perforated micro-vascular soft tissue flap (ZIP flap) for the primary management of maxillary malignancy with surgical closure of the resultant maxillary defect and the installation of osseointegrated support for a zygomatic implant-supported maxillary fixed dental prosthesis. The use of this technique facilitates extremely rapid oral and dental rehabilitation within a few weeks of resective surgery, providing rapid return to function and restoring appearance following low-level maxillary resection, even in cases where radiotherapy is required as an adjuvant treatment post-operatively. The ZIP flap technique has been adopted as a standard procedure in the unit for the management of low-level maxillary malignancy, and this report provides a detailed step-by-step approach to treatment and discusses modifications developed over the treatment of an initial cohort of patients