Some remarks on the social and professionals status of physicians and surgeons in the iberian world, 16th-18th centuries

These cursory remarks, which do not pretend to do more thanbriefly discuss some aspects of this topic, will deal mainly with Portugaland her overseas possessions, since I assume that this angle willbe less familiar to you than the Spanish and Spanish-American

Occupational and non-occupational physical activity and the social determinants of physical activity : results from the Health Survey for England

Background: This article aims to examine the relative contribution of occupational activity to English adults&rsquo; meeting of government recommendations for physical activity (PA). Methods: Data were extracted from a cross-sectional survey of householders in the UK via the Health Survey for England.1 In total, 14,018 adult participants were included in the analysis. Multivariate logistic regression was used to examine the odds of achieving PA recommendations with and without including occupational activity and to examine the contribution of gender and social and demographic characteristics. Results: When occupational PA was included, 36% of men and 25% of women were active at the recommended level. Once occupational PA was removed, these proportions were 23% and 19%, respectively. These results were socially patterned, most notably by age and gender.Conclusions: Occupational PA provides a substantial contribution to those meeting the government target for PA. <br /

Fidalgos portugueses e bailadeiras indianas (Séculos XVII e XVIII)

  "A raça portuguesa", escrevia o preclaro investigador que foi Sousa Viterbo, "é tida e havida como uma das que mais fa-cilmente se acclimam, das que mais facilmente fraternizam com as raças indígenas, qualquer que seja a sua procedéncia . Na Africa, na Asia, na América, na Oceania, o cruzamento ef-fectua-se sem obstáculo. Affonso d'Albuquerque, querendo fir-mar pé no Oriente, repartiu pelos seus soldados as captivas de Goa, e foi um dia de júbilo, um dia de festa pagã, aquelle em que se effectuou o consórcio. Esta facilidade, se é por um lado um incentivo para a colonização, é por outro lado de certo um grave defeito, porque tende a neutralizar, a apagar, as qua-lidades superiores de raça dominante. Nisto se distinguem e muito os ingleses, que em toda a parte se extremam, conser-vando-se a distáncia das raças nativas. As alianças sam pouco vulgares, e dominadores e dominados guardam entre si as mes-mas reservas, que as differentes castas na India"

Some remarks on the social and professionals status of physicians and surgeons in the iberian world, 16th-18th centuries

These cursory remarks, which do not pretend to do more than briefly discuss some aspects of this topic, will deal mainly with Portugal and her overseas possessions, since I assume that this angle will be less familiar to you than the Spanish and Spanish-American

Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia

Cyclic neutropenia is a rare hematologic disease that is characterized by regular oscillations in blood neutrophil counts from normal levels (absolute neutrophil count [ANC], \u3e1.5×109 per liter) to severe neutropenia (ANC, \u3c0.2×109 per liter), usually with a cycle length of about 21 days.When patients with this disorder have neutropenia, they often have fever and mouth ulcers and are at risk for severe infections. Cyclic neutropenia is usually an autosomal dominant disorder caused by mutations in the gene encoding neutrophil elastase (ELANE)

Supplemental Income: British newspaper colour supplements in the 1960s

The introduction of colour supplements by three ‘quality’ newspapers during the 1960s was a key development in the British press during the decade, and was described by the editor of the Sunday Times as ‘perhaps the most successful single innovation in post-war journalism’. This article provides an overview of the advent of the colour supplements, explaining why they emerged when they did and developed in the manner they did, and exploring some of the difficulties and issues that attended their arrival. The article also demonstrates that sections of the British press were capable of taking advantage of changes in print and advertising culture brought about by the arrival of the post-war consumer society. However, the term ‘colour supplement’ became pejorative shorthand for the perceived vacuity of this new society, in part because of the tension that existed between the editorial and advertising content of these modish new publications. Consequently, the success of the colour supplement experiment was not universally celebrated

A Multiancestral Genome-Wide Exome Array Study of Alzheimer Disease, Frontotemporal Dementia, and Progressive Supranuclear Palsy

Importance Previous studies have indicated a heritable component of the etiology of neurodegenerative diseases such as Alzheimer disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP). However, few have examined the contribution of low-frequency coding variants on a genome-wide level. Objective To identify low-frequency coding variants that affect susceptibility to AD, FTD, and PSP. Design, Setting, and Participants We used the Illumina HumanExome BeadChip array to genotype a large number of variants (most of which are low-frequency coding variants) in a cohort of patients with neurodegenerative disease (224 with AD, 168 with FTD, and 48 with PSP) and in 224 control individuals without dementia enrolled between 2005-2012 from multiple centers participating in the Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease (GIFT) Study. An additional multiancestral replication cohort of 240 patients with AD and 240 controls without dementia was used to validate suggestive findings. Variant-level association testing and gene-based testing were performed. Main Outcomes and Measures Statistical association of genetic variants with clinical diagnosis of AD, FTD, and PSP. Results Genetic variants typed by the exome array explained 44%, 53%, and 57% of the total phenotypic variance of AD, FTD, and PSP, respectively. An association with the known AD gene ABCA7 was replicated in several ancestries (discovery P = .0049, European P = .041, African American P = .043, and Asian P = .027), suggesting that exonic variants within this gene modify AD susceptibility. In addition, 2 suggestive candidate genes, DYSF (P = 5.53 × 10−5) and PAXIP1 (P = 2.26 × 10−4), were highlighted in patients with AD and differentially expressed in AD brain. Corroborating evidence from other exome array studies and gene expression data points toward potential involvement of these genes in the pathogenesis of AD. Conclusions and Relevance Low-frequency coding variants with intermediate effect size may account for a significant fraction of the genetic susceptibility to AD and FTD. Furthermore, we found evidence that coding variants in the known susceptibility gene ABCA7, as well as candidate genes DYSF and PAXIP1, confer risk for AD