Adapting Conventional Tools to Analyse Ducted and Open Centre Tidal Stream Turbines

This is the author accepted manuscript. The final version is available from EWTEC via the link in this record.This paper details a hydrodynamic model based on Blade Element Momentum Theory (BEMT) developed to assess ’conventional’ 3-bladed tidal stream turbines (TSTs), adapted here to analyse an ’unconventional’ case of a ducted and open centre device. Validations against a more detailed coupled Reynolds averaged computational fluid dynamics (RANS-BEM) model shows excellent agreement, of within 2% up to the peak power condition, with associated computational times in the order of a few minutes on a single core. The paper demonstrates the application of hydrodynamic forces into a structural analysis tool, in order to assess blade stress distributions of a generic hubless turbine. Incorporation of parameters such as non-uniform inflows and blade weight forces are investigated, with their effects on stress profiles presented. Key findings include: i) the adapted BEMT model replicates the majority of turbine performance characteristics estimated through previous CFD assessments; ii) the proposed model reduces the computational effort by several orders of magnitude compared to the reference coupled CFD, making it suitable for engineering assessments iii) blade stress distribution profiles are quantified, detailing concentration zones and cyclic values for use in fatigue analyses. This work forms part of a greater project aimed to develop a suite of analytical tools to perform engineering assessments of bi-directional ducted TSTsThis research is carried out as part of the Industrial Doctoral centre for Offshore Renewable Energy (IDCORE), funded by the Energy Technology partnership and the RCUK Energy programme (Grant number EP/J500847/1), in collaboration with EDF R&D

Glycosylation as new pharmacological strategies for diseases associated with excessive angiogenesis

Angiogenesis is a complex process describing the growth of new blood vessels from existing vasculature, and is triggered by local pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which increase the metabolism of endothelial cells (ECs). Angiogenesis takes part in various physiological conditions such as embryogenesis, placental growth, and in pathological conditions such as tumor growth, diabetic retinopathy, rheumatoid arthritis (RA) and ischemic diseases. Current therapies against excessive angiogenesis target vascular growth signaling. However, tumors often counteract these therapies through adaptive mechanisms, thus novel alternative anti-angiogenic strategies are needed. Targeting metabolism is a new anti-angiogenic paradigm, especially through the inhibition of energy metabolism and glycosylation, with the perspective of maintaining the delicate balance between the beneficial and deleterious effects of excessive angiogenesis in patients. Recent studies described a role for EC glycolysis and its main regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in the regulation of angiogenesis, but only few studies are related to the role of the hexosamine biosynthesis pathway during angiogenesis. Glycosylation allows the formation of glycoproteins, glycolipids and proteoglycans and impacts many pathways. The addition of glycans to N-linked proteins is catalyzed by the enzymatic activity of N-acetylglucosaminyltransferases (GnTs), which regulates the glycosylation status of key angiogenic factors such as VEGF receptor 2 (VEGFR2) and Notch. In addition, glycan-galectin (Gal) interactions regulate vascular signaling programs and may contribute to tumor adaptations to anti-angiogenic strategies. Herein, we review novel pharmacological strategies targeting glycosylation, which could be used to decrease excessive angiogenesis in pathological conditions

CO-FREE Alternative Test Products for Copper Reduction in Agriculture

The project CO-FREE (2012-2016) aimed to develop strategies to replace/reduce copper use in organic, integrated and conventional farming. CO-FREE alternative test products (CTPs) were tested and integrated together with decision support systems, disease-tolerant varieties, and innovative breeding goals (ideotypes) into improved management strategies. CO-FREE focused on apple/apple scab (Venturia inaequalis), grape/downy mildew (Plasmopara viticola), and tomato and potato/late blight (Phytophthora infestans). Starting point of the project were ten CTPs with direct or indirect modes of action including Trichoderma atroviride SC1 and protein extract SCNB, Lysobacter spp., yeast-based derivatives, Cladosporium cladosporioides H39, the oligosaccharidic complex COS-OGA, Aneurinibacillus migulanus and Xenorhabdus bovienii, sage (Salvia officinalis) extract, liquorice (Glycyrrhiza glabra) extract, PLEX- and seaweed plant extracts. As the project progressed, further promising CTPs were included by the partners. Field trials were performed in different European countries in 2012-2015 following EPPO standards. In the first years, stand-alone applications of CTPs were tested. In the following years these were integrated into complete strategies. Effects on main and further diseases, on yield and on non-target organisms were assessed. Here, field trial results with CTPs are summarized

Intrinsic Textures for Relightable Free-Viewpoint Video

This paper presents an approach to estimate the intrinsic texture properties (albedo, shading, normal) of scenes from multiple view acquisition under unknown illumination conditions. We introduce the concept of intrinsic textures, which are pixel-resolution surface textures representing the intrinsic appearance parameters of a scene. Unlike previous video relighting methods, the approach does not assume regions of uniform albedo, which makes it applicable to richly textured scenes. We show that intrinsic image methods can be used to refine an initial, low-frequency shading estimate based on a global lighting reconstruction from an original texture and coarse scene geometry in order to resolve the inherent global ambiguity in shading. The method is applied to relighting of free-viewpoint rendering from multiple view video capture. This demonstrates relighting with reproduction of fine surface detail. Quantitative evaluation on synthetic models with textured appearance shows accurate estimation of intrinsic surface reflectance properties. © 2014 Springer International Publishing

Electron donors and cyanoimidazole acceptors: Cyclic voltammetry and molecular orbital study

Voltammetric measurements on a series of cyanoimidazoles and their metal complexes are reported and compared with those for various donors and acceptors measured under the same conditions. LUMO energies from extended Huckel calculations correlate well with reduction potentials of cyanoimidazoles. Extended Huckel calculations also give insights into the interaction of the metal complexes of tetracyanobiimidazole and the nature of molecular stacking.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27187/1/0000190.pd

Perceptual quality of BRDF approximations: dataset and metrics

International audienceBidirectional Reflectance Distribution Functions (BRDFs) are pivotal to the perceived realism in image synthesis. While measured BRDF datasets are available, reflectance functions are most of the time approximated by analytical formulas for storage efficiency reasons. These approximations are often obtained by minimizing metrics such as L 2 —or weighted quadratic—distances, but these metrics do not usually correlate well with perceptual quality when the BRDF is used in a rendering context, which motivates a perceptual study. The contributions of this paper are threefold. First, we perform a large-scale user study to assess the perceptual quality of 2026 BRDF approximations, resulting in 84138 judgments across 1005 unique participants. We explore this dataset and analyze perceptual scores based on material type and illumination. Second, we assess nine analytical BRDF models in their ability to approximate tabulated BRDFs. Third, we assess several image-based and BRDF-based (Lp, optimal transport and kernel distance) metrics in their ability to approximate perceptual similarity judgments

Epifluorescence et flore bactérienne des eaux à usage thérapeutique

Le dénombrement de la flore bactérienne est l'un des paramètres réglementaires déterminé lors de l'analyse microbiologique des eaux. Les méthodes traditionnelles utilisées pour l'évaluer présentent des inconvénients, aussi, de nombreuses méthodes alternatives simples et rapides se sont développées comme la microscopie par épifluorescence. Dans ce travail, le dénombrement par épifluorescence de la flore métaboliquement active (fluorochrome : fluorescéine) est étudié sur diverses eaux à usage thérapeutique (émergences d'eaux minérales naturelles, eau pour hémodialyse) et comparé aux méthodes traditionnelles de dénombrement de la flore bactérienne