Analytical ray-tracing in planetary atmospheres

Ground-based astro-geodetic observations and atmospheric occultations, are two examples of observational techniques requiring a scrutiny analysis of atmospheric refraction. In both cases, the measured changes in observables are geometrically related to changes in the photon path and the light time of the received electromagnetic signal. In the context of geometrical optics, the change in the physical properties of the signal are related to the refractive profile of the crossed medium. Therefore, having a clear knowledge of how the refractivity governs the photon path and the light time evolution is of prime importance to clearly understand observational features. Analytical studies usually focused on spherically symmetric atmospheres and only few aimed at exploring the effect of the non-spherical symmetry on the observables. In this paper, we analytically perform the integration of the photon path and the light time of rays traveling across a planetary atmosphere. We do not restrict our attention to spherically symmetric atmospheres and introduce a comprehensive mathematical framework which allows to handle any kind of analytical studies in the context of geometrical optics. To highlight the capabilities of this new formalism, we carry out five realistic applications for which we derive analytical solutions. The accuracy of the method of integration is assessed by comparing our results to a numerical integration of the equations of geometrical optics in the presence of a quadrupolar moment $J_2$. This shows that the analytical solution leads to the determination of the light time and the refractive bending with relative errors at the level of one part in $10^8$ and one part in $10^5$, for typical values of the refractivity and the $J_2$ parameter at levels of $10^{-4}$ and $10^{-2}$, respectively

Analytical study of the radio signals propagation in planetary atmospheres

The ESA JUICE (JUpiter ICy moons Explorer) mission is planned for launch in 2022 and arrival at Jupiter around 2030. The mission is dedicated to the study of the giant gaseous and its largest moons. While the spacecraft will probe the Jovian system it will be occulted by the atmosphere of Jupiter or its satellites as seen from antennas on Earth. Such a configuration offers a great opportunity to study remotely the physical properties of the occulting atmosphere using radio links as the probe is being occulted. Indeed, non-unity index of refraction causes the electromagnetic waves to depart from the straight line and also impacts the propagation speed of the waves. Both changes modify the wave frequency and conversely, from the time variation of the Doppler measurements the index of refraction profile can be retrieved. In the literature, there are different approaches devoted to the retrieval of the refractive profile from these observables. Let mention, i) the analytic formulation of the Abel inversion which is employed for spherically symmetric atmospheres, and ii) the ray tracing method which is a numerical integration of the fundamental equations of optics and which is well suited for atmospheres with more complicated shapes. Both possess their own advantages and inconveniences. For instance, to invert a complete set of data, the ray tracing method requires more computational time than the Abel transformation. In return, the Abel inversion is based on the spherical symmetry assumption while the ray tracing technique can handle non-radial gradient in the refractive profile. In the context of the future occultations of JUICE by Jupiter, we discuss the benefit of a new formalism based on a full reformulation of the fundamental equations of optics. This new approach let to provide a very comprehensive description of the light trajectory inside a planetary atmosphere with no assumption on the refractive profile. In the special case where the departure from the spherical symmetry is small, we present an analytic solution which is well suited for the data processing of radio occultation experiments. Indeed, this solution can handle the effect of a non-spherically symmetric atmosphere with a low computational cost. We use this solution to process the Cassini Doppler data acquired during an occultation by the oblate atmosphere of Saturn. The validity of the proposed approach is assessed comparing the results with other studies available in the literature

Development of a Large-Eddy-Simulation approach for free surface complex flows

Water Qualit

Development of a Large-Eddy-Simulation approach with Telemac-3D

Water Qualit

Testing Lorentz symmetry with planetary orbital dynamics

Planetary ephemerides are a very powerful tool to constrain deviations from the theory of General Relativity using orbital dynamics. The effective field theory framework called the Standard-Model Extension (SME) has been developed in order to systematically parametrize hypothetical violations of Lorentz symmetry (in the Standard Model and in the gravitational sector). In this communication, we use the latest determinations of the supplementary advances of the perihelia and of the nodes obtained by planetary ephemerides analysis to constrain SME coefficients from the pure gravity sector and also from gravity-matter couplings. Our results do not show any deviation from GR and they improve current constraints. Moreover, combinations with existing constraints from Lunar Laser Ranging and from atom interferometry gravimetry allow us to disentangle contributions from the pure gravity sector from the gravity-matter couplings.Comment: 12 pages, 2 figures, version accepted for publication in Phys. Rev.

Overview of the current use of levosimendan in France: a prospective observational cohort study

Abstract Background Following the results of randomized controlled trials on levosimendan, French health authorities requested an update of the current use and side-effects of this medication on a national scale. Method The France-LEVO registry was a prospective observational cohort study reflecting the indications, dosing regimens, and side-effects of levosimendan, as well as patient outcomes over a year. Results The patients included ( n = 602) represented 29.6% of the national yearly use of levosimendan in France. They were treated for cardiogenic shock ( n = 250, 41.5%), decompensated heart failure ( n = 127, 21.1%), cardiac surgery-related low cardiac output prophylaxis and/or treatment ( n = 86, 14.3%), and weaning from veno-arterial extracorporeal membrane oxygenation ( n = 82, 13.6%). They received 0.18 ± 0.07 µg/kg/min levosimendan over 26 ± 8 h. An initial bolus was administered in 45 patients (7.5%), 103 (17.1%) received repeated infusions, and 461 (76.6%) received inotropes and or vasoactive agents concomitantly. Hypotension was reported in 218 patients (36.2%), atrial fibrillation in 85 (14.1%), and serious adverse events in 17 (2.8%). 136 patients (22.6%) died in hospital, and 26 (4.3%) during the 90-day follow-up. Conclusions We observed that levosimendan was used in accordance with recent recommendations by French physicians. Hypotension and atrial fibrillation remained the most frequent side-effects, while serious adverse event potentially attributable to levosimendan were infrequent. The results suggest that this medication was safe and potentially associated with some benefit in the population studied

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Constaints on Lorentz symmetry violations using lunar laser ranging observations

International audienceGeneral Relativity (GR) and the standard model of particle physics provide a comprehensive description of the four interactions of nature. A quantum gravity theory is expected to merge these two pillars of modern physics. From unification theories, such a combination would lead to a breaking of fundamental symmetry appearing in both GR and the standard model of particle physics as the Lorentz symmetry. Lorentz symmetry violations in all fields of physics can be parametrized by an effective field theory framework called the standard-model extension (SME). Local Lorentz Invariance violations in the gravitational sector should impact the orbital motion of bodies inside the solar system, such as the Moon. Thus, the accurate lunar laser ranging (LLR) data can be analyzed in order to study precisely the lunar motion to look for irregularities. For this purpose, ELPN (Ephéméride Lunaire Parisienne Numérique), a new lunar ephemeris has been integrated in the SME framework. This new numerical solution of the lunar motion provides time series dated in temps dynamique barycentrique (TDB). Among that series, we mention the barycentric position and velocity of the Earth-Moon vector, the lunar libration angles, the time scale difference between the terrestrial time and TDB and partial derivatives integrated from variational equations. ELPN predictions have been used to analyzed LLR observations. In the GR framework, the residuals standard deviations has turned out to be the same order of magnitude compare to those of INPOP13b and DE430 ephemerides. In the framework of the minimal SME, LLR data analysis provided constraints on local Lorentz invariance violations. Spetial attention was paid to analyze uncertainties to provide the most realistic constraints. Therefore, in a first place, linear combinations of SME coefficients have been derived and fitted to LLR observations. In a second time, realistic uncertainties have been determined with a resampling method. LLR data analysis did not reveal local Lorentz invariance vio lations arising on the lunar orbit. Therefore, GR predictions are recovered with absolute precisions of the order of 10-9 to 10-12